It generally takes 10 to 12 years for a new drug to hit the market. The pharmaceutical industry invests huge sums in these early stages of research and development. In spite of the rapidly rising research and development expenditures fewer and fewer blockbuster drugs are being developed. Longer lead times and aggressive generic post-patent competition have narrowed the timeframe for the pharmaceutical companies to profit on their investments.In the face of these threats the pharmaceutical industry has developed a battery of strategies to prolong market exclusivity and to maximize return on investment. These emerging strategies are commonly known as Life cycle management (LCM), which actually is more of a concept than a method.

Swedish horse breeders have generally very few mares producing a few foals a year and the breeders have relatively few traditions, little knowledge and experience to breed foals successfully. It is therefore important to provide adequate information about new findings in horse nutrition. However, there is not much research about feeding the suckling foal to ensure a sound growth. Current feeding recommendations in the literature seems to be different. This gives a confusing message and the information is difficult to apply. This paper reviews some publications in the area of feeding the suckling and weaning foal. Most authors stress that it?s important to start feeding the foal early in life.

This paper deals with the question of whether the symbolic language of the late Neolithic and middle Bronze Age was transferred from ceremonial monuments and barrows into the domestic sphere in the late Bronze Age. I will consider such elements as doorway orientation, the significance of boundaries and depositional practices to see if Early-Middle Iron Age settlements were indeed a major scene for ritual behaviour..

The purpose of this study has been to examine reading habits and the use of the library by pre­school teachers in a mainly multicultural community, and also explore to what extent activities in the local library are aimed at preschoolers.The study used a sociocultural approach based on Vygotsky?s theories of learning and development and Söderbergh?s theory of early childhood language development, and was carried out during the summer 2009. The methodology used was both quantitative and qualitative, with a combination of questionnaires and interviews. Questionnaires were sent out to each section of the municipal pre­schools within the catchments area of the local public library in a multicultural suburb of Uppsala. Three short interviews were carried out with staff at the local and main library branches, as well as library staff at the County Council.The results show that, although preschool teachers find reading important in their work, many teachers read spontaneously and/or sporadically.

AbstractMy feature career as a teacher, for the early years of compulsory school, makes it interesting to finding out of how teaching religion can be donned. I am interested in what methods can be used for teaching religion That?s why my purpose aims to find out how five different teachers, of the early ages, works and what methods they use while teaching religion. My issue for this composition is: what methods, or to a point - methods supported by different teaching models, can be used for studying religion in compulsory school? Empirical and specialized literature points in the direction fore methods like storytelling, load reading, drama, group works, independent searching of information, working books and so on.

To differentiate between bones from sheep (Ovis aries) and bones from of goats (Capra hircus) is a long lasting challenge for zoologists, archaeozoologists and osteologists. Especially considering archaeological remains which are often found fractured and poorly preserved due to taphonomic processes. Zeder & Pilaar?s (2010) and Zeder & Lapham?s (2010) methods of species differentiation has shown promising results when used on bones from modern sheeps and goats. This paper aims to evaluate these methods by exerting them on excavated bones from kv.

It is a well known archaeological concern that the remains of human bones left from the bronze age and early iron age Scandinavia are not nearly enough to represent the estimated population of the time. Furthermore the bones of each find rarely represent a whole individual. The majority of the bones must have been disposed of somewhere else, possibly scattered in running waters or in the fields, where they have evaporated or are securely hidden from archaeological excavations.This thesis deals with the grave concept and the problem in using a word that is so very clouded by its modern, western meaning. It also offers an alternative explanation to why the bones are handled the way they are and why they are found in such awkward contexts..

Inspired by the great arts of scientist and poet Robert J. Oppenheimer, the purpose of this paper is to unveil and highlight the attitudes towards the atomic bomb in Swedish newspapers during the early and most vivid years of the atomic era. By pinpointing and analysing central discourses caused by this paradigm breaking invention, this academic effort reveals the morbid moral of the story caused by loose speculations and the lack of knowledge..

Gotland is an island with a rich history. One unique thing about it is the picturestones. There are, today, 565 known stones and fragments found on the island of various dating. The dating time spans from 400 ad to 1100 ad. This essay is meant to discuss the dating issue of the early picture stones dated to 400-700 ad and discuss the relevance and validity of the today?s dating.

The aim of this study is to describe a number of type stands of lodge pole pine in Norrbotten with respect on stem volume and total biomass. Further questions to answer is if there is stand characteristics that make the stands more suitable for pulpwood in early thinning, or if it is better to apply whole tree harvest. The study shall also give an indication if bio energy can be an economical interesting alternative for Sveaskog. Sampled trees represented the variation in the different stands. Five trees were selected from each stand to represent that stand. Stem volume and biomass (kg dry weight (DW) per hectare) for each fraction was calculated.

It is a well known archaeological concern that the remains of human bones left from the bronze age and early iron age Scandinavia are not nearly enough to represent the estimated population of the time. Furthermore the bones of each find rarely represent a whole individual. The majority of the bones must have been disposed of somewhere else, possibly scattered in running waters or in the fields, where they have evaporated or are securely hidden from archaeological excavations.This thesis deals with the grave concept and the problem in using a word that is so very clouded by its modern, western meaning. It also offers an alternative explanation to why the bones are handled the way they are and why they are found in such awkward contexts..

It is a well known archaeological concern that the remains of human bones left from the bronze age and early iron age Scandinavia are not nearly enough to represent the estimated population of the time. Furthermore the bones of each find rarely represent a whole individual. The majority of the bones must have been disposed of somewhere else, possibly scattered in running waters or in the fields, where they have evaporated or are securely hidden from archaeological excavations.This thesis deals with the grave concept and the problem in using a word that is so very clouded by its modern, western meaning. It also offers an alternative explanation to why the bones are handled the way they are and why they are found in such awkward contexts..

It is a well known archaeological concern that the remains of human bones left from the bronze age and early iron age Scandinavia are not nearly enough to represent the estimated population of the time. Furthermore the bones of each find rarely represent a whole individual. The majority of the bones must have been disposed of somewhere else, possibly scattered in running waters or in the fields, where they have evaporated or are securely hidden from archaeological excavations.This thesis deals with the grave concept and the problem in using a word that is so very clouded by its modern, western meaning. It also offers an alternative explanation to why the bones are handled the way they are and why they are found in such awkward contexts..

År 2013 var den globala omsättningen för modeindustrin ca 76 tusen miljarder svenska kronor (Office of Textiles and Apparel, 2014). Bara i Sverige omsattes det 229 miljarder svenska kronor år 2012 inom denna sektor, en ökning på 11 % från föregående år (Tillväxtverket, 2014). Att modebranschen är under ständig utveckling och ökar i tillväxt kan man se då dessa siffror stiger varje år. Statistik från 2014 visar att trots denna ökning så överlever endast 47 % av nystartade modeföretag de tre första åren (Statistic Brain, 2014). Så hur lyckas man som modeföretag i early stage-fasen att med begränsade resurser stärka sitt varumärke och hålla sig kvar på marknaden? I denna studie berörs olika delar så som traditionell marknadsföring, okonventionell marknadsföring, branding samt transparens, där huvudfokus ligger på företag i early stage- fasen av sin uppstart.

This paper deals with stable isotope analysis on the children of the early Christian cemetery in Varnhem, Västergötland. Human bone and tooth material from the cemetery has been analysed for stable carbon, nitrogen and sulphur isotopes. The analysis showed that the diet had been homogeneous and that the children had been breastfed, with a possible exception of the child from grave 100..