It generally takes 10 to 12 years for a new drug to hit the market. The pharmaceutical industry invests huge sums in these Early stages of research and development. In spite of the rapidly rising research and development expenditures fewer and fewer blockbuster drugs are being developed. Longer lead times and aggressive generic post-patent competition have narrowed the timeframe for the pharmaceutical companies to profit on their investments.In the face of these threats the pharmaceutical industry has developed a battery of strategies to prolong market exclusivity and to maximize return on investment. These emerging strategies are commonly known as Life cycle management (LCM), which actually is more of a concept than a method.

The Swedish government have a goal that wind turbines shall produce 30 TWh by the year 2020, compared to about 3,5 TWh produced in Sweden during 2010. To minimize the disturbance that wind turbines create the Swedish Environmental Protection Agency has stated a guideline value that noise from wind turbines at nearby residents shouldn?t exceed 40 dBA, at 8 m/s wind speed. With advanced calculation models, like Nord 2000, the emitted sound from future wind turbines can be calculated at an Early stage to optimize the power production without exceeding the 40 dBA. When the turbines have been built there is a need to verify that they really are within the guideline.

Swedish horse breeders have generally very few mares producing a few foals a year and the breeders have relatively few traditions, little knowledge and experience to breed foals successfully. It is therefore important to provide adequate information about new findings in horse nutrition. However, there is not much research about feeding the suckling foal to ensure a sound growth. Current feeding recommendations in the literature seems to be different. This gives a confusing message and the information is difficult to apply. This paper reviews some publications in the area of feeding the suckling and weaning foal. Most authors stress that it?s important to start feeding the foal early in life.

The aim of this undergraduate thesis was to formulate advices regarding the use of field beans, cultivated together with spring wheat, as whole-crop silage in feeding to dairy cows. In the thesis, optimal harvest time of the field bean/spring wheat crop, as well as the feeding value and the fermentation quality, was studied. On the research station at Röbäcksdalen in Umeå field bean/spring wheat (70 % respective 30 % of normal seed rate for the pure crop) and pea/oat (70/30) was grown in field experiments both 2002 and 2003. The following year, 2004, the pea/oat crop was excluded and instead field bean and spring wheat was cultivated in three different mixed ratios (field bean/spring wheat; 100:0, 70:30, 30:70). Every year the crops were harvested at four different development stages and the green forages were used in ensiling experiments.

This study aims to assess the normal inflow of extraterrestrial chromite to Earth. The results from the investigationare compared to earlier studies of middle Ordovician Orthoceratite Limestone in which 1 - 3 extraterrestrial chromitegrains ( >63 ?Êm ) per kilogram limestone were found. These values have been interpreted as evidence of a twoorders of magnitude increase in the flux of extraterrestrial matter to Earth during a part of middle Ordovician.From an early Paleocene marine sedimentary sequence with known sedimentation rate in Zumaia, northernSpain, 90,5 kilogram of condensed limestone, dated to about 63 Ma, was sampled. The limestone was dissolved inhydrochloric- and hydrofluoric acid and the residue was sieved and searched for opaque minerals under the binocularmicroscope.

This paper deals with the question of whether the symbolic language of the late Neolithic and middle Bronze Age was transferred from ceremonial monuments and barrows into the domestic sphere in the late Bronze Age. I will consider such elements as doorway orientation, the significance of boundaries and depositional practices to see if Early-Middle Iron Age settlements were indeed a major scene for ritual behaviour..

Most of today?s concrete structures that are built on site are mainly constructed in a traditional fashion with a lot of artisanal operations. One step towards industrializing the in-situ construction of concrete is to use prefabricated reinforcement. Through this method there can be a lot of savings when each bar doesn?t have to be placed and fixed separately on site.

The purpose of this study has been to examine reading habits and the use of the library by pre­school teachers in a mainly multicultural community, and also explore to what extent activities in the local library are aimed at preschoolers.The study used a sociocultural approach based on Vygotsky?s theories of learning and development and Söderbergh?s theory of early childhood language development, and was carried out during the summer 2009. The methodology used was both quantitative and qualitative, with a combination of questionnaires and interviews. Questionnaires were sent out to each section of the municipal pre­schools within the catchments area of the local public library in a multicultural suburb of Uppsala. Three short interviews were carried out with staff at the local and main library branches, as well as library staff at the County Council.The results show that, although preschool teachers find reading important in their work, many teachers read spontaneously and/or sporadically.

AbstractMy feature career as a teacher, for the early years of compulsory school, makes it interesting to finding out of how teaching religion can be donned. I am interested in what methods can be used for teaching religion That?s why my purpose aims to find out how five different teachers, of the early ages, works and what methods they use while teaching religion. My issue for this composition is: what methods, or to a point - methods supported by different teaching models, can be used for studying religion in compulsory school? Empirical and specialized literature points in the direction fore methods like storytelling, load reading, drama, group works, independent searching of information, working books and so on.

This study aims to find out what happens with the roles that are seemingly left behind. Are there roles that are harder or easier to exercise? Available roles with us through life and affect our future decisions or we switched completely away from them and create new roles based on the situations we find ourselves in at the moment? The aim is also to see how the relationship looks like between closed roles and new roles in life. To try to find this out, I have used the narrative method. The study is based largely on Goffman's theories of roles, behind and above the front- and back stage.

Vår studie är gjord för att se om det finns någon skillnad i mellanstadieelevers beteenden i klassrum respektive idrottshall. Våra frågeställningar är: Finns det skillnader i beteendena hos mellanstadieelever i idrottshallen respektive i klassrummet? Finns det några skillnader mellan pojkars och flickors beteenden? Hur yttrar sig eventuella skillnader och vad beror de på? För att komma fram till detta har vi använt oss av observationer som metod och observerat årskurs fem-klasser på två olika skolor. I arbetet har vi kopplat vår empiri till Connells teori om hegemonisk maskulinitet och Goffmans beteendeteori Front-stage och backstage. Vi har också använt oss av behaviorismens grundläggande tankar om hur en miljö kan påverka ett beteende.

To differentiate between bones from sheep (Ovis aries) and bones from of goats (Capra hircus) is a long lasting challenge for zoologists, archaeozoologists and osteologists. Especially considering archaeological remains which are often found fractured and poorly preserved due to taphonomic processes. Zeder & Pilaar?s (2010) and Zeder & Lapham?s (2010) methods of species differentiation has shown promising results when used on bones from modern sheeps and goats. This paper aims to evaluate these methods by exerting them on excavated bones from kv.

Inspired by the great arts of scientist and poet Robert J. Oppenheimer, the purpose of this paper is to unveil and highlight the attitudes towards the atomic bomb in Swedish newspapers during the early and most vivid years of the atomic era. By pinpointing and analysing central discourses caused by this paradigm breaking invention, this academic effort reveals the morbid moral of the story caused by loose speculations and the lack of knowledge..

It is a well known archaeological concern that the remains of human bones left from the bronze age and early iron age Scandinavia are not nearly enough to represent the estimated population of the time. Furthermore the bones of each find rarely represent a whole individual. The majority of the bones must have been disposed of somewhere else, possibly scattered in running waters or in the fields, where they have evaporated or are securely hidden from archaeological excavations.This thesis deals with the grave concept and the problem in using a word that is so very clouded by its modern, western meaning. It also offers an alternative explanation to why the bones are handled the way they are and why they are found in such awkward contexts..

This essay describes the phases of funeral rituals between the Syrian/Assyrian, and compares the homeland with Sweden. It describes the stage of rituals according to Victor Turner schema of separation, margin or limin, and aggregation. The rituals religious significance agrees with Clifford Geertz?s theory about the importance of religious beliefs for the human being.