Background: Chemotherapy and radiation resistance are major causes of failure in cancer treatment. The response to treatment in cancer cells depends on several mechanisms and pathways such as Janus kinases-signal transducers and activators of transcription JAK/STAT pathway. STAT1 was the first described transcription factor in the STAT family. STAT1 is activated by stimulation of signaling proteins such as type II interferon (IFN- ?) and the activated STAT1 translocates from cytoplasm to nucleus.

This Master Thesis has been carried out in cooperation with Ursus Medical AB (URSUS) which markets, assembles and sells the Rotex Screw Needle Biopsy Instrument ®. The instrument is delivered with an instrument holder. Customers had expressed dissatisfaction over that they needed to use two hands during a biopsy procedure, which resulted in a project to develop a new instrument holder.The project aim was to create concepts for how the new instrument holder should be designed, with focus on the mechanics. The new instrument holder would build on the existing basic principle that the screw needle and the cannula were screwed into the tissue. The thesis work would result in a technical solution and a functional prototype of the chosen concept.To achieve this, a generic product development processes were used and began with a comprehensive literature review.

During the recent financial crisis there has been an intense debate regarding small enterprise?s possibilities to borrow money. Statements from interest groups and results from surveys among Swedish non-financial companies indicate that their situation has worsened. Credit worthy enterprises that under normal circumstances would not have any problems getting financing are now facing financial difficulties. In contrast, an economic report from the Bank of Sweden concludes that Sweden does not suffer from a severe credit rationing due to the financial crisis.

This study examines how perceived accessibility and distance decay interact with social and psychological factors in the use of local sharing initiatives. The study is conducted as a case study of Fixoteket in Gothenburg, with Fixoteket in Hammarkullen as primary focus. Through five semi-structured interviews and five participatory observations at Fixoteket in Hammarkullen, Ranneberg and Fr?lunda, this study analyses which factors function as barriers and enablers for participation, as well as what benefits the initiative generates beyond resource efficiency through sharing.The results show that social factors such as community, a sense of belonging, and social rituals around visits constitute the primary drivers for participation, while psychological barriers, related to competence, shame and digital exclusion are the most significant barriers. Distance decay proves to be a relative, rather than an absolute phenomenon, where visibility and social presence dictate the significance of physical distance.

This thesis is a feasibility study into how Fresenius Kabi may rationalize their destruction process in regards to cost, recycling, and work environment. The two main objectives are to identify scrap flows and the possibility to improve or replace the equipment that is now carrying out the physical scrapping. The flow has been visualized by a flow chart of the material and communication. A chart of the problem established to visualize where improvements are necessary. Based on the problems proposals are presented on how to improve the flow thru the plant.During analyze of the physical scrapping equipment it was also necessary to take a deeper look at how they are carrying out there work today, how does the procedure look like, working environment and where are the weaknesses.

System Andersson AB is a company located in Jönköping that works with developing computer systems for the mechanical engineering industry. As of today, when this report is written, the company is working on the development of a new Manufacturing Planning and Control (MPC) system. This new system aims to create not only a user friendly interface but also a modern, stylish interface. To achieve this, the company has decided to work with a, for them, new application framework; Windows Presentation Foundation (WPF).System Andersson is well known for developing systems for different kinds of touch screens, this project is no exception. For this new user interface the company wishes to implement different types of Drag&Drop functionality.

Many companies today are investing in various computer-based tools to support their planning, decision making or communication processes. However, end users are often reluctant to accept the available information systems, which mean that these investments are extremely risky. Understanding why users choose to accept or reject an information system has proved to be one of the most challenging problems in this research area. Previous studies have focused on users' beliefs and attitudes regarding use intentions, but the results have, however, been both mixed and incomplete. In this study, I have used the Swedish youth? s use intention of mobile banking and a quantitative study was performed based on five different hypotheses derived from previous studies.

Kisa Courthouse in the south of ?sterg?tland is a house built in the early 19th century with a typical neoclassical style. With clearly regular symmetrical wooden facade scheme with a central main entrance. The main entrance is a wooden double door with richly decorated portico. the crown moulding above the door consists of a band of dentils with a cornice moulding at the top.

Land consolidation is a major problem in many countries in Europe. In Sweden, mainly the state of Dalarna, there is a strong consolidation of forestland, probably the strongest in all of Europe. The consolidation is a big obstacle for forest management and ownership questions due to the often long and narrow strips of land. One of the main reasons for land consolidation in Dalarna results from the heritage procedure, were land is divided between all of the inheritors. To improve the consolidation large surveys in the consolidated villages in Dalarna are carried out. Many laws have to be followed due to the survey.

Our aim is to analyse and discuss Swedish sport federations´ view about talent. We are analysing material, mainly in digital form, with focus on the identification of talents, development of talents and talents in a wider perspective. The first one is about when and how federations identify talents. The second one is about how they work with development of talents, for example, what is the most significant aspect to develop young people to become successful athletes. The third one is about organizations questions, how they work to create an environment that enables Swedish athletes to become great in sports.

The theses discuss information seeking with a focus on Google and social networks. Students attending the librarian program in Lund have been examined by means of two methods; diaries and information horizons, where they had to solve a specific assignment. The information horizon as a method contributes to getting a structural perspective on the information search process instead of viewing information search as a procedure. Information horizons use social network analysis.The aim of the theses is to investigate the importance of the social network in information search, with a particular focus on Google as a search tool. Our hypothesis is that Google acts as a compensator to the social network when the students search for information and in the educational program.The research indicates that there is no direct correlation between usage of the social network and usage of Google.

 We have chosen to write our thesis within a transport company. The work was carried out at DHL activities in Uppsala. DHL is one of the leading transport companies worldwide. Our interest lies in more efficient and advanced transportation and terminals, as globalization and new trends require effective solutions.The aim of our work is to explain the need for information technology applications in road haulage and associated terminal operations. Furthermore, we analyses terminal and applied information technology.

 We have chosen to write our thesis within a transport company. The work was carried out at DHL activities in Uppsala. DHL is one of the leading transport companies worldwide. Our interest lies in more efficient and advanced transportation and terminals, as globalization and new trends require effective solutions.The aim of our work is to explain the need for information technology applications in road haulage and associated terminal operations. Furthermore, we analyses terminal and applied information technology.

The subject of this bachelor thesis is discrimination and unfair treatment in the employment process where employers discriminate against job applicants. The purpose of this study and research questions is to investigate and clarify the legal protection available against discrimination and unfair treatment of pregnant women and persons on parental leave during the employment process and how this protection differs between men and women. This thesis highlights the Swedish law and EU law regarding discrimination and unfair treatment of individuals. The concept of discrimination and its requisites will be accounted for and exemplified by case law. This statement will be analyzed along with the relevant case law of the EU-court and the Labor-court.

There are an increasing number of pupils leaving school with incomplete grades. Research indicates that the causes to this phenomenon may be individual- as well as school related and complicated to illuminate. The purpose of the study is to examine the processes of exclusion that have resulted in pupils´ incomplete degrees. Two research problems have been formulated. The first one is about the identification of exclusion and branding factors for pupils with incomplete degrees.