Vectors based on lentivirus backbones have revolutionized our ability to transfer genesinto many cell types. Lentiviral vectors integrate into the chromatin of target cells and do not transfer any viral genes causing vector replication. Both of these features arecommonly used in gene therapy and have been used clinically in individuals sufferingfrom cancer, infections and genetic diseases. It has been discovered that T-cells can be genetically modified to be used as effective weapons against cancer: therefore virus mustbe produced to deliver the gene of interest into the T-cells. In this project, lentiviralvectors have been produced to transfer the gene coding for a chimeric antigen receptor(CAR) which is directed to CD19 on B-cells.

This thesis will guide you through the haunting Business marketing woods of snaring networks and ravel business relations in the dark landscapes of the mighty music publishing creatures. The task at hand (of this thesis) will be to present the secrets that lie beyond with the hopes that you, the daring reader, will gain knowledge and understanding of what these entities do, lurking in the shadows of the woods of business marketing (and of your unknowing mind). How they go head on with their partners in business to thrive on intangible properties and how they find their path through these woods. Explore and discover, if any, commonly found ways in the management of business marketing within the domain of the music publisher. We wish you a pleasant reading!.

Title: How do violin teachers work with music reading? - A qualitative interview study on the phenomena music reading. The purpose of this essay is to investigate how five violin teachers in mixed ages and from different backgrounds teach music reading to their students. The paper is based on semi structured interviews. The result shows that there are as many methods as respondents, but you can find three major methods and that a majority of the teachers thinks that one should teach violin to beginners without reading music.

This study examines the similarities and differences between four guitar teachers in Sweden and the U.S. The aim of the study is to examine how teachers motivate their pedagogical standpoints and to analyze how they experience the frame factors that limit their teaching. Data were collected through interviews with two Swedish teachers and two American teachers. The result shows that the teachers, despite their seemingly different contexts, actually have a lot of common strategies and approaches. Most significant is the tendency to let the students decide some of the content of the lessons.

Abstract The purpose of writing this thesis was to improve methods during requirements engineering phase. Usercentred system engineering has some problem areas, which are examined and verified to create a new guideline for developers. This guideline tends to make requirements engineering more effective and help developers create more concrete requirements. It is not uncommon that system development projects ends up with unsatisfied users or delay in deliveries. The reasons are different kinds of communication problems between users and developers during verification of requirements.

The purpose of this essay is to examine whether the descriptions of Stalin's terror in history textbooks for high school changed from the 1950s until the 2010s. Since previous research shows that textbook content is influenced from different directions and that it dominates in teaching, therefore I want to find out what similarities and differences that exist in the textbooks. The survey is based on a qualitative approach because I want to have a profound picture of the descriptions of Stalin's terror. The results of the survey show that the number of casualties and the descriptions on the famine has changed over time. Furthermore, textbooks also found it difficult to distinguish between terror, politics and ideology.

This paper deals with village history around millstone quarry Eastern Utsjö in Malung, Sweden, in the hope of finding deposits that could date the quarry, in that the quarry in the current situation is dated only by the millstone fragments outside the resort. My purpose was to conduct a discussion on the quarry alone can be dated by deposits outside the resort. I have used FMIS RAÄ:s fornsök and a lot of literature to identify village history. The results showed that it is not possible to date the millstone quarry from village history, but through deposits outside the resort of Malung, which have been found around Mälardalen, Sweden through archaeological excavations, and derived from the millstone quarry Eastern Utsjö, can put an age on the quarry..

This survey tries to find out if and how we can be influenced of extreme low and strong frequencies in the area 0-40 Hz. A group of 52 teachers/musicstudents and non musicstudents was trying to assess what they thought, experiences and tried to describe why they thought as they did, when they listen on three different versions of same musical piece. Without low frequent bass, original and strengthened bass, randomly mixed. Several different musical pieces was used in same survey. The work also makes a commitment to theories about the people's hearing and the will of ?selfmotion?.

Syftet med den här uppsatsen är att undersöka och synliggöra några olika sätt att se på musik som konst (eller icke-konst). Som metod har jag valt att göra kvalitativa intervjuer med fem personer som, på olika sätt och inom olika genrer, skapar musik eller ljudkonst. I intervjuerna har jag försökt ringa in de olika personernas syn på konstbegreppet, på musik i förhållande till detta begrepp samt på deras eget skapande. Resultaten visar på fem individuella synsätt och personliga definitioner av konst. Vilka intervjupersoner som delar varandras synsätt varierar mellan de olika frågeområdena och några generaliserbara slutsatser går inte att dra, vilket inte heller har varit målet med undersökningen.

The history of Banu Umayya has since the collapse of the caliphate occupied a major part in Islamic historiography. The present thesis analyses the presentation of the Umayyads in Ibn Khaldun?s al-Muqaddima and its relation to previous historical traditions. The thesis examines the social and intellectual context in which Ibn Khaldun stood and how it is represented in his historiography, while also providing an overview of the various socio-political, intellectual and historiographical developments in Islam. The theoretical perspectives are based on the concept of agency, examining the intellectual room for manoeuvre that the historian disposed of while composing the works.

Through participant observation in a local promoter group of hardcore punk shows inGothenburg and qualitative interviews with its members I have investigated links between taste in music, values and social structures in the hardcore punk scene. The theoretical framework of this essay is built upon the concept of subcultural capital, which is adapted from Pierre Bourdieu and developed by Sarah Thornton and Keith Kahn-Harris. The result shows how members among the hardcore punk scene create and preserve distinction towards others, while the distinction becomes important benchmarks for including and excluding practices in the scene..

The aims of the present study were to implement and evaluate a three-session Acceptance and Commitment Therapy (ACT) stress management intervention in a non-clinical group of university students (N = 25) and to investigate the importance of practice in an ACT-intervention. A design with pre-test and double post-test was chosen. A comparison was made between a nine-hour ACT-intervention containing practice for the participants, a two-hour lecture on ACT and stress management containing no practice for the participants and a control group. Psychological flexibility was assessed with Acceptance and Action Questionnaire-2 and mindfulness was measured with Kentucky Inventory of Mindfulness Skills. Perceived stress level was measured with Perceived Stress Scale.

Archives can tell us many things about the past. The purpose of this guide is to facilitate the work of those who want to know more about the documents associated with death sentences. The guide gives a brief introduction to the history of the death penalty in Swedish legal history, to the legal process and to the judicial authorities. It also adresses the relationship between the various bodies and the relationship between law and jurisprudence. The guide presents primarily the archives of Nedre justitierevisionen and of Svea hovrätt.

This study examines how upper secondary school teachers in Västerbotten and Österbotten plan to teach about the Finnish War 1808-09. The study includes written interviews with nine teachers in Västerbotten and eight teachers in Österbotten, who have answered questions concerning school policy documents, content and didactic methods. The purpose has been to examine whether there is a difference in historical culture in how the war is treated in the two regions. Historical culture is here meant within the prospective history lesson, where the pupils encounter history within certain boundaries.The result of the interview study shows that there are differences in structure concerning the school policy documents, but that these differences on the whole are compensated by the widespread interest in the Finnish War by the teachers in both regions. The differences in historical culture can be found within the construction of the content when it comes to the aftermaths of the war as well as the purpose of the teaching.

AbstractThis thesis discusses and analyses a 19th century female author's vanishing from history. The study investigates social relationships as figured and described in the epistolary form, based on letters between the author herself and different members of her family. It also tries to identify the author's position and situation in her time and society according to important themes and motifs in her novels. The main purpose is not to reconstruct history, but rather to show the many complex histories that can also be described, apart from the simplified and generalized one. The aim of this study is to, from a post-structuralist perspective, analyze the position of author Marianne Lundegård-Hagberg, and her role as a performative, discursive person that history forgot..