Vectors based on lentivirus backbones have revolutionized our ability to transfer genesinto many cell types. Lentiviral vectors integrate into the chromatin of target cells and do not transfer any viral genes causing vector replication. Both of these features arecommonly used in gene therapy and have been used clinically in individuals sufferingfrom cancer, infections and genetic diseases. It has been discovered that T-cells can be genetically modified to be used as effective weapons against cancer: therefore virus mustbe produced to deliver the gene of interest into the T-cells. In this project, lentiviralvectors have been produced to transfer the gene coding for a chimeric antigen receptor(CAR) which is directed to CD19 on B-cells.

This report deals with the theory and empirical evidence of how knowledge generated within a project is to be captured and shared with other projects and the surrounding organization, after the end of a project. A number of authors have highlighted knowledge management within a company as a key component in building a unique competitive advantage and knowledge should therefore be considered a very important resource within companies. The difficulties of ensuring that knowledge generated within a project can benefit other projects are many. The nature of the project form has been highlighted as one of the biggest problems, due to the fact that budget and time requirements often restrict the propensity to work with knowledge transfer. Other difficulties that this report highlights are in particular the lack of a knowledge sharing culture within the organizations, as well as human cognitive and psychological limitations and lack of tools design for knowledge transfer.

The society strives for sustainable development, in the construction industry it is expressed through sustainable building. Energy and LCC analyzes increases the ability to make conscious decisions in the process. A problem in the construction industry is that energy and LCC analysis is not used to the desired extent, as they are perceived as complicated and time consuming. The report aims to achieve a more sustainable building through increased use of energy and LCC analyzes.The goal is to show how BIM can be used to improve the efficiency of the energy and LCC analyzes.The study was conducted with a literature review and a case study to answer which information that is required in a BIM model to perform energy and LCC analyzes. The study also shows which software can be used in BIM based energy and LCC analyzes and how the analyzes can be carried out efficiently.The result shows that effective analyzes may be performed if the BIM-model contains the relevant information for making analyzes.

Recording and analyses of superovulation results and fertility records at the nucleus herd Viken The development of different reproductive technologies aim at increasing the number of progeny per individual parent, and in that improving the possibility of genetic progress. One technique, embryo transfer, have facilitated genetic dissemination and shortened the generation interval also in females. Nötcenter Viken is a company that run embryo collection and embryo transfer in the breeds Swedish Red and Swedish Holstein. It is located outside Falköping. Information is continuously gathered about cows tested at the nucleus herd.

Digital preservation is a relatively new subject to Swedish archives. Alhough computers have been used for a long time, preservation has been made on paper and stored on shelves. These days a lot of cities in Sweden have investigated how to best secure the digital information for the future through electronic archiving, e-archives. One option is to hand in the information as soon as possible, but to let the producer keep the information ownership yet some time. The idea is to let the producers of the information answer questions and hand out material, since they are more competent on their field.

Companies that sell digital products such as software and movies transfer large amounts of data to its customers. In order to send this amount of data using FTP or HTTP and still maintain a high speed transfer rate it is required that the company have a large number of servers and a huge bandwidth. Servers and bandwidth costs money which means they have great costs on the distribution of their products. In order to reduce distribution costs, P2P technology can be used and the most powerful technology to transmit popular files is called BitTorrent.BitTorrent requires users to share their bandwidth. Nowadays, BitTorrent is frequently used to transfer products that are free of charge; one example is the Linux distribution Ubuntu.

Following the accident at the nuclear power plant in Chernobyl in 1986, great volumes of137Cs were distributed over large parts of the former Soviet Union and Europe. Over Scotland,radiocaesium was deposited as wet deposition. Due to the relatively long physical half-life of30 years, there are still measurable activity concentrations in the natural environment. Thisstudy was made on two organic soils, Knockandy Hill and Rora Moss, situated in the easternpart of the central highlands of Scotland. At these two sites, studies on migration and transferbetween soil and plants were conducted.

In recent years cognitive training in order to improve cognitive abilities have becomeincreasingly popular and a lot of research has been conducted within this field. The natural agingprocess has a negative effect on many of our cognitive abilities and this relationship also has a strongconnection with hearing loss. Elderly with hearing loss is therefore a group that could benefit fromcognitive training. Objective: The purpose of this study was to investigate different types of cognitivetraining directed towards working memory in older adults and to examine the results observedregarding efficacy of this type of training and its transfer effect. Method: A literature reviewconsisting of 17 scientific articles published between 2005-2014.

The purpose of this thesis for Sapa Heat Transfer is to examine a furnace in which aluminium is pre-heated before hot rolling. The project is modeled in a computer environment in which the air flow in the furnace and the heat transfer to the aluminium solids are included. The computer environment and its governing equations, as well as boundary conditions and generalizations, are presented and explained.The simulations are based on two models. The first model has an asymmetric solid placement, which is how it looks in today's ovens. It is validated against collected data.

The purpose of this thesis was to examine if users of digital music games may acquire skills from the games that may be of use in learning to play a real instrument, that is a non-digitally simulated instrument like an acoustic piano. We have used Gee?s theory regarding a possible interconnection between different semiotic domains, and how this connection may enable a transfer of skills between related domains. In this thesis we examine possible skill transfer between the domains ?digital games? and ?non-digital instruments?. To examine our question formulation we chose to conduct a pilot study from which we collected both quantitative and qualitative data.

At the Department of Technology and Built environment at the University of Gävle there was an interest to study GNU Radio, which is an "open source radio project. The project is based on that most of the radio signal processing is made in an ordinary PC. The idea behind this degree project was that in a laptop there are several radio transmitters/receivers that takes space, generates heat and transmit in varied frequency band etcetera. All these radio transmitters/receivers could be replaced with a Software Defined Radio system. It means that one common, general radio hardware is used to different communications such as: WLAN, Bluetooth, GPRS, 3G etcetera. The waveform is generated in the software, which makes the system very flexible.

The purpose of this thesis was to examine if users of digital music games may acquire skills from the games that may be of use in learning to play a real instrument, that is a non-digitally simulated instrument like an acoustic piano. We have used Gee?s theory regarding a possible interconnection between different semiotic domains, and how this connection may enable a transfer of skills between related domains. In this thesis we examine possible skill transfer between the domains ?digital games? and ?non-digital instruments?. To examine our question formulation we chose to conduct a pilot study from which we collected both quantitative and qualitative data.

The society strives for sustainable development, in the construction industry it is expressed through sustainable building. Energy and LCC analyzes increases the ability to make conscious decisions in the process. A problem in the construction industry is that energy and LCC analysis is not used to the desired extent, as they are perceived as complicated and time consuming. The report aims to achieve a more sustainable building through increased use of energy and LCC analyzes.The goal is to show how BIM can be used to improve the efficiency of the energy and LCC analyzes.The study was conducted with a literature review and a case study to answer which information that is required in a BIM model to perform energy and LCC analyzes. The study also shows which software can be used in BIM based energy and LCC analyzes and how the analyzes can be carried out efficiently.The result shows that effective analyzes may be performed if the BIM-model contains the relevant information for making analyzes.

Titel: Transfer of training ? en studie av överföringsprocessen av säljträning med avseende på motivation och målsättning.Författare: Therése Eriksson & Lovisa SöderlundUppsatsnivå: Examensarbete i Företagsekonomi för kandidatexamen, 180 hp VT-14Handledare: Lars-Johan Åge, Jonas Molin & Jens Eklinder FrickDatum: 2014-05Syfte: Vi vill undersöka om och hur säljares målsättningar påverkar säljare att ta till sig säljträning och omsätta den i praktiken.Metod: Med syftet som utgångspunkt har en kvalitativ metod använts i undersökningen där empirisk data erhölls genom att utföra 12 semi-strukturerade intervjuer med respondenter från fem telefoni- och elektronikföretag i Gävle. En strukturerad, abduktiv analysmetod som gör det möjligt att analysera kvalitativ data användes för att analysera och identifiera mönster i materialet. Resultat: Studien visar att motivation är av stor betydelse när det kommer till säljträning och huruvida säljare väljer att använda sig av träningen. Det som motiverar säljare att använda sig av säljträning är huruvida det kommer leda till ett ökat försäljningsresultat. Vi ser också att motivationen till överföringen är beroende av säljarnas personliga mål eftersom målen har med deras egna värderingar att göra och det är dessa mål som främst driver säljarna.

Titel: e-Commerce and Relationships ? Customer Relationship Management This bachelor thesis is brought together to analyze the transformation from traditional marketing to Customer Relationship Management. The development in the technology world has made the marketing focus shift from products and their functionality to customers and value creation. Because of the tougher competition that developed from new channels of communication, corporations had to generate new sources of value for their customers in order to establish lasting relationships with them. Therefore we found it interesting to investigate how companies within the e-commerce business handle the transition towards customer relationship management.