Duchenne Muscular Dystrophy (DMD) is a hereditary X-linked fatal disease that affects 1 in 3500 male births. It is the most common kind of muscular dystrophy in children and leads to death in the late teens or early 20s for many patients. The mdx mouse is a model of DMD that can be used to investigate experimental therapies. Overexpression of a glycosyltransferase, CT GalNAc, in mdx mice has been demonstrated to prevent the development of muscular dystrophy. Overexpression of another glycosyltransferase, LARGE, is currently being investigated as a treatment for another group of muscular dystrophies, the dystroglycanopathies. In this study, we overexpressed LARGE in mdx mice in order to investigate its effect on the development of muscular dystrophy.

Informationsteknik (IT) är en marknad som förändras snabbt. Att investera i IT kan därför vara kritiskt. Att ha en strategi för hur satsningar på IT ska göras kan minska risken för felinvesteringar på IT men strategin kan även ge andra fördelar. Att ha en IT-strategi innebär dock inte automatiskt att den ger fördelar. IT-strategin bör även användas.

The concept of leadership development plays an important role within the modern organization. As a result of the increasing interest in developing leadership competencies, investments in leadership development programs are becoming a common part of business strategies. However, the return on those investments is seldom evaluated. The reason for this is considered to be the complexity created by the many factors that influence leadership but have no relation to the program. This is a case study based on interviews with participants from a one-year leadership development program that was carried out at AB Previa.

The aim of this thesis was to study the view on workplace health promotion among leaders in elderly care, to see how their views can influence employee health. The research questions of this study were: How do leaders in elderly care define the term health? What conditions do leaders in elderly care experience that they need to maintain or improve employee health? How do leaders in elderly care experience their role in workplace health promotion?The thesis is done with a qualitative approach and is based on six partly structured interviews with leaders of care homes within Stockholm municipality. The results from the interviews were analysed against Aaron Antonovskys theories about the salutogenic model and sense of coherence as well as with previous research. The result from the study showed that the leaders´ had an awareness of the meaning with health promotion, however, they had not reached the stage where they implemented the health promoting thoughts in their actual work with health.

The research done in the field of product completeness/incompleteness is limited. The lack of research causes a knowledge gap in the retailing industry, concerning the actual effects on consumer choice, as well as on the overall store evaluation. This report tests the current theories of the subject, and also further aim to explore the effects of completeness/incompleteness on consumer's product choice. The results display an inconsistent effect on consumer's product choice when the completeness/incompleteness in a grocery store is tested. Some products benefit by being incomplete, while others show no such effect.

The aim of this thesis is to create an understanding of the incentives for forest companies to invest in reducing carbon dioxide emissions from deforestation and forest degradation, which is termed REDD. The Brazilian Amazonas was chosen as the base for the investment case. Brazil has the largest area of rainforest in the world, and also the biggest problem with deforestation. The Amazon region of Brazil comprises rainforest which is largely intact and unexploited. Accordingly, there is significant potential scope for prospective investments in a REDD-project, and so have a noteworthy impact in preventing deforestation.The research approach used the United Nation?s Clean Development Mechanism concept was used as a framework for ascertaining the investment costs in potential REDD-projects.

To sort, is the meaning of the word ?triage?. Triage is used at emergency departments to facilitate prioritization of patients according to the urgency of the chief complaint. The aim of this study was to investigate how the nurses experience the triage model at the emergency department at Uppsala university hospital.Twelve nurses were interviewed. The mean age was 40 years and the mean work experience was three years and four months.

The purpose with this essay is to examine if the Swedish government?s intentions regarding to the mental health care reform, have been fulfilled. We have classified the intentions into three categories, regulation, financing and responsibility for organizing the policy. The intentions have then been compared with the results of the reform.Our theoretical framework starts with a model, developed by Evert Vedung (1998). We use this model as a tool to examine the fulfillment of the mental health care reform.

Shopping malls have been growing in numbers during the last few decades. As an effect, consumers are increasingly placing a greater amount of their purchases under one roof. The problem is that stores within these malls have to fight for the consumers' attention in competition with all the other stores. Thus, making consumers noticing their store is critical for success. Creating attention through floor advertising could be a potential way of doing so.

This study aims to measure the effect of accounting conservatism and to identify thebusiness activities causing firms to undervalue owners? equity. To estimateaccounting conservatism, we have followed the hypothesis that no firm over time cangenerate a return greater than its cost of equity, i.e. CAPM. Thus, if a firm in factgenerates an excess return over time, we assume that the excess return is an estimateof accounting conservatism within that firm.The hypothesis originates from the corporate valuation model ?Economic ValueAdded®? which tries to adjust for accounting bias.

Numerical simulations play a vital role in both static and dynamic stability assessment of electric power systems and the foreseeing of voltage collapse. Simulations performed by Svenska Kraftnät(SvK) are mainly done in the specialized voltage collapse predicting software tool, SPICA and the more all?purpose software tool, ARISTO.The grid operators at SvK use SPICA to predict the maximum transfer limit at specified sections (in this report the section in concerns is the southern part of Sweden i.e. interface1 4). SPICA is mainly used as an online application by using actual states from the grid, these states update every quarter of an hour.This thesis is a continuation of the master thesis SPICA ? ARISTO JÄMFÖRELSE by Jakob Katzman and Johan Fält.

Background: This paper was performed by a student in the Public Health Sciences program at the University of Gothenburg as a mandate from the district administration (SDF) Askim-Frölunda-Högsbo in Gothenburg. The assignment was formed on the basis of a need for a new service with a family-centered approach in the form of a family center for families with children aged 6-12 years. The family center will be located in the Frölunda area.Aim: The purpose of this paper was to describe and deepen the understanding of the concept of a family center from a public health perspective. A particular focus was put on interventions that are aimed at children aged 6-12 years.Method: Walker and Avants (2011) model for concept analysisResults: The defined attributes that the analysis led to were the following: Collaboration, Health Promotion, Prevention and Support services and the Visitors. The created model case and the borderline cases showed a clearer picture of the concepts meaning.

People with chronic fatigue syndrome and their experience and need for care referred to Barbro Gustafsson's theory of acknowledgement and the SAUK-model..

City of Malmö has ambitions for the district Hyllie to become a demonstrative area ofsustainable urban development. As a part of this the following report aims to investigate the potential in using noise barriers combined with photovoltaics along Annetorpsvägen to generate solar electricity. To quantify the losses that shadows from buildings along the roadmight cause, a 3D-model of the area was constructed in SketchUp. This digital model made it possible to simulate shadows and how they change over the year. A reference model of a photovoltaic noise barrier (PVNB) was constructed and used to find the dates on which the solar cells are shadowed depending on building heights and positioning of the barrier.The results show that two lengths with a total distance of 400 meters is appropriate for applying photovoltaic noise barriers.

This master thesis is a study of the Swedish hydropower capacity to balance wind power. The Swedish government has decided that it should be possible to produce 30 TWh from wind power in the year 2020. The Swedish municipalities have to have plans for wind power plants with total yearly generation of 30 TWh. Wind power is an variable energy source that needs to be balanced by other energy sources. In Sweden the Swedish hydropower can be used for balancing a large scale introduction of wind power.