The problem of finding targeted medicine is a central problem in chemotherapy. From this point of view the ubiquitin-proteasome system is a highly promising object in the pharmaceutical approach. Proteasome plays a critical role in cellular protein degradation, cell cycle and apoptosis regulation.Proteasome inhibitors are substances blocking the actions of proteasome. Cancer cells are more sensitive to inhibition of the ubiquitin-proteasome system than normal cells. Therefore proteasome inhibitors have the potential to be successfully used in the cancer treatment.The study aimed to test various substances to identify possible proteasome inhibitors with the IncuCyteTM FLR image system and fluorometric microculture cytotoxicity assay.

This pre-study investigates the possibility of U-value measurements through an acoustic method. A hypothesis about an acoustic model built on acoustic theories combined with U-value theories is presented to answer the questions: ? Can U-value theory be combined with acoustic theories? ? Can the coefficient of heat be affirmed trough an acoustic measurement? The idea for this dissertation begun with a logical idea in mathematical similarity, between the coefficient of heat transmission units and sound intensity units. The U-value theory is based on assumptions such as initial resistance for inner walls and initial resistance for outer walls. The resistance in the material is interpreted through sound intensity theory. The argument is built upon mass law theory, which means if the frequency or thickness of the material layer doubles it implies an increase of sound reduction by 6 dB.

There is a shortage of locally produced high quality protein concentrates in Europe andSweden. Local production would decrease the dependency on imported soybean and meet thedemand for organically grown feedstuff from ecological dairy farmers. Field bean (Viciafaba), peas (Pisum sativum) and sweet lupin (Lupinus angustifolius) are good alternatives tosoybean, but contain anti-nutritional substances (ANS) that could reduce their use as proteinconcentrates in dairy cow diets. The aim of this literature study was to review which ANSfield bean, peas and sweet lupin contain and whether they affect dairy cows negatively.Trypsin inhibitors and Chymotrypsin inhibitors (TI) were present in all three crops. TI couldbecome inactivated and degraded in the rumen, but due to the high passage speed of thedigesta, most TI left the rumen in an active state.

In this Bachelor thesis an animal bone material from Västergarn parish is analyzed and discussed. The purpose of this thesis is to gain more knowledge about the Viking Age/Early Medieval Västergarn. Västergarn has a few remains from former days which have been discussed throughout the years and are still a bit of a mystery for archaeologists. The main focus is to inquire into whether Västergarn was an urban, complex society or a rural settlement. This will be done by studying the animal husbandry from the property of Snauvalds 1:2.

Hemoplus® (Sarstedt, Nümbrecht, Tyskland) is a guaiac-based fecal occult blood test developed for human medicine. Guaiac-based tests make use of the pseudoperoxidase activity of hemoglobin so the test is not specific for human hemoglobin and can therefore be used in veterinary medicine. Peroxidase-containing foods such as meat (hemoglobin and myoglobin) can cause false-positive results of the test. To ensure that a positive result is not caused by diet, it has been suggested that canine patients should be fed a meatless diet for a few days prior to fecal occult blood testing. The aim of this study was to evaluate the effect of commercial dog food on guaiac-based tests. In this study fecal samples from healthy dogs were analyzed with Hemoplus®.

This study has been done in order to map the supply of vegetarian and vegan food products in Sweden for business clients and consumers. A total of 665 food stuffs were found and classified into six categories. The biggest category was meat substitutes with 302 products and the second largest category was sandwich spreads with 150 different products. Within the remaining categories a varied number of products were found; 86 beverages, 64 cooking accessories, 34 milk free ice creams and 29 plant based yogurts. Of the meat substitutes were 28 only available for business clients.

Alzheimers sjukdom (AD) är den vanligaste formen av demens och kännetecknas av intracellulärt neurofibrillärt trassel (NFT) bestående av proteinet tau och extracellulära plack, uppbyggda av peptiden amyloid beta (A?). En växande skara studier har börjat peka mot att AD är en hjärnspecifik typ av diabetes. Insulinresistens följt av hyperinsulinemi och hyperglykemi är kännetecken för diabetes mellitus typ 2 (DMT2) och har visat sig vara en riskfaktor för AD. Insulin, ett hormon som kontrollerar glukoshomeostasen i perifera nervsystemet (PNS) och är viktigt för minne och inlärning, transporteras över blod-hjärnbarriären i en mättnadsbar transportmekanism och dess koncentration i centrala nervsystemet (CNS) minskar vid DMT2 och AD.

This paper deals with the late Viking age/early medieval grave field in Björned, Torsåker parish, Ångermanland County in northern Sweden. The grave field in Björned is rare because it has all the signs of being Christianized before the surroundings. This awakes questions such as if the people of Björned came from another place and brought the religion with them or if someone else did that for them. To find these answers I have analysed the stable isotope ratios [delta]13C, [delta]15N and [delta]34S in human bone collagen. Through these stable isotopes we can not only see what the people consumed but also where their food had its origin.

The Effects of dietary biotin supplementation on hoof health in Swedish dairy cows - a controlled cohort field study. The aim of the present degree project was to investigate the effects of biotin supplementation on hoof health in dairy cows. The experiment was performed as a controlled cohort study in three commercial farms in western Sweden from January 2002 to October 2002. The cows were all housed in cubicle systems with transponder concentrate feeding systems. Within each farm the cows were allocated to either biotin or control treatment. The biotin groups received 20 mg of biotin per cow and day, starting 14 days before expected calving.

Beans are a global source of plant-based protein, and in some countries, they constitute a primary source of protein intake. With ongoing climate change, including rising temperatures, it is necessary to adapt beans to ensure a reliable food supply. An important mechanism that many plants have, to cope with high temperatures, is cooling through transpiration. During transpiration, stomata open and release water vapor. Water molecules use heat energy from the leaf to convert into gas, thereby cooling the leaf.

This report discusses the development of an autonomous system that can travel a distance of atleast 30 meters on two wheels. The system, the robot, detects black lines and stops if one isdetected. A remote control can be used to start and stop the robot. The robot is constructed ofmainly steel with smaller, more detailed, parts in plastic. A significant amout of time has beenused to enable the robot to balance on its own.

Obesity is a growing global health problem among both humans and cats with the risk of several medical conditions as a result. This can be detected and prevented by body condition assessment methods in order to visualize and detect possible or potential weight problems in cats.To achieve the best results, owner and cat should be introduced to this as soon as possible in their contact with veterinary care.Purina Body Condition System and Walthams Feline Body Mass Index are both morphometric assessment methods that are quick, relatively cheap and simple to perform. 20 cats with owners and a veterinary nurse student participated in a study to compare pet owners and a veterinary nurse student's assessment of the Purina Body Condition System and WALTHAM's Feline Body Mass Index. The body condition assessment methods were compared with each other, and it was investigated which method was preferred, the body condition distribution among the studied cats and if long-haired cats' body condition was more often misjudged. Results of the study showed a significant difference between pet owners and the veterinary nurse student's assessment of Purina BCS with a difference in median of 1.

The dairy market will change importantly in the coming years. The quota system, which has regulated the European dairy production, will disappear in 2015 and the European dairy market will then be importantly affected by the volatility characterizing the dynamic of world prices. Besides this, the global demand of dairy products is expected to increase due to the growing world population. Farmers in countries such as the U.S. and New Zealand, when compared to Swedish farmers, show greater familiarity and experience with risk management tools.

There is an uncertainty in the market for grain forcing the meat/milk producers to review alternative feeds to a larger extent, in order to get control over the feed costs. This has led to that the meat/milk producers need to have a good knowledge regarding how the different feeds influences the animals and which technical equipment to use for handling. For those that produce their own feedmix, there is a need to put interest in new crops and their characteristics to be able to get the knowledge of what is required for their own production. It is beneficial to keep an open dialogue with advisors to be updated in new crops and new technology for feeding. When mixing feed at farm level, the legislation is not very clear since it the target group is large scale mixing plants. We have brought up the most important rules and regulations from the EU parliament Council as well as the ones from the Swedish Board of Agriculture (SJV), regarding feed mixing on farm and factory level. We have studied beans and pea at two different moisture levels, in order to evaluate how the moisture level affects the distribution of particles when milling with a plaitmill and a hammermill.

Gastric and intestinal disorders are common and costly human health problems worldwide. Helicobacter pylori are a gram-negative, pathogen bacteria and the most common cause of duodenal and gastric ulcer in the stomach the intestinal mucosa. Prolonged infection and colonization can lead to chronic gastritis and stomach cancer. H. pylori are present in the gastric and intestinal mucosa of half of the world population and a relation between infection and low socioeconomic status has been shown.