Kan supplementering med omega-3 under graviditet påverka allergiprevalens hos barn?
Sahlgrenska Academyat University of GothenburgDepartment of Internal Medicin and Clinical NutritionAbstractTitle: Does supplementation of omega-3 during pregnancy affectprevalence of allergy in infants and children?Author: Peter Eliasson, Anna RahmSupervisor: Lena HulthénExaminer: Anna WinkvistProgramme: Dietician study programme, 180/240 ECTSType of paper: Examination paper, 15 ECTSDate: 2012-04-12BackgroundEpidemiologic research has shown an association between a high intake of fish and allergy.The underlying theory is that allergy develops already at a prenatal stage and food intakeduring pregnancy has been shown to be significant. Conducting research on allergy isproblematic since it has genetic, as well as enviromental, determinants.ObjectiveThis thesis attempts to conclude and evaluate research on a connection betweensupplementation of omega-3 during pregnancy and allergic outcomes in infants and children.Search strategyThe literature search was conducted in the databases PubMed and Scopus. Among thekeywords chosen were omega 3, supplement, pregnancy and allergy.Selection criteriaHuman RCT, that measured allergy, where the intervention consisted of supplementation withomega-3 for at least ten weeks during pregnancy and ceased at birth.Data collection and analysisThree articles were chosen for this thesis. The articles were examined using templates fromSBU and the quality of evidence was evaluated according to GRADE.Main resultsNone of the articles showed a protective effect on allergic outcome but in one of the studiesthere was significant reduction in eggallergy and another showed significant lower occurrenceof severe eczema.ConclusionsSupplementation with omega-3 during pregnancy does not occur to have an protective effecton allergic outcome in infants and childen but the evidence for this is considered to bemoderate. A reduction in eggallergy by supplementation is also considered to be moderatewhile an reduction in the severity of eczema is low.