Alternative splicing is a process that partly rejects the common definition of a gene ? that one gene codes for one specific protein. By variable combination of coding regions (exons) and exclusion of non-coding regions (introns), formation of several different mRNA-transcripts, and consequently several different proteins, can derive from the same gene. Alternative splicing is an important condition for the development of complex life forms, but it is also a highly sensitive process and inaccurate splicing is the cause of approximately 15 % of mutations that cause genetic diseases. This article presents four genes, BRCA1, BRCA2, ER? and ER?, and inaccurate splicing of these genes increases the risk of developing cancer, particularly breast cancer and ovarian cancer.

Denna uppsatssyfte var att ta reda på vilken kännedom som finns om de svenskanäringsrekommendationerna hos människor på ett antal svenska arbetsplatser. Syftet har även inne-fattat att ta reda på huruvida man använder sig av denna kännedom eller inte.Metod: Enkvantitativ ansats i en tvärsnittsstudie har använts i denna undersökning och hundratio enkäter har blivit besvarade. Dessa enkäter har analyserats både kvantitativt och kvalitativt.Resultatetvisade att majoriteten av respondenterna inte kände till de svenska näringsrekom-mendationerna. Majoriteten var också omedvetna om hur den procentuella energifördelningen såg ut. Jämförbart med tidigare studier så underskattade männen rekommendationerna för grönsaker medan kvinnorna hade mer kännedom om rekommendationerna som helhet.

?Tollarsjuka? is a disease with a suspected immunopathological background seen in Nova Scotia duck tolling retrievers. Pyrexia, lameness, stiffness and joint- or musclepain are typical clinical signs. The purpose of this study is to describe case histories from dogs with a possible evidence of ?tollarsjuka?. 18 private dogs were included in this report. Generalised stiffness, lameness and fatigue were the most frequent manifestations of the disease.

Background: Chemotherapy and radiation resistance are major causes of failure in cancer treatment. The response to treatment in cancer cells depends on several mechanisms and pathways such as Janus kinases-signal transducers and activators of transcription JAK/STAT pathway. STAT1 was the first described transcription factor in the STAT family. STAT1 is activated by stimulation of signaling proteins such as type II interferon (IFN- ?) and the activated STAT1 translocates from cytoplasm to nucleus.

Title: Creating meetings - a study in interactionism and creating music. In this study I had my focus on teenagers in a school class. My aim was to explore how pupils experience the processes of creating music together and how they choose to organize their interactions during these creative processes. As analytical tools I used sociological and sociopedagogical concepts and theories. Interactionism provided models toward individualization as well as socialization, related to learning, knowledge and creativity.

REFERATPå en ridskola finns hästar i varierande åldrar. För personalen är de äldre och rutinerade hästarna en stor trygghet, eftersom de kan sitt arbete utan och innan. Denna trygghet är ovärderlig och på så vis har den äldre hästen en viktig roll på ridskolan. Omvårdnaden och däribland utfodringen av den äldre hästen är därför mycket viktigt för att hålla hästarna i gott skick.Det primära syftet med detta arbete var att göra en fältstudie på några svenska ridskolor för att ta reda på eventuella skillnader i energi- och proteinintag mellan de äldre och yngre lektionshästarna. Det sekundära syftet var att undersöka vilka faktorer som kan påverka den eventuella skillnaden mellan åldersgrupperna.Studiens frågeställningar var: Utfodras äldre hästar annorlunda jämfört med yngre hästar på ridskolan med avseende på energi- och proteinintag? Finns det skillnader i utfodringen mellan de äldre och yngre hästarna med avseende på fodermedel?Studiens hypoteser var: Den äldre ridskolehästen har ett högre energiintag än den yngre.

Background:Life-cycle costing (LCC) is an investment calculation that takes intoaccount operating costs throughout the investee lifecycle. LCC calculations are mainly usedto evaluate investments that have no revenue side. Attempts to apply the LCC calculations forbuilding-related investments have occurred since the 1980s. Despite the advantages ofusing LCC calculations, use has not passed through in full. The main obstacles have beenidentified as a lack of relevant input data, and insufficient experience of workingwith LCC calculations.

 Enligt tidigare undersökningar har vanadinföreningar visat sig ha insulinliknande effekter både in vitro och in vivo. Syftet med detta examensarbete var att prova ut en teknik för att testa effekten av vanadinföreningar på två olika celltyper: adherenta celler (AA-celler) och suspensionsceller (K562-celler). När insulinet binder till sin receptor på cellytan är det starten på en biologisk respons. Insulinreceptorn är ett tyrosinkinas som transporterar fosfatgrupper från ATP till tyrosin på sin egen peptidkedja. De aktiverade tyrosinkinasreceptorn kan aktivera ett antal signalmolekyler, bland annat proteinkinas B.

Two of the main approach roads into the city of Enköping are Salavägen and Stockholmsvägen. They are connected to each other through the street Bangårdsgatan in the roundabout Salatullen and crossing Fannakorset, respectively. These crossings are from time to time heavily loaded, which is why the municipality plan for a new street in parallel to Bangårdsgatan. The traffic will then be spread out and is thereby reducing the density. The new street is actually an extension of the existing Mästergatan, a side street to Salavägen, to the east and connecting it to Stockholmsvägen or a street nearby.The purpose of this Master thesis is to show how the new street can be drawn in order to discharge the traffic in the area between the roundabout Salatullen and the crossing Fannakorset.

Oilseed rape crops are an important in southern Sweden because of the high intensity of wheat growing. Pollen beetles are the most important pest in oilseed rape and causes often economic losses. Therefore it?s of great importance that we can control the population density, e g by using insecticides if necessary, to avoid mayor yield losses. In year 2000 pollen beetles were numerous in the province of Östergötland. The farmers sprayed with insecticides several times, but with low effects on the beetles. Field trials and laboratory experiments showed that pollen beetles had developed resistance against pyrethroids.

Bakgrund: En familj som lever med ett barn som har autismspektrumtillstånd påverkar dem och hela deras livssituation. Barnet behöver särskilt stöd av föräldrarna under hela deras levnadsår. Barn med autismspektrumtillstånd är personer som har individuella behov och dessa kan variera stort. Enligt tidigare studier som inkluderats i denna litteraturstudie framkom det att dessa individuella behov kan ha negativ påverkan på föräldrarna. Autismspektrumtillstånd är en neuropsykiatrisk funktionsnedsättning där personen har ett annorlunda sätt att ta in, bearbeta och tolka information.

Background: Because of the high unhealthy rates among women in the com-mune a project to reduce it have begun. For this reason we have been given the mission from the commune of Sotenäs to study the character of these women's health. Objective: To study the health among permanent employed women in the commune of Sotenäs. Method: Quantitative method. The data have been collected through question-naire survey.

This is a qualitative interview study of the importance of the non-verbal communication related to the reference situation at public libraries. The experiences of both librarians and users of the reference service have been explored with regards to non-verbal communication. Eight interviews have been carried out. The results reveal that the users and librarians consider that it is important that the librarian find eye contact as well as give affirmation through nodding and smiling. To demonstrate interest and involvement in the questions through attentive listening is also of great value.

Background:Life-cycle costing (LCC) is an investment calculation that takes intoaccount operating costs throughout the investee lifecycle. LCC calculations are mainly usedto evaluate investments that have no revenue side. Attempts to apply the LCC calculations forbuilding-related investments have occurred since the 1980s. Despite the advantages ofusing LCC calculations, use has not passed through in full. The main obstacles have beenidentified as a lack of relevant input data, and insufficient experience of workingwith LCC calculations.

Title: Has youth participation in organized extracurricular activities and future expectation relevance for antisocial behavior? Zetterberg, E. (2015). Has youth participation in organized extracurricular activities and future expectation relevance for antisocial behavior? Bachelor thesis in Public Health science.