Introduktion: I juli 2012 uppdaterades regelverken för farmakovigilans inom Europa och flera förändringar gjordes i de bestämmelser som rör säkerhetsstudier på godkända läkemedel. En sammanställning av dessa behövdes för att lyfta fram viktiga bestämmelser och ge en tydligare överblick av de myndighetskrav som berör PASS (Post-Authorization Safety Studies) och PSP (Patient Support Programs). Syfte: Projektet syftar till att analysera och tolka regelverk och riktlinjer gällande PASS och PSP inom Europa samt utreda vad som gäller för PASS i de skandinaviska länderna. Detta för att lyfta fram viktiga bestämmelser och underlätta tolkningen för berörda företag. Material och metoder: Huvuddelen av projektet bestod av en litteraturstudie där fokus låg på lagar och riktlinjer inom Europa. Informationsinhämtning skedde även genom intervjuer med personal på Bayer AB och Läkemedelsverket. Jämförelser har sedan gjorts mellan svenska, norska och danska regelverk. Resultat: Myndighetskraven för PASS och PSP skiljer sig åt i vissa avseenden.

The aim of this study was to investigate the knowledge of caries and gingivitis among third to fifth grade school children. A questionnaire was distributed to 117 children of a primary school in the south of Sweden. The result of the study indicate that the children had good knowledge regarding development and prevention of caries and gingivitis. However, the children did not know the meaning of the words caries and gingivitis. The children also appeared to lack important information about dietary measures to achieve good dental health.

With a changing climate, we can expect higher temperatures and more precipitation in Sweden.As the temperature increases, new weed species are expected to migrate in from more southerlylatitudes, resulting in requests for new techniques for weed control. In addition, we might see agreater number of weed species and higher biomass production due to increased concentrationof CO2 in the atmosphere.Increased understanding of the biology of specific weed species will become more importantin future weed control. This will help to control the weeds more efficiently. Higher prices onpesticides and a public demand for reduced use of pesticides make growers more inclined to usemechanical weed control on a larger scale and to a greater extent prevent weed establishmentbefore sowing. A well-planned crop rotation is the most important preventive measure, whichmight also include delayed sowing, and dark harrowing and sowing.Research takes place on many levels within the weed area and several alternative methodsare being developed.

We conducted this study because a new school reform begins in 2011. Our study is in between 1960 - 2011. The survey methodology is the following; we use literature, previous studies and curricula. Rating has returned to a more equitable system. This means that the range has decreased in each grade level. Industry has been involved and affected programs and curricula. Short courses have disappeared and GY11kommer to tighten eligibility requirements. This places greater demands on schools and students. The new grading scale will be fairer to the students. The courses have been following the development of society. It is also true that businesses have had opportunities to customize programs for their purposes, so that they have professionals with the basic knowledge they need.

During the year of 2008, a powerful earthquake hit the southern part of Iceland, which changed the geothermal conditions in the area around the city of Hveragerdi. Elevated soil temperatures in a nearby forest plantation have contributed to a unique opportunity for researchers to study how an increased soil temperature affects the boreal forest ecosystem, something that partly can be connected to the climate changes which are happening today. The boreal forest is representing a carbon sink and a buffert for the emissions that occurs. Changes in this ecosystem will for that reason contribute to major impact for the global carbon cycle. To study the impact of how elevated soil temperatures affects different processes in a plantation of Sitka spruce, studies were made on the photosynthesis of the trees and the respiration from the soil.

Milkability or ease of milking, has higher importance today for Swedish dairy cattle producers after the introduction of milking parlours and automatic milking systems. Milkability is the cow?s ability to quickly milk out and be completely milked. There are several measures of milkability available. Today the farmer measures the traits subjectively in relation to the conformation scoring of the cow 30-270 days after her first calving.

The effects of the deregulation of the electricity market 1996 in Sweden on short-term hydropower regulation are unknown. This report investigates patterns in subdaily regulation in the Ångerman River Basin during the period 1993-2011. Differences in subdaily flows and zero flow events between the periods 1993-1995 and 1996-2011 were studied by analyzing hourly data from 8 regulated and 8 unregulated locations with four subdaily flow variation indices. No correlations between the market deregulation and the regulation intensity in the Ångerman River basin were detected. The number of days natural ranges of variability were exceeded and the magnitude of subdaily variation were significantly higher at regulated locations.

Horses respond individually to challenges, and the possibility to use these reactions to evaluate equine temperament with an objective instrument would have several advantages. Horse welfare could be improved by making it possible to find individuals best suited for a specific use, and understanding of the development of abnormal behaviours, such as stereotypies, could be increased. Management routines and training could be adjusted tosuit each individual horse and it could facilitate the selection of individuals appropriate for breeding. There are also economic implications, as horse buyers consider temperament important and after evaluating temperament, money can be spent solely on specific horses with all the right qualities. During the last decade, many attempts have been made to measure different aspects of temperament in horses, and the first aim of this project was to look at these studies and see which methods were used and which temperamental characteristics they measured.

During football games neuromuscular fatigue occuring following eccentric movements such as sprint, jump and run that occur during games. To avoid injury, overtraining and performance decreases, it is important to know when players are recovered. The aim of the pilotstudy was to investigate physiological changes that occur during football matches and if they affect the recovery pattern after several games in professional football players. The method was divided into two sub-studies in which 12 professional footballers, in substudy 1 performed counter movement jump (CMJ) and drop jump (DJ) from 40 cm and fill out a recovery form for muscle soreness 36 hours before, 12-16 and 60-64 hours after 11 different competetive games. Blood samples were taken on the players in connection with one match to examine the activity of muscle enzyme creatine kinase (CK) and lactate dehydrogenase (LDH) of the players.

Abstract Background: More and more people receiving palliative care in the home, leading to increased responsibility for the next of kin. Being a caregiver and at the same time next of kin is a complex situation for everyone involved. Next of kin´s everyday life changes drastically when everything revolves around the one who is seriously ill.Aim: To describe next of kin´s experiences of being caregivers to a palliative sick person at home. Method: A literature review in which eleven qualitative scientific articles were analyzed and summarized. Results: The results revealed three themes; experience of support, experience of changes in life and experience of strategies.

Each year approximately 2,000 new detailed development plans are accepted in Sweden. When an area is covered by a new detailed development plan, it is often necessary that land has to be acquired to adjust the property units to the new plan. The owner conditions of the property units can usually be adjusted through negotiations between the seller and the buyer. But in some situations, when no agreements can be reached, it is possible to use coercive measures to purchase the land. Compulsory purchases are only permitted when certain legal criteria?s are met.

The subject of this bachelors degree project is an interior layout for road ambulances.Landstinget Västernorrland (LVN) wanted a layout concept that would be used to com- municate their design intentions to the ambulance producers during their purchase process.Designing ambulance interiors is an extremely complex process since there so many fac- tors to take into consideration. It ?s not just about taking the equipment and place it where there is space left in the cabin. You have to start with the user in focus and the tasks that are to be performed in the ambulance environment.It ishard to find design solutions that will fit 100% of the ambulance personnel?s working routines for 100% of the tasks.

CSR - "Corporate Social Responsibility" is a concept that in recent years has become of bigger importance for companies. Even at McDonald's, which quickly grew into today's 217 restaurants, with up to 430 000 visitors daily. We have investigated how the McDonald's CSR work has evolved over time, how it looks today and what has influenced this development. Things that have influenced McDonald's and led to their CSR work proved to be scandals and changes in legislations. The PR value of working with CSR has also increased and a lot of the CSR work has shown to be economically viable.

Ungulates are causing conflicts between stakeholders due to browsing damage on forests and agricultural crops. At the same time there is a big demand of keeping high ungulate densities for sports hunting and recreational purposes. Movement patterns of ungulates are strongly correlated with forage availability. Therefore, measures affecting forage quantity and distribution might be a tool to reduce the economical losses in forestry without decreasing the ungulate densities and thereby decrease the conflict between different interest groups.This study investigated the potential biomass production and utilisation of marrow-stem kale (Brassica oleracea var. medullosa), at game fields in Misterhult, Sweden, as well as browsing effects on adjacent forests.

This project has been about making a design suggestion for a boat accessory that adjuststhe distance between a sail-or motorboat and the dinghy, which is connected by a rope inthe stern. Today this is all done by hand and can lead to problems when it comes tostressful situations such as harbors and narrow passages.A company called Sailsafe came up with the idea and the construction, which they alsohave tested. I found them through an acquaintance at Dacat AB where I did an internshipin the fall of 2010.Using sketching as the primary tool I?ve worked in an almost-real design project with theaim to develop my skills and give the company a relevant design suggestion. Dacat thenhelped me with a 3d model in Alias, which was printed in 3d and painted in thepaintworkshop at school..