Inflammatory airway disease (IAD) is a respiratory disorder that most commonly affects young horses performing at a high level. The clinical signs are often mild but the disorder can cause a marked decrease in performance to a point where the horse has to be taken of training and competing. The aetiology underlying IAD is not yet fully understood. One current theory is that a type I-hypersensitivity reaction due to allergens in the environment is the cause in some horses. The most reliable diagnostic method is a bronchoalveolar lavage (BAL) since it reflects the inflammatory status in the most distal parts of the lungs, which are affected in IAD.

Traditionellt sett har gurkmeja använts för medicinskt bruk i många olika länder och kulturer för en rad olika besvär på både djur och människor. Användningen idag är framför allt som kosttillskott, som del i digestionsbefrämjande medel och för att lindra ledbesvär. I Sverige idag är Galexir det enda godkända traditionellt växtbaserade läkemedlet innehållande gurkmeja. Gurkmeja har visat sig ha låg biotillgänglighet, men höga koncentrationer uppnås lokalt i tarmen vilket skulle kunna göra mag-tarmbesvär till en bra indikation för användandet av gurkmeja. Den här litteraturstudien syftar till att ta reda på om gurkmeja kan ha potential att användas på hundar med gastrointestinala besvär. Sjukdomar såsom gastrit, magsår, enterit, kolit, Inflammatory bowel syndrome (IBS) och Inflammatory bowel disease (IBD) kan ses hos hund.

Joint injury (inflammation) or osteoarthritis is the most common cause of poor performance in the athletic horse. Osteoarthritis is the ensuing degeneration of joint cartilage due to inflammation/injury. The single most important factor in the inflammation cascade of joint injuries is interleukin-1 (IL-1). Until recently, these injuries have been treated with products like hyaluronic acid, cortisone and polysulphated glycosaminoglycans (PSGAG). Several studies have not been able to demonstrate a significant difference in the clinical improvement of joint injuries treated with hyaluronic acid or PSGAG and saline.

In this study, cortisol in saliva and pain related behaviours in calves were used as markers of distress when comparing two different dehorning methods; scoop or cautery. We also investigated the effect of a non steroidal anti-inflammatory drug (NSAID), meloxikam, on postoperative distress after dehorning with either dehorning scoop or cautery iron. Twenty calves were dehorned on one randomly chosen side by scoop method and on the other side by cautery. Five months later, the effect on horn growth was investigated. Horn production was observed in seven of the calves.

It is a well known fact today that suffering due to skin disorders is one of the most common causes to veterinary calls. For the Doberman breed included in the group of working dogs, the frequency and distribution of the different skinrelated diagnoses that causes visits to the veterinary clinics remains undocumented. The purpose of this study was to evaluate the frequency of skinrelated problems causing veterinary visits of Doberman at four different veterinaryclinics in Sweden retrospectively, and compare these results with dogs in general and three other working dog breeds with the help of information collected from Agria - a Swedish animal insurance company. The total amount of veterinary calls that were registered at the clinics in question during the time of the study was 2460 visits. From these, 658 visits were due to skinrelated disorders, which amount to 27%. The most frequent cause to skinsuffering was injury caused by trauma, 15,7% of the Dobermans that were included in the study were affected, the second most frequent cause was inflammatory and infectious skin problems with 12,3% followed by neoplastic changes in the skin with 7% of the Dobermans affected.

Atopic dermatitis (AD) is a complex, often lifelong allergic disease affecting around 10 % of both dogs and humans. The hallmark symptom is severe pruritus, causing a lowered quality of life. Mast cells (MCs) are known to play an important part of the immunopathogenesis, promoting a faulty T helper cell type 2 (Th-2) response which follows by a production of specific immunoglobulin E (IgE) antibodies towards environmental allergens (Ag). To further investigate the role of MCs and its mediators in the progression of AD, a low-calcemic vitamin D3 analog (MC903) was used to induce AD-like symptoms locally on the ears of two different knock-out (KO) mouse strains. The first strain was Wsh-/- mice deficient in MCs.

The veterinary handling of wildlife, both in zoos and in the wild, commonly requires that the patients need to be captured and immobilized for examination or treatment. This emphasises the need for quick, on-site, laboratory equipment, in order to minimize the analysis time and thus the stress for the animal and also in order to increase the possibility of starting relevant treatment early on. The aim of this pilot study was to determine whether Serum Amyloid A (SAA) could be a measured in blood samples from bottlenose dolphins (Tursiops truncatus), Asian elephants (Elephas maximus) and South American tapirs (Tapirus terrestris). SAA rises to its maximum about 24 hours after the introduction of an inflammatory agent in companion animals. This also correlates with the estimated time it takes for animals at Kolmården Wildlife Park to be examined and having blood samples collected after being observed as sick. The study also evaluated whether the Eurolyser SOLO, using a turbidometric immunoassay (TIA) developed for human diagnostics, could be used for such analysis. This pilot study was a retrospective analysis of SAA in convenience sampled frozen serum, collected from dolphins, elephants and tapirs.

Denna litteraturstudie undersöker möjliga orsaker till att hästar drabbas av magsår. Magsår är ett vanligt förekommande problem hos hästar, med hög prevalens i många studier, framför allt är varmblodstravare och fullblodsgaloppörer drabbade. Ulcerationer bildas främst i den kutana slemhinnan i magsäcken. Magsår uppstår på grund av höga syranivåer och nedsatt skyddsförmåga i mucosa vilket skapar en obalans med sänkt pH och vävnadsskada som följd. Ofta är tillståndet subkliniskt, men kliniska symptom som till exempel kolik, viktnedgång, dålig aptit och diarré kan förekomma.

Denna uppsats tittar närmare på fyra verk av Jenny Holzer. Hennes konstnärskap jämförs även med Guerilla Girls. Huvudmetoden utgörs av bildanalyser och jag presenterar också tolkningsmöjligheter utifrån ett genusperspektiv. Utöver detta har jag med en konsthistoriografisk undersökning fått fram hur den generella bilden av Holzer ser ut..

Sahlgrenska Academy at University of Gothenburg Department of Internal Medicine and Clinical NutritionAbstractTitle: Can probiotics prevent atopic dermatitis in children with high risk?Author: Laura Pienihäkkinen and Max OlinSupervisor: Heléne Bertéus ForslundExaminer: Anna WinkvistProgramme: Dietician study programme, 180/240 ECTSType of paper: Examination paper, 15 hpDate: May 22, 2012Background Allergic disease is today common, this including atopic dermatitis, which is the most common inflammatory skin disease in the world. Heredity has been shown to play a major role in the development of this disease. It is therefore of high interest for both the individual and society to find effective methods for preventing atopic dermatitis in individuals with high risk profile. Probiotics are beneficial for the bacterial profile in the intestine and it is therefore of interest to study if they through their anti-inflammatory effect could prevent atopic dermatitis.Objective The aim was to study whether administration of probiotics to the mother and the child (directly or via breast milk) could prevent atopic dermatitis in children with high risk profile (at least one first degree relative with a diagnosed allergic disease).Search strategy A systematic literature search was done in databases PubMed and Scopus with search terms maternal, prenatal, probiotics, allergy, atopic dermatitis, prevention, and children.Selection criteria Randomized, controlled human studies and original articles in English were included.

Inflammatory bowel disease (IBD) är ett samlingsnamn för en grupp inflammatoriska tarmsjukdomar och en av de vanligaste orsakerna till kroniska mag-tarmsymtom hos hund. Orsakerna till IBD är inte helt fastställda men tarmslemhinnans immunförsvar, bakterieflora, genetiska faktorer och miljöfaktorer anses vara centrala för tillståndet. En av de mest utbredda uppfattningarna är att sjukdomen uppkommer som ett resultat av bristande immunologisk tolerans som gör att immunförsvaret felaktigt går till attack mot harmlösa antigen. Syftet med den här litteraturstudien var att undersöka vilken roll Pattern recognition receptors (PRRs) har i IBD, hur tarmbarriären påverkar risken för sjukdomen, vilka förändringar av tarmfloran som setts hos IBD-hundar och hur floran påverkar sjukdomsuppkomst. Litteraturen menar att en defekt tarmbarriär är en av de nyckelfaktorer som hör ihop med IBD. Ökad permeabilitet i tarmen kan öka exponeringen, och därmed interaktion, mellan antigen och immunförsvar vilket inducerar inflammation. Oavsett om en defekt tarmbarriär uppkommer som en effekt av sjukdomen eller om det är en direkt orsak till IBD så är det troligen viktigt för att det ska bli kroniskt.

Syfte: Syftet med studien var att beskriva unga människors upplevelser av att leva med en inflammatorisk tarmsjukdom (IBD), samt att beskriva hur sjukdomen påverkar livskvaliteten. Vidare var syftet att beskriva artiklarnas kvalitet utifrån den metodologiska aspekten urval.Metod: Beskrivande litteraturstudie baserad på 14 vetenskapliga artiklar, som söktes i databaserna Cinahl och PubMed via Högskolan i Gävle. Sökorden som användes var: Inflammatory bowel disease, Quality of life, Chronic disease, Experience och Adolescents. Sökningarna var begränsade inom publiceringsåren 2009 - 2013.Huvudresultat: De unga människorna upplevde många olika besvärande symtom som sågs som ett hinder till ett ?normalt? liv, och symtomen visade sig ha ett samband med ungdomarnas sömnkvalitet samt ångest och depression.

Thermography is the assesment of the surface temperature of the horses body and it falls into the categori of physiological imaging. Thermography allows us to portray inflammation and changes in sympathetic tone in a graphical manner. The purpose of this study was to review thermography in equine medicine and to evaluate thermography as an aid in the diagnosis of lamness in horses. Thermography has been helpful to identyfy sprains, stress fractures, shin splints and soft tissue, tendon, ligamentous and nerv injuries and to monitor healing processes during rehabilitation. Routine thermography may reveal inflammatory responses prior to clinical signs. In present study thermograpy gave especially valuabel information in two cases. In one horse reduced blood flow in a. saphena due to a thrombosis were visualised and in the other horse bilateral thoracolumbal radiculopati was diagnosed.

Sahlgrenska Academyat University of GothenburgDepartment of internal medicine and clinical nutritionAbstractTitle: Does omega-3 mitigate skin symptoms in psoriatic patients? ? A systematic review about the effects of supplementationAuthor: Anita Borgmästars and Sara LinderSupervisor: Mette AxelsenExaminer: Anna WinkvistProgramme: Dietician study programme, 180/240 ECTSType of paper: Examination paper, 15 hpDate: May 22, 2012Background: Psoriasis is an inflammatory skin disease with high prevalency. Its treatment is time-consuming and associated with many side effects. Therefore alternative forms of treatment, among them omega-3 supplementation, have been investigated. Omega-3 is a family of polyunsaturated fatty acids whose metabolites participate in the regulation of inflammatory reactions in tissues and may therefore have a positive effect on skin symptoms in patients with psoriasis.Objective: To determine if omega-3 supplementation has a beneficial effect on skin symptoms in psoriasis compared to omega-6 supplementation by rating the evidence quality in available studies.Search strategy: The literature search was conducted in the databases PubMed, Scopus and Amed.

Diseases associated with monocytosis in Swedish dogs - a retrospective study. The purpuse of this retrospective study is to determine which diseases are associated with pronounced monocytosis in Swedish dogs. Records of 153 dogs with monocytosis were evaluated. The most common cause was infectious diseases (49%) of which pyometra was seen in 23% of the cases, cystitis and fever of unknown origin each in 13% and gastroenteritis in 12%. Cortison treatment was the second most common cause with 29%. A sixth of the dogs had non inflammatory diseases such as neoplasia, renal- and heartfailure.