Alternative splicing is a process that partly rejects the common definition of a gene ? that one gene codes for one specific protein. By variable combination of coding regions (exons) and exclusion of non-coding regions (introns), formation of several different mRNA-transcripts, and consequently several different proteins, can derive from the same gene. Alternative splicing is an important condition for the development of complex life forms, but it is also a highly sensitive process and inaccurate splicing is the cause of approximately 15 % of mutations that cause genetic diseases. This article presents four genes, BRCA1, BRCA2, ER? and ER?, and inaccurate splicing of these genes increases the risk of developing cancer, particularly breast cancer and ovarian cancer.

Hyperthyroidism and chronic kidney failure (CKD) are common diseases in older cats. It can be difficult to evaluate kidney function in cats suffering from both conditions simultaneously. In the daily clinic serum creatinine is the analysis of choice when evaluating kidney function and secondary glomerular filtration rate (GFR). This marker does not, however, detect kidney damage until about 75 % of the function is lost. There are several other techniques available when investigating GFR but none are readily available for the small clinic.

The purpose of the study was based on scientific literature to describe the quality of life of persons who have undergone a total hip replacement. The method was a descriptive literature review. The results showed that pain was the most obvious change after surgery. Mild pain before surgery was strongly associated with mild pain after surgery. But despite less pain were experienced early, it took 1 year to achieve the full benefits of improved physical function.

Cycling is one of the most sustainable transport modes available and it is widely promoted inmany urban areas. The health benefits from cycling has shown to be substantial, includingdecreased risks of diseases related to overweight and enhancing brain capacity. However, inurban areas cyclists can temporaly be exposed to high levels of air pollution, resulting inhealth risks as opposed to health benefits.The objective of this thesis is to develop a rasterbased test model in GIS that estimates theinhaled dose of air pollution for cyclists based on relative particle concentration in differenttransportation micro-environments. The method used is a least-cost path approach,calculating three different routes; shortest, fastest and least dose for four different trips withinSödermalm, Stockholm.The results show that the inhaled particle dose can be greatly reduced, 39% - 58% for three ofthe routes, by choosing the least dose route. One of the most interesting findings is thesubstantial increase of dose when high levels of particles are combined with uphill cycling.The conclusion for the thesis is that a raster-GIS model can be very useful for estimating doseof different air pollution particles and chemicals along cycling routes.

In modern dairy production, the newborn calf generally is separated from its mother and put in a single pen for some time before it is introduced to group housing. Group housing is becoming more and more common because it saves the farmer a lot of valuable time. Even thought group housing has a lot of benefits it is often associated with a higher morbidity and mortality in the young calves. Therefore, knowing the optimal way to use the group pen lies in many farmers? interests and the importance of different factors such as the optimal age of introduction is important to evaluate. The aim of this study was to investigate the effect of age at introduction to group housing on the health of the calves in the group pen.

The field rehabilitation in veterinary medicine has expanded over the past ten years. Animalswith disorders in the musculoskeletal system are often treated. The methods used lacksufficient scientific documentation; however claim to affect the animal's function in a positiveway. In order to investigate the efficacy of different rehabilitation modalities, it is important touse validated evaluation tolls. Therefore, a literature study on pain, pain-scales and functionaltest was performed together a pilot study on a functional test.The aim of the present pilot-study was to investigate a functional test, "Bioarth functionalevaluation scale", used in veterinary medicine.

Canine otitis externa is a common reason for a visit to the vet. Predisposing factors often complicate treatment and may result in a chronic disease progression. All otic preparation for topical use in Fass Vet contain antibiotics, corticosteroids and a fungicide. Sixty cerumen samples from dogs with external otitis, sent to the Department of Bacteriology at SVA, were categorised according to their profile of isolated microorganisms. Staphylococcus intermedius alone or together with Malassezia pachydermatis were the most common organisms found. Fifteen percent of the samples contained M.

Septic tenosynovitis involving the digital sheath is a relatively common problem in the horse and the prognosis has been considered as poor. However, there are only few studies confirming this. The purpose of this study is to increase the knowledge about the prognosis for septic tenosynovitis in the digital sheath. The literature indicates that half or a bit more than half of the treated horses will return to previous use. The recommended treatment is debridement of the wound, lavage and sometimes application of drains and broadspectrum antibiotics. The prognosis is considered as worse when the infection is established.

The aim was to study the factors that contributed to the prescription of physical activity on prescription (PaP) by the professions in primary healthcare. A qualitative method was used in the study. The sample consisted of six participants; two doctors, two physiotherapists and two district nurses in primary healthcare in Uppsala County. The data were collected with semi-structured interviews and were analyzed with a thematic approach. The results show a great variety in which type of patient that receive PaP, however people with lifestyle diseases such as diabetes, hypertension and obesity are often more represented.

Over a long time psychology was focusing on human frailties and mental diseases. In 1998, positive psychology was introduced - the scientific study of strengths, well-being and optimal functioning. Theory and research in the area has identified 24 character strengths, in which each individual owns and celebrates a number of top strengths, signature strengths. These strengths have been shown to be important in achieving happiness and well-being. The purpose of this study was to investigate the relationship between character strength and psychological well-being, job satisfaction, harmonious- and obsessive passion and stress.

Background: Mastitis in dairy cattle is a common ailment worldwide. A cause of mastitis can be bacteria such as Escherichia coli. Mastitis is not a deadly ailment and sometimes the dairy cows show no symptoms but if certain virulence genes are present in the bacteria that cause the mastitis, the bacteria can be transmitted to humans and cause severe diseases. The potential presence of enterohemorrhagic Escherichia coli (EHEC) in particular would be a major concern for human health.Aim: The aim for this study was to analyze the presence of virulence genes known to be present in E.coli strains isolated from dairy cows with mastitis in Sweden.Method: A Qiagen BIO ROBOT EZ1 was used to purify DNA from 90 bacterial cultures. A panel of virulence genes were amplified and biotinylated from the purified DNA by PCR and an E.coli based DNA microarray was used to detect presumed virulence genes in E.coli.Result: There were no samples that had all the genes traditionally used to classify E.coli as EHEC or potential EHEC.

Bovine viral diarrhoea virus (BVDV) is the causative agent of a complex of disease syndromes in cattle with high economical and welfare impacts. BVDV occurs as two biotypes; cytopathic (BVDVcp) and noncytopathic (BVDVncp) determined by differential effects on cultured cells and can also be divided into two genotypes (BVDV1 and BVDV2) on the basis of genomic diversity. The interaction between BVDV and the host?s immune system is regarded a key aspect in the sequel of BVDV infection. Infection with BVDV normally causes an acute transient infection, with mild to subclinical signs, but occasionally results in severe and even fatal disease.

Organic animal husbandry has received a lot of criticism lately. The aim of this literature review was to examine if the rules and principles of organic pig farming give better or worse welfare in comparison to the conventional systems in Sweden. Health, physiology and behaviour have been used as indicators of welfare in this study. This is due to the importance of using more than one indicator in welfare assessments. Studies have shown that organic pigs have more remarks on joints when slaughtered, but these remarks can be reduced by vaccination against erysipelas.

Today, some kind of laboratory results is required for around 70% of the diagnostics and follow-ups for diseases. In many of the cases the time from sampling to a result is very critical. Therefore the discussion of how to improve this situation has begun. For many analyses serum has been the routine choice for a long time but now it is disputed. After blood collection in a serum tube it is essential to wait 30-60 minutes before centrifugation and analysis of the sample, a long time for someone in an acute state.

Several diseases increase the risk of thrombosis in dogs and cats, often with a fatal outcome. Currently there are no definite treatment guidelines for the use of thrombolytic and thromboprofylactic agents in veterinary medicine. None of these drugs are approved for dogs and cats in Sweden. Medicines aimed for humans have been used tentatively. This literature study is an investigation of what is currently known about the effects and safety of these pharmacological agents when used for dogs and cats.