Determination of serum thymidine kinase 1 (TK-1) activity is used as a tumour marker in both human and veterinary medicine. TK-1 is an intracellular enzyme involved in a salvage pathway of DNA synthesis. The expression of TK-1 is cell cycle dependent and the activity increases markedly after the G1 to S transition in the cell cycle and then declines rapidly in G2. The pronounced proliferative activity in tumour cells result in a higher TK-1 enzyme activity within the cell. The fact that the increased TK-1 activity can be measured in serum makes TK-1 a useful marker in diagnostics of neoplastic diseases and it provides information regarding prognosis and treatment effectiveness. In human medicine a radioactive based test is used to determine the TK-1 serum activity.

Picropodophyllin (PPP) is an analogue of the anti tumour lignan podophyllotoxin with the unique ability to selectively inhibit the receptor of Insulin like growth factor 1(IGF-1). IGF-1 is believed to play an important part in development of the endometrium facing implantation. With PPP treated mice, studies can be made to measure gene expression from tissue of both treated and untreated mice to compare the role of IGF-1 regarding ovulation, implantation and receptivity. The aim of this study was to analyze gene expression of some steroid hormone receptors and cytokines in ovaries from mice treated with PPP. In this study, seven mice were treated with PPP at different times and tissue was collected.

Cardiovascular disease is the leading cause of death in the Western world. For persons who have had a myocardial infarction the following rehabilitation and the group training, which is a part of this, are very important. The cardiac rehabilitation is designed to limit the physiological and psychological effects of cardiovascular disease. Purpose: This study aimed to examine how patients with cardiovascular disease experienced group training in relation to the International Classification of Function, Disability and Health, ICF. Method: A qualitative interview study was performed according to Malterud, inspired by the Grounded Theory method.

Venous leg ulcers are a chronic disease mostly among elderly individuals. The leg ulcers are often painful and interfere with the individual?s daily life. The aim of this literature review was to describe individuals? experiences of living with venous leg ulcers.

It is well known that dogs often have Helicobacter spp in their stomach. The importance of these bacteria in the development of gastrointestinal disease in dogs is still unknown. In humans, Helicobacter pylori is a causative agent of chronic gastritis and gastric ulcers. In contrast to humans, dogs seldom harbour naturally acquired H. pylori.

Det här examensarbetet undersöker om ett anatomiskt system framtaget för att kategorisera ansiktsrörelser inom psykologisk forskning kan anpassas på en ansiktsrigg för att effektivare kunna framställa ansiktsanimation för datorspel. Rapporten beskriver varför Facial Action Coding System skapades, hur det används samt tar upp olika sammanhang som systemet tidigare använts för. Rapporten beskriver det praktiska arbetet för att konstruera en ansiktsrigg ämnat för datorspel och diskuterar skillnader mellan att rigga för datorspel och film. Examensarbetet beskriver klassiska användbarhetsprinciper och vad man bör tänka på när produkten skall bli så användningsbar som möjligt. Ett animationsverktyg baserat på FACS och de ?Action Units? som systemet innehåller har tagits fram för att genomföra undersökningen på animatörerna från min praktikplats på Starbreeze Studios AB.

The aim of this study is to create a deeper understanding of the disease known as eating disorder. The study is based on four autobiographies written by individuals who themselves have been affected by eating disorders. These stories have been studied using a narrative approach. To achieve the purpose, the study is focused on what participants describe as the factors underlying the onset of the disease, the factors that participants describe maintained their eating disorders, as well as what is described to be the factors responsible for their recovery. By my interpretation of the stories, I have been able to identify common factors that all participants describe to be influential in their disease course.

Patients with COPD (chronically obstuctive pulmonary disease) often experience acute episodes of the disease. On these occasions it is usual that the ambulance nurse is the patients first contact in the care. The purpose of this study is to describe patients' experiences in acute condition of the disease COPD and the Pre-hospital nursing. The method was systematic literature review with content analysis. The results show four prominent themes on the basis of patients' experiences.

The alpaca is a camelid that originate from the South American highland. During recent years it?s been possible to keep alpacas in other parts of the world. Today there is a world-wide interest in alpacas, but there is still limited knowledge about this fascinating animal. There are approximately 350-400 alpacas in Sweden in 2007.

Background: Vaccination is an important part in cats? welfare. It both helps to prevent the individual cat from catching a disease or lessen the symptoms of it, and protects the entire cat population from an epidemic. It is the cat owner who makes the decision to vaccinate or not. Understanding the cat owners? perspective regarding vaccination may improve communication between the owner and the veterinary nurse, which may lead to a higher vaccination rate among cats.

Venous leg ulcers are a chronic disease mostly among elderly individuals. The leg ulcers are often painful and interfere with the individual?s daily life. The aim of this literature review was to describe individuals? experiences of living with venous leg ulcers.

Introduction: More and more children and young people get the diagnosis celiac disease established. Celiac is a life-long disease, which means that the child during the rest of its life has to be on a strictly gluten-free diet. There are few studies so far, which have examined how children having a life-long disease with food treatment and increasing prevalence really experience their health related quality of life (HRQoL).Purpose: The purpose of the study was to examine how children (8 ? 18 years old) suffering from celiac valued their HRQoL and to illustrate as well whether the age of the child and its extent of disease when it was taken ill affected the child?s evaluation of HRQoL later in life. The purpose was also to compare whether the children?s parents valued the HRQoL of their children to the same extent as the children did.Method: 160 children, 54 boys and 102 girls were included in the study.

BackgroundThe lifeworld describes the experience of being a humanbeing, how we experience life and how we live our lifes. When a disease, such as depression occurs, the whole lifeworld can be filled with suffering. Depression is an affective disease, which means it involves the emotions. The patient gets dejected and the emotional devotion abates. Broken sleep, anxiety, pain, concentrations difficulties, fatigue and reduced appetite is some of the symptoms.

With good knowledge about the disease and the treatment, the fear and worry of children and parents can be reduced. Children may be helped by painting to express their experiences. In order to have a good care, the care-personnel need to see and understand what the children need. It is important to live an as regular life as possible during the disease and its treatment. The aim of this study was to elucidate how children experience chemotherapy in conection with their cancer disease.

How a speaker can use their posture, gesture, facial expression and voice to create a strong ethos, pistis and sense of trustworthiness is, in this paper, associated with charisma (the power of leadership or authority).Verbal and nonverbal expressions from three particular speeches by Martin Luther King, John F Kennedy and Bill Clinton have been analyzed in depth. The results show that patos as well as strong nonverbal expression are factors in inspiring devotion or creating enthusiasm. Personal magnetism and radiance is also found to develop through figures of speech and rhetorical devices, including metaphors. Results show that facial expressions, pitch and other prosodic information are not always consciously taken in. Nevertheless, it is questioned whether such information can affect the ethos and pistis developed.