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73 Uppsatser om Histone modifications - Sida 3 av 5

Metodutveckling för analys av serglycinuttrycket i blodet hos hundar :

The development of quantitative, real-time PCR (qPCR) combined with the mapping of the canine genome opens new possibilities in veterinary medicine. This method provides a quick and accurate quantification of the expression of a specific gene at a given point in time and thereby also information of how the gene expression for a certain protein is influenced by various conditions and diseases. One possible area of application is identifying bio markers for cancer. Recently the protein serglycin (the core protein of an intracellular proteoglycan) was found to act as a selective marker for the disease acute myeloid leukemia in humans (Niemann et al, 2007). Serglycin is produced by most hematopoietic cells, although mast cells account for the largest amount of serglycin.

Kan ett tillskott av tryptofan ha en inverkan på  sjukdomstillstånd som depression och/eller smärta?

5-hydroxytryptamin (5-HT) is biochemically derived from Tryptophan. Kynurenic acid and quinolinic acid are also known metabolites of tryptophan. 5-HT is considered to play a role in depression and today selective serotonin reuptake inhibitors (SSRIs) are used for treatment of depression. 5-HT may also play a role in pain perception. The aim of this study was to investigate whether a supplement of tryptophan may affect conditions such as depression and/or pain.

Analys ac konstruktionsprocessen inom FTC

This thesis work was made to optimize the writing of the construction specificationsat FKA. These construction specifications are created before each plant modificationsthat is started because requirements from the Swedish radiation safety authority(SSM) and internally on Forsmarks nuclear group as constructions / implementationdocumentationThe study was done through seven interviews of two people at three different groupsinvolved in the construction specification and an interview from the group accreditedverification. The four selected groups were selected through an extensive analyticalwork resulted in an elimination matrix where these four groups was considered to bemost involved with the construction specification.The questions asked to these individuals were based on the instructions and sampletext that are described in the construction specification. To ensure the quality of thethesis were to limit itself to the chapters that were considered most relevant toimprove. The analysis revealed a number of points that should be improved, partlyinto the routines when writing the construction specification and when ether sampletext or suggestions should be changed and complemented.

Elevers tillämpning av källkritik på Internet

This paper, called Pupils' practice of source criticism on the Internet, is investigating pupils? use of source criticism. The main research question was: how much knowledge pupils from an upper secondary class have about the use of source criticism, regarding examining data from the Internet intended for assignments. Furthermore, developing a suitable method to investigate this was included. The main research question led to further sub questions that aimed to answer to what extent pupils consider source critique criteria as sender, aim, up-to-dateness, credibility and dependence.The study has been conducted by using mixed methods, both qualitative and quantitative methods.

Förbättring av mjukvarubibliotek för parallellberäkningar med programmeringsmodellen Chunks and Tasks

Chunks and Tasks is a programming model based on the C ++ programming language. This programming model is used for electronic structure calculations, among other things.The purpose of this project is to improve the CHT-MPI software library for Chunks and tasks, so that calculations of matrix-matrix multiplications are performed more efficiently than they do with the existing software library. The software library is based on the work stealing method, which is a method the software library for Chunks and Tasks uses for the distribution of the calculation work. The considered way to improve the software library is by modifying the work stealing method in a way that makes the distribution of calculation work happen in a more efficient way , which will lead to calculations performed faster than before.Two different modifications of the work stealing method were tested and it led to two new methods, Method 1 and Method 2, which distributed the calculation work differently. Method 1 did not give results that were compatible with the theory, since the calculation time with this method was much longer than the previous method.

Uppfyller BIM förväntningarna som arbetsmetod för broprojekt?

The purpose of this work is to design and construct a device able to measure the mechanical attrition of oxygen carrier particles. Those particles are used in chemical looping combustion and in the present situation there is a lack of knowledge in how the attrition process work and in which extension. To find already tested solutions trying to answering this problem a literature study wascarried out and the best solution found was the so called Grace-Davison Jet-Cup method. This method is supposed to emulate the attrition caused by a cyclone separator and its advantages are that it is possible to use small test amounts, 5-10 g, and a thirty minutes long test will be enough to acquire useable results. An device was designed based on the Jet-Cup method with some slight modifications.

Konstruktion av anordning för att undersöka förslitning av syrebärarpartiklar för kemcyklisk förbränning

The purpose of this work is to design and construct a device able to measure the mechanical attrition of oxygen carrier particles. Those particles are used in chemical looping combustion and in the present situation there is a lack of knowledge in how the attrition process work and in which extension. To find already tested solutions trying to answering this problem a literature study wascarried out and the best solution found was the so called Grace-Davison Jet-Cup method. This method is supposed to emulate the attrition caused by a cyclone separator and its advantages are that it is possible to use small test amounts, 5-10 g, and a thirty minutes long test will be enough to acquire useable results. An device was designed based on the Jet-Cup method with some slight modifications.

A Long Day?s Journey into Night ? examining the Swedish model, present and future

In this essay we strive to examine how the social work in Sweden will be affected if the Swedish welfare model goes through fundamental changes. The study illuminates the close connection between the Swedish collective bargaining model and the Swedish welfare system. The questions we present in this essay, and hopefully answer satisfactory, are: is the Swedish welfare model subject to thorough changes? How will such a change alter the social work in Sweden?, is the Swedish collective bargaining model in a state of modification? Would a modification in the collective bargaining model have effects on the Swedish welfare model?We have used a qualitative method in collecting empirical material. We interviewed three representatives, who worked for Confederation of Swedish Enterprise, IF Metall and The Swedish Municipal Workers respectively.

Centralisering och decentralisering: En fallstudie på Apoteket och Swedbank

Multi-branch companies are facing many challenges in order to become successful. Competitive advantages can be gained through a unified strong brand, standardised products and economies of scale. This normally calls for centralisation. On the contrary is decentralisation, which is said to improve work motivation and local market orientation, which are also competitive advantages. The focus of this thesis is to study how local branch managers want their companies to be structured in accordance with this dilemma.

Med avfall upp till knäna - En osteologisk studie av tafonomi och medeltida avfallshantering i kvarteret Blekhagen i Lund

The subject of this master level thesis in historical osteology, is a study of waste management in the medieval town of Lund. The aims of the study is achieved through looking at the taphonomic aspects of bonefragments from the quarter Blekhagen. The study is divided in two separate sections, one that is a litterature study of what is known about waste management, and another one that contains a taphonomic and spatial analysis. Through examination of the taphonomic variables weathering, average weight and trampling and a spatial analysis, I am able to deduce that there are signs of controlled waste management in the material. It is not possible to draw any general conclusions about waste management in the medieval town however.

CFD-simulering av kallras från fönster : Konvektorers och nischdjupets inverkan på lufthastigheter i rummet

During cold winter days it is likely that people in buildings with older windows or high glass facades experience thermal discomfort due to cold air down draughts. Earlier work has been aimed at finding analytical methods to predict the speed of the airflow in a room and in practice heating appliances are often placed beneath the windows to reduce the draught along the floor. In a study from 2012 Mohammad Parchami developed a method for estimating the required heating power to counteract the downdraught with such heating appliances. In this study, Computational Fluid Dynamics (CFD) was used to evaluate the usefulness of Parchami?s method and also to examine the potential of adapting the depth of the inward window sill as a means of decreasing the down draught.

Arbetsterapeutiska åtgärder som främjar delaktighet i dagliga aktiviteter hos personer med demenssjukdom

Andelen äldre i samhället har ökat och därmed har även förekomsten av demenssjukdomar tilltagit. Aktivitet är av stor betydelse för personer med demenssjukdom, dock påverkar sjukdomen ofta individens aktivitetsförmåga och det kan bli svårt att utföra dagliga aktiviteter. Syftet med studien var därför att kartlägga och beskriva arbetsterapeutiska åtgärder som främjar delaktighet i dagliga aktiviteter hos personer med demenssjukdom. En litteraturstudie genomfördes, och datainsamlingen skedde både genom en systematisk sökning i databaser och genom sekundär sökning. Sammanlagt inkluderades 14 vetenskapliga artiklar i studien.

Energieffektiv design av ett inbyggt flashminneshanteringssystem

The report is the result of a master thesis at ENEA AB during the fall of 2009. Itaims to create a specification of flash memory management system which focuseson power efficiency and low RAM usage for embedded systems, and to design andimplement a prototype of such a system to facilitate further development toward thecreated specification. The system used by ENEA today is a Flash Translation Layer(FTL). It has a complex structure which prohibits modifications and customization,therefore a new flash memory management system needs to be developed.The suggested solution uses a translation layer called Metadata FTL (MFTL), wherefile system metadata and userdata are separated from each other in order to improveperformance. The partition holding userdata uses a block-level mapped translationlayer system called Fully Associative Sector Translation FTL.

Integrerad arbetsprocess mellan projektör och konstruktör, För effektiv och kvalitetssäker projektering med Tekla Structures och SAP2000

The purpose of this work is to design and construct a device able to measure the mechanical attrition of oxygen carrier particles. Those particles are used in chemical looping combustion and in the present situation there is a lack of knowledge in how the attrition process work and in which extension. To find already tested solutions trying to answering this problem a literature study wascarried out and the best solution found was the so called Grace-Davison Jet-Cup method. This method is supposed to emulate the attrition caused by a cyclone separator and its advantages are that it is possible to use small test amounts, 5-10 g, and a thirty minutes long test will be enough to acquire useable results. An device was designed based on the Jet-Cup method with some slight modifications.

Ett skenbart anställningsskydd? : En arbetsrättslig studie av förutsättningarna för otillbörligt kringgående av reglerna om företrädesrätt tillåteranställning

The Employment Protection Act (1982:80) provides provisions regarding priority of re-employment. A few cases where these provisions have been subject to examination, have been discussed thoroughly in SOU 2014:55. In these cases the Labour Court has identified the question whether the provisions regarding priority of re-employment can be subject to circumvention in an illegal manner. The Labour Court has stated that it would be incompatible with the sense of justice if the provisions could be circumvented to the detriment of employees entitled to priority of re-employment. However, the Labour Court stated that certain conditions have to be imposed for the assessment.After analysis of the conditions, it is established that they are deemed to cause major difficulties for employees, why it is held that the purpose and the function of the conditions are not achieved. The purpose of the essay is therefore to investigate whether the application of the conditions imposed by the Labour Court, need to undergo modifications to meet the underlying purpose of the creation of the conditions.By reason of the difficulty with the conditions, the essay provides three different amendments in which two of the amendments are ascertained to not contribute to such an improvement that they should actually be applied.

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