The problem of finding targeted medicine is a central problem in chemotherapy. From this point of view the ubiquitin-proteasome system is a highly promising Object in the pharmaceutical approach. Proteasome plays a critical role in cellular protein degradation, cell cycle and apoptosis regulation.Proteasome inhibitors are substances blocking the actions of proteasome. Cancer cells are more sensitive to inhibition of the ubiquitin-proteasome system than normal cells. Therefore proteasome inhibitors have the potential to be successfully used in the cancer treatment.The study aimed to test various substances to identify possible proteasome inhibitors with the IncuCyteTM FLR image system and fluorometric microculture cytotoxicity assay.

Animal art is one of the more mystical aspects of Scandinavian Iron Age culture. It has foremost been regarded in the light of art and style history. Interpretation has also ? mainly from the 1990s and onwards ? been made through iconographic analysis. But the problem here is that iconography requires textual analogy, something that the Scandinavian Iron Age lacks.The purpose of this paper is to lift some of the ?mystical fog? that engulfs the scandinavian animal art, by developing a method for interpretation of pre-historic images that evades the flaws in the iconographic method.

The aim of this study is to examine metaphors and what may be perceived as motif-circuits in Stig Dagerman?s play Den dödsdömde (The Man Condemned to Death) and the two short stories ?Den dödsdömde? (The Man Condemned to Death) and ?Mannen från Milesia? (The Man from Milesia). My intention is to discuss a single theme and identity-marks that unites all three works, using Paul Ricoeur?s The Rule of Metaphor (La mêtaphore vive) as well as the ?thematic critique? of Jean-Pierre Richard.What is metaphor for Ricoeur is for Richard themes (theme): an organizing principle, a sort of schedule around which a world is constituted. Hence, I find similarities between the motif-circuits, Ricoeur?s metaphor-theory and Richards?s themes.

Concept - detail - buildingStockholm International Fairs, new main entrance I studied at the KTH School of Architecture from 1995 to 2000. After completing my studies I wanted to work in an office that had a structural way of thinking and that knew the building process; I therefore chose to work for Rosenberg Architects. I have worked on a number of projects, among them several for the Stockholm International Fairs, from the Rica Talk Hotel and Hall AE, to the new main entrance.In the projects we undertook at the School of Architecture we had to identify and draw details that were central to our concepts. I have here identified some key details that we considered to be essential for the concept in a built project; the new main entrance of the Stockholm International Fairs completed in 2013. The entrance has complex logistics with multiple intersecting flows: exhibitors, employees, journalists, VIPs and others.

The Object with this thesis is to evaluate which of the catch crops oil radish and white mustard in combination with establishment method, give the most effective nitrogen uptake. The main purpose of the catch crops is to reduce leakage of nitrogen. They are sown after the main crop and killed before the next crop. In Sweden the farmers gets subsidies to establish catch crops. The thesis is limited to the trail L3-9010 sited at HS- Malmöhus, Borgeby Gård, 237 91 Bjärred, Sweden, 2007. Only treatments with oil radish, white mustard and the reference treatments were studied.

In the debate on laying hen welfare, and specifically housing conditions, the main focushas been on physiological and behavioural measures. What is lacking is knowledge of howthe hen experiences the situation ? her state of mind.This study is an attempt to gain insight into the private mental states of former batteryhens. It uses a cognitive bias method based on spatial judgement, i.e. judgement of aambiguous stimulus placed spatially in between a reinforced and an unreinforced stimulus.This method has previously shown differences in judgement by animals in enriched versuspoor housing.

Heart failure is an illness that requires life-long treatment and often affects everyday aspects of a person?s life. Self-care is a significant part of the treatment. Good self-care resources make it possible for people with heart failure to make the lifestyle changes they often need to maintain or improve their level of health. Self-care means having knowledge of and being able to recognize the symptoms and signs of deterioration that can occur with heart failure, so that the person can take appropriate measures ? and it also means knowing when it is time to seek professional help.

Begreppet landskap kan betyda både utsiktslandskap, så som det används på engelska , och område, region, som är grundbetydelsen i de germanska språken. Torsten Hägerstrand introducerade i början på 1990-talet begreppet förloppslandskap, som vänder sig mot ett statiskt betraktande av landskap och istället tar fasta på landskapets processer. Målet med denna litteraturstudie är att presentera en översikt av förloppslandskapets idéer. Syftet är att med detta som bakgrund föra en diskussion kring förloppslandskapets relevans i dagens planeringssituation. Europeiska landskapskonventionen företräder en landskapssyn där samspelet mellan natur och samhälle betonas, men till skillnad från förloppslandskapet så är fokus inställt på människans upplevelse.

An absolute majority of all Swedish children begins to attend preschool at some point between the age of one and five. The acclimatisation to preschool means a great change in every small child's life. They leave all that is well known, the parent and their home, to face a whole new environment with new kids and adults to get to know and learn to trust.The purpose of this study has been to find out how the professionals in preschool reflect upon the child's acclimatisation at preschool. More specifically we wanted answers to how the preschool teachers, in their work with the child's acclimatisation, relates to the today, in preschool, much debated relationship between the two perspectives care and pedagogy.This qualitative study is based on ten interviews with preschool teachers at different preschools in a small town in Sweden. The analysis is based on a presentation of the interview material compared with earlier research and the theoretical aspects we have chosen, which are Bronfenbrenners Ecological Systems Theory and the Object Relations Theory.While working with this paper it has come clear to us that there is no explicit or common definition of the concept of care within preschool, while there is a clear definition of the concept of pedagogy.

From a view of health strategies and techniques this thesis wants to throw a light on how the individual in its"health thinking"is governed. A thinking that, according to the author, can lead to a new way of governing as in municipal activity, an activity whose focus is on health and ill-health. The study is done whit a theoretical approach of power, with qualitative interviews as method and analysed from a perspective of Governmentality. The Object for the study is Socsam and Rehabrådgivarna in Finspång. Socsam is a local project, and their main task is to create cooperation between health- and medical services, social services and social insurance.

During a major part of modernity the concept of identity was something that in many ways was predetermined for the individual. People in general remained in the same social spheres as the generations before, shared common religions and beliefs and where more or less bound to a geographic area. Identity and lifestyle was something that was adapted quite unreflected from habit and tradition. Though, during the cultural modernisation process that took place in the twentieth century, previous shared patterns of interpretation vanished and became individual.  Finding references, constructing an identity and establishing a self became individual.

The Object of the thesis is to propose a new lighting plan for the square Fyristorg in Uppsala, and to describe the process which have led to it. It all started when I choosed the place together with the municipality of Uppsala. I have been doing research and analyzed how the place and it´s existing lighting works both during different times of the day and also in the evening. After researching the place and it´s existing lighting I´ve decided to put up the following goals fot the new lighting design. 1. The general light level of the place shall be experienced as higher than today. 2. The light level of the place shall be adapted to the light levels of surrounding places. 3. The lighting shall be free from glare. 4. The lighting shall be adapted to people passing by. 5.The lighting shall be adapted to the surrounding architecture. 6.

Title: The competent teacher-external and internal frameworks and their influence on educational praxis. This thesis is about what kind of approach a teacher (may) consider when he is facing parameters that he can not do anything about, in this case represented by political, educational och social frameworks. One of the things a teacher can do to adapt to the situation is to see what possibilities he has to develop and expand his topic. The study is built on action research and was carried out during a nine months period on an upper secondary school in Malmö, Sweden. The Object of reasearch is myself as a teacher and in my result I describe how various educational situations were handled.

The purpose with this thesis is to understand the relationship between a square?s design and its function as a public meeting place, were Sundstorget in the city of Helsingborg is used as a study Object. The architect Jan Gehl developed a theory of people?s outdoor activities in his book Livet mellem husene (1996). He divides the activities in three categories; 1) necessary activities, 2) optional activities and 3) social activities, which are differently affected by the place?s design.

Syftet med denna studie är att undersöka hur några elever i årskurs 1 skapar förståelse för vad en teknisk artefakt är och vidare hur eleverna ges möjlighet till detta genom att läraren använder variationsmönster under ett lektionstillfälle. Materialet har samlats in genom en learning study vilket innebär att vi har genomfört en praxisnära undersökning. Vi har i studien agerat både forskare och lärare; observerat, planerat och bedrivit undervisning samt analyserat empirin. Vi har studerat tre lektionstillfällen i tre olika grupper med fokus på att tillsammans med eleverna skapa en definition av vad en teknisk artefakt är. Med hjälp av för- och eftertester har vi även undersökt elevernas uppfattningar om tekniska artefakter före och efter lektionstillfället.