Conclusion:Medical treatment may have a role in platelet count after transfusion. Since the TACSI platelets passed the quality requirements, and the vast majority of patients platelet count increased after TACSI platelet transfusion, the TACSI platelets will replace the old method to produce platelets at the Uppsala University hospital.  Methods: A new approach that pools 8 buffy coats (TACSI platelets) that were separated into 2 units instead of 4-6 buffy coats pooled to 1 unit was investigated in this study. After the platelets were extracted from the buffy coats their quality was controlled and subsequently the platelet product was evaluated in 96 patients. Results: The results showed that 80 % of the platelet units passed the European quality requirements. Further, the platelet count was increased in most patients that received TACSI platelets. Conclusion: Medical treatment may have a role in platelet count after transfusion.

Apart from recognizing and neutralizing threats, antibodies also have the ability to regulate immune responses against their specific antigen. IgG administered together with erythrocytes is well known to induce >99% suppression. This has been used to prevent haemolytic disease in new-borns since the 1960's, but the mechanism behind it is still not completely understood. The effect on the primary response is well established, but its influence on induction of immunological memory is still heavily debated. In this study adoptive cell transfer of splenocytes to irradiated mice was used to survey the effect IgG has on induction of immunological memory without disturbance from the primary IgG response.

The purpose of this essay is to show how ESN, IKEA and the Ministry for Foreign Affairs (UD) mediated swedishness. This will be done by illustrate and analyse the methods the research fields use to create and spread pictures and message about Sweden, Swedes and Swedish cultures. The essay use the method of represented informants and show three field where the meeting between people and cultures is conspicuously. Hopefully, this essay can be seen as a contribution to the research of identity (identity research). I have chosen to focus on three fields of research, which do not belong to the classic field of research to show how swedishness is mediated..

Celiac disease (CD) is an autoimmune disease, induced by an immune mediated reaction in the small intestine after ingestion of gluten and related prolamines. There is a strong genetic linkage and most important are the genes that encodes for HLA-DQ2 and HLA-DQ8. The European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) has developed new guidelines for investigation of CD in children and adolescents, which include genotyping for HLA-DQ2 and HLA-DQ8. Therefore, the clinical microbiological laboratory in Västmanland wants to introduce a method for analysis of these genes. Microarray is a newly developed method for determination of the alleles HLA-DQA1 and HLA-DQB1 that encodes for the ?- and ?-subunits of the HLA-molecules.

The view on which kind of fiction that should be mediated to the public through the Swedish public library system has since the late 60´s been dominated by what in this Master?s thesis is called: ´the discourse on quality of literary fiction´. The aim of this thesis is to examine to which extent this discourse still plays an active role in the Swedish public library system or if that discourse has been replaced by a more market-led, demand responsive view, where the features of ´quality´ and ´culture´ have been downplayed and replaced by a ´customer?s service view´ on how and why fiction should be mediated to the public. The methodological and theoretical perspective in this thesis is led by the understanding of the discourse analysis in Michel Foucault?s ´The Archaeology of Knowledge´.

Celiac disease (CD) is an autoimmune disease, induced by an immune mediated reaction in the small intestine after ingestion of gluten and related prolamines. There is a strong genetic linkage and most important are the genes that encodes for HLA-DQ2 and HLA-DQ8. The European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) has developed new guidelines for investigation of CD in children and adolescents, which include genotyping for HLA-DQ2 and HLA-DQ8. Therefore, the clinical microbiological laboratory in Västmanland wants to introduce a method for analysis of these genes. Microarray is a newly developed method for determination of the alleles HLA-DQA1 and HLA-DQB1 that encodes for the ?- and ?-subunits of the HLA-molecules.

Tolerance and resistance are two different defence mechanisms within the immune system that differ from each other in many ways: However it is not clear which of the two is the most advantageous in dairy production. Resistance is described as the ability to fight a pathogen in a host. Tolerance is, on the other hand, not aggressive to the pathogen per se, but rather protects the host and its tissues. Furthermore tolerance rather offsets the toxin from, for example, a parasite whilst resistance offsets the parasite itself. Resistance is however disease specific, which means breeding for a large number of diseases is needed in order to make resistance worth the cost for the host.

?Tollarsjuka? is a disease with a suspected immunopathological background seen in Nova Scotia duck tolling retrievers. Pyrexia, lameness, stiffness and joint- or musclepain are typical clinical signs. The purpose of this study is to describe case histories from dogs with a possible evidence of ?tollarsjuka?. 18 private dogs were included in this report. Generalised stiffness, lameness and fatigue were the most frequent manifestations of the disease.

LSV410. Specialarbete, 15 hpHt 2011Handledare: Elisabet Engdahl.

Feline infectious peritonitis (FIP) is a feline viral disease with high mortality. There is no cure or any effective vaccine available today. Many questions are yet to be answered about this disease and the immune response in affected cats. The aim of the study is to evaluate two different techniques for the study of cytokine profiles in cats vaccinated with a vaccine concept against FIPV. More information about the immune response in these cats could give valuable information to better understand the pathogenesis of the disease and the development of an effective vaccine.

Immunmedierad hemolytisk anemi (IMHA) delas i litteraturen upp i en primär och ensekundär form. I denna litteraturstudie kommer fokus att ligga på den primära formen, vilkenär den enda som kan klassas som sant autoimmun, då andra möjliga orsaker till uppkomstenav sjukdomen har uteslutits. Den sekundära formen däremot kan uppstå till följd av flera olikafaktorer såsom infektiösa sjukdomar, andra immunologiska sjukdomar (exempelvis systemisklupus erythematosus), neoplasier, vaccinationer eller mediciner. I båda fallen riktasantikroppar, och ibland även komplementfaktorer, mot cirkulerande erytrocyter varvid enökad nedbrytning av dessa ger upphov till en hemolytisk anemi.Flera olika teorier finns rörande predisponerande faktorer för den primära formen, såsom ras,kön, årstid, ålder samt föregående vaccination. De patologiska fynden varierar beroende påsjukdomens duration, men de mest typiska är ikterus, hepatosplenomegali, färgförändringar injurar och urin, ödematösa lungor och infarkter i desamma samt ökad erytropoes i benmärgen.Sjukdomen är mångfacetterad och mer forskning behövs, bland annat för att fastställa varförvissa individer tycks vara predisponerade, samt för att förbättra behandlingsregimen dåsjukdomen har en hög mortalitet, även vid snabbt insatt behandling..

Our companion animals can, with or without symptoms, carry infectious agents which have a potential to induce diseases in man, so called zoonoses. An immune compromised person has an increased risk of becoming infected by various agents, and thus also has an increased risk to become infected by one?s own companion animals. A study was carried out within the veterinary program at SLU, Sweden, based on a questionnaire answered by 31 physicians, 31 veterinarians and interviews of 30 immune compromised persons in Sweden. The study investigated the following questions: Which zoonoses do physicians and veterinarians consider to be the most important to inform immunecompromised persons about? How are immunecompromised persons being informed by their physicians about the risk of catching zoonoses from their companion animals? How are the owners of zoonosis-infected animals being informed by their veterinarians about zoonoses? Does veterinary medicine and human medicine communicate about zoonoses, in order to take the best care of immunecompromised persons in contact with animals? The results of our study imply that: - Physicians and veterinarians differ about which zoonoses immunecompromised persons should be informed about. - Only oral information is passed to immunecompromised persons and animal owners.

The Bovine respiratory syncytial virus (BRSV) causes bronchiolitis and interstitial pneumonia, predominantly in calves, and is a major cause of bovine respiratory disease worldwide. In humans, BRSV is paralleled by the closely related Human respiratory syncytial virus (HRSV), an important cause of respiratory disease, most severe in infants.The clinical signs and pathology during RSV infection is caused, not only by the direct effects of viral replication, but also by the response of the host immune system. The immunopathology of RSV has long obfuscated our understanding of the disease, and development of effective treatment and vaccines will be very difficult until greater knowledge is gained.One of the components of the immune system that has come into focus in RSV research the last few years, is the Toll-like receptor 4 (TLR4). The TLR4 receptor is well known as the receptor that binds lipopolysaccaride (LPS), and initiates the host response to bacterial infection. Recently, it has been shown that the fusion protein of RSV also interacts with, and up-regulates the expression of, the TLR4 receptor.

Under den diffusa delen av ett projekt i interaktionsdeign fattas beslut om vad som ska skapas. För att strukturera denna process rekommenderar Arvola (2013) ett ramverk för beskrivning av medierad handling. Utöver ett antal informella intervjuer med personer som använt ramverket har inga undersökningar genomförts vars resultat beskriver hur ramverket används i praktiken. Studier som visar hur ramverket bör användas för att ett användbart resultat ska genereras har inte heller gjorts, förrän nu. Genom att under två workshops studera interaktionsdesigners generera designkoncept med stöd av ramverket för medierad handling, har fyra kännetecknande aspekter av hur ett bra designkoncept kan skapas med stöd av ramverket identifierats.

In this essay I have investigated how two families, with children, who have food allergies, experience what support and what treatment they get in preschool for their difficulties. I have interviewed two children and two parents. The study shows that the interviewed parents believe that more knowledge in the community and among staff in preschool, about food allergies, is needed. Parents wish that the staff should write an action plan that describes how to deal with children who have food allergies and that preschool invites parents and children to record results. It is important to consider an inclusive attitude so that children don?t feels excluded.There is some research going on around this subject and researchers agree that the incidence of food allergies in the society is growing, but that it is difficult to be able to present a certain theory why, and what the underlying factors are.