The castle Vivesholm is located about two miles north of Klintehamn on the west side of Gotland. The castle was built around year 1395 and burned down in the end of the 14thcentury. Around the 17th and the 18th century the castle was re-used. However, the emphasis on its use is during the middle ages.This paper aims at getting an insight in the animal husbandry at Vivesholm by analyzing the osteological material. The analysis revealed that bones from sheep/goat were more common than bones from cattle.

Breast cancer is the most common tumor disease among women in Sweden. About 7000persons, having a median age of 65, are diagnosed each year with this disease. Withmammography screening, breast cancer can be detected in an early stage which improves theoverall survival (OS). 20-30 % of the breast cancer tumors are overexpressing humanepidermal growth factor receptor 2 (HER2), which is a protein that stimulates cell proliferation.Trastuzumab (Herceptin®) is a humanised monoclonal antibody that targets the HER2-proteinand prevent the signals for cell proliferation.Trastuzumab has earlier been used for treatment of metastatic breast cancer. In the year of 2007trastuzumab was approved for adjuvant treatment of patients who has been medicated withsurgery and/or radiation.The aim of this study was to investigate the effects of adjuvant treatment with trastuzumab inHER2-positive breast cancer patients.

In Lake Vänern, Sweden, there is an endemic population of Atlantic salmon (Salmo salar L.) that lives its entire life in fresh water. The salmon is hindered from migrating to its natural spawning sites in the northern part of the River Klarälven by nine hydro-electric power plants. None of the hydro-electric power plants have Fishways so that salmon migrating upstream or downstream may pass. In the current situation, the upward migrating salmon are caught in a Fish trap at the most downstream located power plant in Forshaga. From there, the salmon are driven in a truck, past eight power plants and released a few kilometers upstream of the eighth power plant at Edsforsen.

Antifouling paint containing the biocide bisTributyltinoxide (TBTO) has been used since1960 to reduce the occurrence of fouling on hulls on boats/ships. January 1st, 2003 theantifouling paints containing TBTO were prohibited. This ban covered all use of paintcontaining the substance TBTO. The ban was introduced because of alarming observationssuch as development of imposex in aquatic non-target organisms. Imposex is the impositionof male sexual characteristics on mainly female marine snails and occurs due to exposure toTributyltin (TBT).

Breast cancer is the most common tumor disease among women in Sweden. About 7000persons, having a median age of 65, are diagnosed each year with this disease. Withmammography screening, breast cancer can be detected in an early stage which improves theoverall survival (OS). 20-30 % of the breast cancer tumors are overexpressing humanepidermal growth factor receptor 2 (HER2), which is a protein that stimulates cell proliferation.Trastuzumab (Herceptin®) is a humanised monoclonal antibody that targets the HER2-proteinand prevent the signals for cell proliferation.Trastuzumab has earlier been used for treatment of metastatic breast cancer. In the year of 2007trastuzumab was approved for adjuvant treatment of patients who has been medicated withsurgery and/or radiation.The aim of this study was to investigate the effects of adjuvant treatment with trastuzumab inHER2-positive breast cancer patients.

This paper deals with diet and gender in the early roman iron age in Sweden. Human bone and tooth material from the Iron Age cemetery at Bjärby in Kastlösa parish on the island of Öland have been analysed for stable carbon and nitrogen isotopes. 21 individuals were sampled. Where possible 4 samples were taken from each individual, from the first, second and third molar respectively and from one compact bone. By doing so it is possible, at least in theory, to trace intra-individual diets throughout life.

By examine cremated remains from graves dated to late Iron Age I wanted to find out what sorts of animals were placed in the graves. But also to see if the animal sacrifices had any connection to the Old Norse religion. The osteological material that were analysed were from both cremated humans and animals and had been dated to Viking Age. The material is from burial ground 59 at Laxare, Boge parish on Gotland. In addition to the human remains, the material contains bones from horse, cattle, sheep/goat, pig, dog, cat, bear, birds and Fish.

Many people choose to live in urban environments. Since everyday life in many cities is characterized by a high pace it is important that good recreational areas, with the possibility of recovery, are available to the population.This paper is based on a case study of Växjö city park, which is the area surrounding the lake Växjösjön. The park and the lake are of great importance to the citizens. The lake Växjösjön has for a long time been affected by eutrophication, which has caused major problems as algal blooms and Fish mortality. An extensive lake restoration was carried out in the 1990s in order to save the lake.

The survival of hatchery reared smolts is generally low after release. To get a better understanding of what variables affecting migration success, Atlantic salmon smolts were studied during their out-migration in the old river channel in the lower part of river Umeälven. The area consists of shifting habitat and complex structures which causes difficulties for smolt on their migration out to sea. The aim of this study was to try to determine the effects of feed restriction, fin conditions and different physical barriers in the river, on the migratory behavior of Atlantic salmon smolts in the river Umeälven. The river was divided into six different sections using acoustic receivers strategically deployed along the river. Two-year old hatchery-reared smolts (n=150), in three different weight classes, were tagged with acoustic transmitters.

Resebyråerna växer i allt stadigare takt, allt eftersom fler människor väljer att färdas med flyg på grund av den effektiva globaliseringen som pågår världen om. Ving och Fritidsresor är två resebyråer som följt med utvecklingen sedan mitten av 1900-talet och har nu blivit två av de ledande resebyråerna i Sverige.Därmed är det intressant att göra en jämförelse mellan dessa och se om det finns några påtagliga likheter eller skillnader. Detta arbete kommer att beröra Ving och Fritidsresors konkurrens för- och nackdelar ur ett kundperspektiv. Det har tagits fram med hjälp av konkurrensmedelsmixen, sexhörningen som består av följande sex hörn, geografi, sortiment, kommunikation, människor, service och pris. För att ta reda på hur betydelsefulla hörnen är för kunden och hur de upplever att Ving och Fritidsresor möter deras behov.Undersökningen har gjorts med hjälp av en kombinerad enkätundersökning av kvantitativ- och kvalitativa frågor som senare har jämförts med aktuell teori.

With the climate change issues growing in importance on the social agenda, the field of urban masterplanning is of no exception when it comes to minimizing the carbon footprint in a variety of projects. The aim of this thesis has been to prepare the Carbon Critical Masterplanning tool, a software plugin for carbon dioxide emissions assessment developed by Atkins, to be used in Swedish conditions. The main targets were to improve the areas of the tool associated with energy conversion and renewable energy sources, and to test the tool in a real case. A planned construction of a new campus in Albano, Stockholm was chosen for the pilot study. A 3D model was built in the tool and the carbon footprint was calculated for a variety of combinations for energy supply to the future area.

Pharmaceuticals are environmental pollutants that are a major threat to aquatic ecosystems and very little is known about their ecological consequences. In this study growth, survival and behaviour (sociability, activity and boldness) of perch fry (Perca fluviatilis) were examined in order to study the possible effects of exposure to a benzodiazepine anxiolytic drug, Oxazepam, during embryonic development. The study tested following hypotheses: (1) perch growth is affected positively by exposure during embryonic development; (2) early perch survival is affected positively by exposure during embryonic development; and (3) boldness and activity increases while sociability decreases in perch fry exposed during embryonic development. Embryos of naturally spawned perch were exposed to water with two different concentrations of Oxazepam. The embryos were exposed during different parts (24-hour periods) of the embryonic development, because embryos may be more vulnerable at certain times during embryonic development and/or because the exposure at different times can produce different effects.

The population of seatrout and salmon are threatened by over-Fishing in the sea and loss of spawning and growing habitats caused by logging activities in many swedish rivers. The knowledge of the spawning migration and the habitat use of the seatrouts and salmon are limited. This study analyse the upstream spawning migration of Atlantic salmon and sea-running brown trouts from the lower part of the rivers to their spawning sites in the rivers Vindelälven and Piteälven. A knowledge about the distribution of spawning sites in the rivers will help these Fish population in future restoration programs. In the Fishladder at Norrfors in the river Umeälven were 29 sea trout and 20 salmon radio tagged and subsequently released and followed during their spawning migration upstream Vindelälven. They were tracked on their position in the river once a week.

Sahlgrenska Academyat University of GothenburgDepartment of Internal Medicin and Clinical NutritionAbstractTitle: Does supplementation of omega-3 during pregnancy affectprevalence of allergy in infants and children?Author: Peter Eliasson, Anna RahmSupervisor: Lena HulthénExaminer: Anna WinkvistProgramme: Dietician study programme, 180/240 ECTSType of paper: Examination paper, 15 ECTSDate: 2012-04-12BackgroundEpidemiologic research has shown an association between a high intake of Fish and allergy.The underlying theory is that allergy develops already at a prenatal stage and food intakeduring pregnancy has been shown to be significant. Conducting research on allergy isproblematic since it has genetic, as well as enviromental, determinants.ObjectiveThis thesis attempts to conclude and evaluate research on a connection betweensupplementation of omega-3 during pregnancy and allergic outcomes in infants and children.Search strategyThe literature search was conducted in the databases PubMed and Scopus. Among thekeywords chosen were omega 3, supplement, pregnancy and allergy.Selection criteriaHuman RCT, that measured allergy, where the intervention consisted of supplementation withomega-3 for at least ten weeks during pregnancy and ceased at birth.Data collection and analysisThree articles were chosen for this thesis. The articles were examined using templates fromSBU and the quality of evidence was evaluated according to GRADE.Main resultsNone of the articles showed a protective effect on allergic outcome but in one of the studiesthere was significant reduction in eggallergy and another showed significant lower occurrenceof severe eczema.ConclusionsSupplementation with omega-3 during pregnancy does not occur to have an protective effecton allergic outcome in infants and childen but the evidence for this is considered to bemoderate.

This report deals with life-history variation for Eurasian perch (Perca fluviatilis L.), with special emphasis on age and size at maturity in females, in perch populations that have changed in size distribution. The collection of Fish samples was made with multimesh gill nets year 2011. The perch?s length, height, weight, status of gonads has been analyzed, and by observing the opercular bone the age has been determined. In two lakes close to Umeå in northern Sweden, Fisksjön and Ängersjön, the live-history traits of perch have been studied.