SUMMARYThis work consists of a review of the medical records of 142 horses that visited the Equine dermatology clinic, at the University Animal Hospital, UDS, at Ultuna, Uppsala, Sweden, between January 2007 and June 2010. The study answers certain main questions like clinical signs responsible for the visit, the most common diagnoses, their diagnostic procedures, treatment modalities and finally, the outcome of treatment.Among 50 diagnoses, four were predominant followed by additional 46 diagnoses, each presenting by few or, in many cases, only one horse. The most common dermatological problem diagnosed was Equine Sarcoid representing 18,3 % of the cases (26/142), which probably reflects the initiation of a Sarcoid treatment-trial in 2007, that resulted in an accumulation of sarcoid horses in the clinic .The second most common diagnosis was Atopy 12 % (17/142) followed by Allergy with skin affection 9,2 % (13/142) and Acute superficial pyodermia 4,9 % (7/142). If the horses were divided into diagnostic groups, the majority (34,5 %) belonged to HA5 group, (Immunological skin diseases), followed by group HA4, (Infectious and inflammatory conditions of the skin) (22,5 %) and HA6, (Neoplasia) (21,8 %). Traumatic skin injuries represented only 2,1 % of the cases, compared to 80 % of horses in the Agria insurance statistics for veterinary care.The most common clinical sign and reasons for veterinary consultation was pruritus (35,9 %), suspected sarcoids (17,6 %), alopecia (12,7 %), nodules (12 %), seborrea, scaling and crusts (9,2 %) and excoriations (5,6 %), respectively, followed by a scattered number of more uncommon symtoms.The diagnostic methods most frequently applied were cytology and biopsy, used in 41,5 % and 36,6 % of the cases, respectively.

The purpose of this study was to describe how adolescents aged 12-18 years with inflammatory bowel disease experience their illness and what coping strategies they use to manage their illness and improve their wellbeing. The method used was a descriptive literature study, and the result of the study included 15 scientific articles. Our results showed that IBD affected the adolescent?s everyday life and social life with friends, family and activities. The adolescents also reported that they experienced a feeling of vulnerability, altered body image and that they saw themselves as different from healthy subjects.

This study was performed in order to evaluate if the method of collecting uterine secretion by the tampon-method is representative for use in studies of uterine secretions in mares. Uterine secretion collected by tampon in six mares was compared with secretion collected by aspiration, regarded to be a native sample, at the Institution of Obstetrics and Gynaecology, SLU, Uppsala. Proteinanalysis was made at the Department of Farmaceutic Bioscience, toxicological unit, Uppsala University. Cytological smears and ultrasonography was used to assess if the tampon had caused an inflammatoric reaction that could influence the protein content of the samples. The results suggest that the tampon and aspirat method do not differ when it comes to proteinconcentration, but the distribution of proteins differ between these different collection methods. This difference could not likely be explained by means of proteins due to an inflammatory reaction from the tampon, since neither the cytological nor the ultrasonographical examination gave any indications of inflammation.

Inflammatory Bowel Disease hos häst är ett allvarligt tillstånd som kan ta olika uttryck, gemensamt är dock en inflammation i tarmen med svåra skador som följd. Olika etiologier har föreslagits, men det är troligt att immunsystemet har en avgörande roll i sjukdomsutvecklingen. I den normala tarmen utvecklar immunförsvaret tolerans mot kommensal mikroflora. En viktig pusselbit i den utvecklingen är aktiveringen av naiva T-celler till regulatoriska T-celler som dämpar immunförsvaret. De regulatoriska T-cellerna verkar suppressivt på T-hjälparceller via cytokiner och cellcellkontakt samt kan aktiveras centralt i thymus eller perifert, exempelvis i tarmen.

Hästägaren är den som har det yttersta ansvaret för hästens välbefinnande. En viktig uppgift är att se till att hästen får ett väl anpassat foder för att undvika foderrelaterade sjukdomar. Det finns stora skillnader mellan den domesticerade och den vilda hästens foderstat. Den största och mest markanta skillnaden är att den domesticerade hästens foderstat till stor del består av stärkelse från spannmål då detta ingår i kraftfoder. Fång är också en foderrelaterad sjukdom där de mest framträdande symtomen är smärta i hovarna.

In this study, 29 calves were dehorned by heat cauterisation at the age of 1 to 8 weeks. Before the procedure, the calves were given local anaesthetic but were not sedated. In connection with the dehorning, 14 calves were given the non-steroidal anti-inflammatory drug (NSAID) meloxicam and 15 calves were given placebo. During the following three days behavioural studies were performed to investigate if the different treatments had any effect on the calves´ postoperative behaviour. Head shakes, head rubs, kicks and ear flicks were studied, as earlier studies have shown that an increase in these behavioural patterns suggests postoperative pain.

The purpose of this project was to investigate if retention of polar compounds that are given to treat tuberculosis, diabetes, inflammatory bowel disease and childhood leukemia could be obtained with HILIC separation. By varying different parameters for different types of columns the compounds were analyzed with the aim of finding guidelines for future method optimizations. To perform these analyzes three different columns were tested ? ZIC-HILIC (silica-based with zwitterions), ZIC-pHILIC (polymer-based with zwitterions) and XBridge Amide (amide functions). The results were evaluated with selected quality measures.

Träningsinducerad lungblödning, Exercise-induced pulmonary hemorrhage (EIPH), är ett stort problem hos travare och galoppörer i hela världen. Det får anses klarlagt att mekanismen bakom EIPH är så kallad stress-failure, utmattningsskador, i blod-gasbarriären vilket beror på att hästarna har en respiration och cirkulation som ger extrema påfrestningar på denna sköra struktur. En bidragande faktor till stress-failure tycks kunna vara att hypertension i lungvenerna leder till att dessa remodelleras och förtjockas, vilket i sin tur leder till ännu högre tryck i lungkapillärerna. Den här litteraturstudien handlar om hur inflammation i lungorna kan ge upphov till EIPH. Inflammation finns med i problematiken runt EIPH både som en bakomliggande faktor och som ett resultat av blödningen.

Thoroughbred racehorses have suffered from exercise-induced haemorrhage for over 300 years. Almost all competing horses develop exercise-induced pulmonary haemorrhage (EIPH) at some point but most horses don?t suffer from reduced competing capacity due to the disease. The cause of the exercise-induced haemorrhage is unknown. The most believed theory today is that EIPH is induced by pulmonary stress failure caused by pressure over 100 mmHg in the pulmonary arteries during exercise.

5-hydroxytryptamin (5-HT) is biochemically derived from Tryptophan. Kynurenic acid and quinolinic acid are also known metabolites of tryptophan. 5-HT is considered to play a role in depression and today selective serotonin reuptake inhibitors (SSRIs) are used for treatment of depression. 5-HT may also play a role in pain perception. The aim of this study was to investigate whether a supplement of tryptophan may affect conditions such as depression and/or pain.

Pyometra, chronic purulent metritis in metoestrus, is a common disease in intact bitches. About 25% of all bitches in Sweden have contracted the disease before ten years of age. Clinical signs of the disease are varied, and the course may be either slow or acute. The diagnosis is most commonly made by radiographical or ultrasonographical examination of the abdomen in combination with blood biochemical and hematological analyses. The safest and most efficient treatment of pyometra is surgical ovariohysterectomy.There is room for improvement of both diagnostic tools and possible prognostic indicators for pyometra.Mast cells are large leucocytes, with granule that contain inflammatory mediators.

Rheumatoid arthritis is an autoimmune disease, where joints are attacked by the own immune system, leading to chronic inflammation and destruction of bone and cartilage. Inflammation is a complex process, controlled by many different substances. One of them is adenosine, which has anti-inflammatory properties. In this project, three polymorphisms in different genes, involved in synthesis and signaling of adenosine, were genotyped for 188 patients with RA and 362 controls without RA. The results shows that for the polymorphism in A2a, a gene coding for an adenosine receptor, there was no significant difference in genotype distribution between the groups.

Lower urinary tract diseases are a common problem in cats all over the world. The symptoms are for example dysuria, pollakuria, stranguria, periuria and hematuria. In approximately two thirds of these cats the underlying cause is not known and the disease is therefore called feline idiopathic cystitis (FIC). We need to know more about the disease to get a consistently effective treatment and prevention. A retrospective study was performed in 50 cats with symptoms of FIC and where other causes of inflammation were ruled out. Data like breed, age, sex, body weight, feeding, therapy and therapeutic results were collected, also if it was an indoor or outdoor cat, duration of the symptoms, if there was any stress and if the cat was living with another cat.

Bakgrund: Inflammatoriska tarmsjukdomar innefattar Crohns sjukdom och ulcerös kolit. De senaste åren har en ökning av de kroniska sjukdomarna skett bland annat i Sverige. Sjukdomarna går i skov och drabbar olika lager av tarmens slemhinna. För att hjälpa personerna att uppleva hälsa, trots kronisk sjukdom, bör sjuksköterskan känna till hur de upplever det att leva med sjukdomen. Syfte: Syftet med litteraturstudien var att beskriva personers upplevelse av att leva med en inflammatorisk tarmsjukdom.

Traumatic arthritis is a common cause of lameness in horses. One of different treatment alternatives of arthritis, is intra-articular injection with hyaluronan. As knowledge about pathophysiology of arthritis and function of hyaluronan is increasing, understanding grows about the mechanism of hyaluronan action in joints. Hyaluronan has, in addition to effects on viscosity, anti-inflammatory and analgesic effects. Extensive research and scientific studies have been made on exogenous hyaluronan.