Background: Chemotherapy and radiation resistance are major causes of failure in cancer treatment. The response to treatment in cancer cells depends on several mechanisms and pathways such as Janus kinases-signal transducers and activators of transcription JAK/STAT pathway. STAT1 was the first described transcription factor in the STAT family. STAT1 is activated by stimulation of signaling proteins such as type II interferon (IFN- ?) and the activated STAT1 translocates from cytoplasm to nucleus.

Syftet med vår studie är att ta reda på hur matematiklärare på grundskolans senare år ser på verklighetsanknuten matematikundervisning samt att undersöka hur de eventuellt bedriver sådan. För att uppnå syftet utformade vi en enkät som delades ut till 60 verksamma matematiklärare i år 7-9 inom Luleå kommun. Under bearbetningen av det insamlade materialet framträdde bilden av att inställningen bland lärarna till största delen är positiv till verklighetsanknuten matematikundervisning. Det framgår också av undersökningen hur sådan matematikundervisning bedrivs, närmare bestämt genom att använda matematiklitteraturen, nyttja exempel ur vardagslivet eller arbeta med tema och arbeta med projektarbeten. Detta styrker oss i vår uppfattning att verklighetsanknuten matematikundervisning är värdefull för att fånga elevernas intresse och få dem att inse nyttan av skolmatematiken.

Many companies today are investing in various computer-based tools to support their planning, decision making or communication processes. However, end users are often reluctant to accept the available information systems, which mean that these investments are extremely risky. Understanding why users choose to accept or reject an information system has proved to be one of the most challenging problems in this research area. Previous studies have focused on users' beliefs and attitudes regarding use intentions, but the results have, however, been both mixed and incomplete. In this study, I have used the Swedish youth? s use intention of mobile banking and a quantitative study was performed based on five different hypotheses derived from previous studies.

Our aim is to analyse and discuss Swedish sport federations´ view about talent. We are analysing material, mainly in digital form, with focus on the identification of talents, development of talents and talents in a wider perspective. The first one is about when and how federations identify talents. The second one is about how they work with development of talents, for example, what is the most significant aspect to develop young people to become successful athletes. The third one is about organizations questions, how they work to create an environment that enables Swedish athletes to become great in sports.

 We have chosen to write our thesis within a transport company. The work was carried out at DHL activities in Uppsala. DHL is one of the leading transport companies worldwide. Our interest lies in more efficient and advanced transportation and terminals, as globalization and new trends require effective solutions.The aim of our work is to explain the need for information technology applications in road haulage and associated terminal operations. Furthermore, we analyses terminal and applied information technology.

 We have chosen to write our thesis within a transport company. The work was carried out at DHL activities in Uppsala. DHL is one of the leading transport companies worldwide. Our interest lies in more efficient and advanced transportation and terminals, as globalization and new trends require effective solutions.The aim of our work is to explain the need for information technology applications in road haulage and associated terminal operations. Furthermore, we analyses terminal and applied information technology.

There are an increasing number of pupils leaving school with incomplete grades. Research indicates that the causes to this phenomenon may be individual- as well as school related and complicated to illuminate. The purpose of the study is to examine the processes of exclusion that have resulted in pupils´ incomplete degrees. Two research problems have been formulated. The first one is about the identification of exclusion and branding factors for pupils with incomplete degrees.

BACKGROUND: The nurse profession is nursing care and that includes leading and educate co-worker. In north-east Skåne a nurse started a study circle about pain for nursing staff at housing for elderly. AIM: The aim of this study was to understand the nursing staffs understanding about the study circle as a resource for their work with analgesia among elderly after participating in the same. METHOD: A qualitative approach was used and collecting data was done by a semi-structured focus group interview and two individual semi-structured interviews. The data was analysed by content analyses.

The purpose of this study was to investigate the problems of building a new region in the Southeast part of Sweden. The idea of a big south Swedish region is brand new; no former studies in this area have been done before. The main analytical focus of this study is legitimacy, identity and democratic credentials. The study has been carried out by interviews with several leaders in organizations working with the collaborations of the smaller regions in to the big region. The method of this study has been a single-case study and dialogue interviews.

My thesis is based on a qualitative study in which I have selected six professional teachers in a school in Greater Stockholm, and their views on the phenomenon of conflict management. My questions were the following.How teachers perceive the phenomenon of conflict in the world of school?What strategies do teachers use to resolve conflicts with students?In order to analyze my informants, I have chosen different books that deal with conflict man-agement, policy documents and books on the teaching profession meaning. Through my investigation I found that some teachers used tools and strategies through expe-rience and reflections, and resolve conflicts together or individually. My informants described that there are some teachers how choose to hide and pretend not to see the problem.

Sammanfattning Syftet med vår undersökning var att få syn på vad som utmärkte nyexaminerade lärares beskrivning av vad och hur de använder lärarutbildningen i sin profession, med fokus på de teoretiska momenten. Den dominerande bilden i tidigare forskning är att nyblivna lärare upplever många svårigheter under den första tiden i yrket. I det nya Lärarprogrammet från 2001 fanns en strävan efter att utbildningen skulle bli mer vetenskaplig och akademisk. Vi undersökte om lärare, examinerade från den nya utbildningen, beskrev att de hade nytta av de teoretiska momenten och om dessa på något sätt underlättade i vardagen. Vi har gjort en kvalitativ studie med halvstrukturerade frågor.

The aim of this paper is to examine how young men of foreign background are pictured in the realistic adolescence novels of 2009. In my process of work I have used a classical schedule for literature analysis from which I have worked out a few questions to use on my texts. The questions are related to the main characters and some of the most important minor characters ? all are young men with foreign background ? and focuses on aspects of for example where they live, who their friends are and what they think about and dream of.To put these pictures into a wider perspective I compare my results with the well known stereotype picturing of men with foreign background in media. I then discuss how or if this affects the young men?s picture of themselves and the majority society?s picture of them.

The aim of this essay was to look into and compare the experiences and opinions about the practice of 13 § LVM among persons that, through their profession, use the law.The questions we have been asking were; what experiences and opinions the individuals have about the paragraph in general, what they think about the cases when no application for LVM is made after a client has been taken in charge as directed by 13 § LVM, and of the fact that the majority of cases of LVM are initiated by the same paragraph. Another question was how the individuals think about the legal security in connection to 13 § LVM.The methods used are qualitative and we have interviewed individuals from different fields of social work that comes in contact with drug abusers.The findings from these studies include that care made out of the clients' free will is the main reason why an application is not made. It is also the reason to why many LVM initiates as directed by 13 § LVM for the reason that the districts above all try to help the clients without force. The economical aspects are repeatedly mentioned as another reason to the problems appeared in connection with 13 § LVM..

Arbetet består av en undersökning av förskollärare examinerade 2002 och deras första tid i yrket. Fokus i undersökningen har varit på lärarnas ambitioner och på svårigheter att förverkliga dessa. Tolkningen av materialet har varit att försöka förstå relationer mellan ambitionerna och svårigheterna. Övergången från lärarutbildningen till att arbeta i verksamheten, är den fruktsam för professionens utveckling? Det är ett fenomen jag undersökt.

The Swedish armed forces are facing a change, a change in both organization and profession. From a conscript military service system, the Swedish Armed Forces has changed to having full-time contracted soldiers. Conscript military service has a history of over a hundred years; it was introduced in 1901 and has survived two world wars and the Cold War.The Swedish armed forces have changed to have contracted soldiers. My reflection is whether the armed forces really have had time for this changes that the new professionalization has meant. Today the Swedish armed forces consists of contracted soldiers, soldiers who are employed full time and costs the armed forces a lot of money.