The problem of finding targeted medicine is a central problem in chemotherapy. From this point of view the ubiquitin-proteasome system is a highly promising object in the pharmaceutical approach. Proteasome plays a critical role in cellular protein degradation, cell cycle and apoptosis regulation.Proteasome inhibitors are substances blocking the actions of proteasome. Cancer cells are more sensitive to inhibition of the ubiquitin-proteasome system than normal cells. Therefore proteasome inhibitors have the potential to be successfully used in the cancer treatment.The study aimed to test various substances to identify possible proteasome inhibitors with the IncuCyteTM FLR image system and fluorometric microculture cytotoxicity assay.

This study has been conducted as a literary analysis of four chapter books for children in the early years of compulsory school: Magister Tutnäsa, Vilken fullträff, Astrakan, Sune och tjejhatarligan, and Alva och Dum-Julia. The aim has been to analyse four teacher characters from a gender perspective. The study has focused on the teachers? personal characteristics and whether these are typically female or male. Another aim has been to study how the character reinforces or runs against stereotyped gender patterns.

The main purpose of this thesis has been to address the problem connected with conservation ofspecific objects in historic buildings that have a protected building status. The immaterial demandsand environmental concerns of a place of cultural significance are discussed as opposed to the welladaptedsetting of a museum, with regard to long-term preservation. In an authentic interior of acertain era, large-scale individual treatments of the objects that define it and regulations forconservation-related reasons, may not be considered a worth-while effort, as it is often the integrityof the environment as a whole that has been declared as significant. To investigate the relationshipbetween object and its context, a case study has been conducted by examination of the propertycalled ?Curmans villor?, located in the seaside community called Lysekil.

The aim of the study is to explore the meaning of living with urinary incontinence caused by Spina Bifida, self-esteem, psychological well-beeing and expectations on treatment of urinary incontinence in 10 children and adolescents, 9-20 years old, as well as their parents perspective. The study was conducted through semi-structured interviewes as well as self-reports about self-esteem ("I think I am"; Ouvinen-Birgerstam, 1999) and psychological well-beeing (Beck Ungdomsskalor; Beck, Beck & Jolly, 2004). To examine the parents insight in their childrens situation and well-beeing parents proxy-reports was compared to their childrens self-reports. The results showed that psychological well-beeing and self-esteem of the children and adolescents in this study was comparable to normgroups, but that there was big individual differences. The parents proxy-reports are comparable to their childrens self-reports, but vary depending on the domain beeing estimated.

I och med den nya läroplanen för det obligatoriska skolväsendet, Lpo 94, breddades idrottsämnet och ämnet bytte namn från idrott till idrott och hälsa. Då hälsa är ett komplext och svårdefinierat begrepp var syftet med studien att undersöka tolkningsutrymmet vad gäller hälsa i kursplanen för idrott och hälsa. Studien inkluderade två olika undersökningar varav den ena avsåg en textanalys av samtliga läroplaner för grundskolan med inkluderande kursplaner för idrottsämnet. Detta för att belysa hur hälsosynen och tolkningsutrymmet har utvecklats över tid. Textanalysen kompletterades sedan med intervjuer av fyra behöriga idrottslärare för grundskolan i en kommun för att få inblick i hur yrkesverksamma tolkar hälsa utifrån kursplanen.

I detta examensarbete har jag främst försökt besvara två olika frågeställningar: Vad anser lärare på högstadiet om jämställdhet och jämställdhetsarbete i skolan? Och används några metoder för att jobba med jämställdhet och i så fall vilka?        För att besvara dessa frågor valde jag att skicka ut enkäter till 91 yrkesverksamma högstadielärare i Karlstads och Trollhättans kommun. Av dessa 91 enkäter fick jag in 30 svar vilka i sin tur utgör grunden för denna undersökning.  Av svaren framkom bland annat att 83% av pedagogerna ansåg sig dagligen eller flera gånger i veckan jobba medvetet med att främja jämställdheten i skolan och att 80% av lärarna har uppfattningen om att pedagoger på högstadiet i allmänhet tycker att jämställdhetsarbetet är viktigt. Men det framkom också att 85 % av pedagogerna tycker att skolan endast delvis uppfyller läroplanernas mål om jämställdhet och att 77.7 % anser att de har fått för lite utbildning inom området. 70% av pedagogerna i undersökningen kunde ge exempel på olika metoder som de använde sig av för att främja jämställdheten i skolan..

GE Healthcare operates in Uppsala (Sweden) and develops systems, equipments and medium to purify medical substances. Discussions with the local authority concerning planed far-reaching changes and upgrades of the biological process techniques for sewage management, aroused the question about revising the terms of permit for the activity. Therefore it seemed necessary to evaluate a newly installed biological process technique, which is the background of this thesis. The evaluated biological treatment process was built in 2003 and consists of a biological reactor filled with moving bed carriers with a high surface area for biological growth. At the time of the project the biological wastewater treatment plant consisted of a flow equalization facility and two following parallel biological processes; a biological reactor with moving bed carriers and a tower trickling filter.The aim of this thesis was to survey the function of the biological reactor with respect to the reduction of organic matter.

The object with this thesis is to evaluate which of the catch crops oil radish and white mustard in combination with establishment method, give the most effective nitrogen uptake. The main purpose of the catch crops is to reduce leakage of nitrogen. They are sown after the main crop and killed before the next crop. In Sweden the farmers gets subsidies to establish catch crops. The thesis is limited to the trail L3-9010 sited at HS- Malmöhus, Borgeby Gård, 237 91 Bjärred, Sweden, 2007. Only treatments with oil radish, white mustard and the reference treatments were studied.

It is common knowledge that our horses do occasionally hurt themselves and cause damage to their bodies. They also manage to do it in the most remarkable ways. The problem is not that they hurt themselves, because everybody does so from time to time. The problem is that they often experience difficulties with the healing of the wounds. The cause to that problem is the fact that they often lose a vast amount of tissue, the wound is more often than not extensively contaminated and the wound is often found a long time after the accident occurred.

The purpose of this study is to examine the situation of the school for boys 15-21 years of age lacking compulsory school attendance and is being located at five residential care units from the pedagogues? point of view. The study was conducted by interviewing four pedagogical leaders and two teachers. The results demonstrate that the boys can choose the subjects they study as well as the amount of time they spend on studying each week. The teachers include non-learning activities during their lessons.

AbstractThe purpose of this study has been to find out what attitude fifth graders have towards mathematics. This is done to get a better understanding of student?s feelings regarding about mathematics and what it is that makes mathematics fun or boring. My questions have been: What do the students think is fun, boring and difficult about mathematics? How do students think that a good mathematics teacher should be? Do the students see a difference in the mathematics teaching in easy compulsory school years?To find answers to my questions I have looked into prior research on students attitudes towards mathematics.

Biogas is a renewable energy produced through anaerobic digestion, which means that organic matter is degraded by microorganisms under anaerobic conditions. The produced biogas can then be used for cogeneration, electricity, heat or upgraded to vehicle gas. Eskilstuna Energy & Environment AB has four digesters at Ekeby water sewage treatment plant, Eskilstuna. One of the biogas reactor (RK4) is equipped with a jet-mixing system while the remaining digester uses top-mixing. The mixing system is an important parameter to achieve optimum operating conditions for the process regarding gas production and degree of digestion.

Title: From openness and presence to distance and control: to be medicated and to administrate from a patient and nurse perspective.Background: Within forensic psychiatric care the patients are admitted against their will, under heavy security with long term treatments. Self-care seems, based on scientific studies, to be dependent on what the nurses involved can provide. Emphasis should focus on a humane and respectful approach when the patient is exposed to coercive measures.Aim: From a patient and nurse perspective describe experiences of beeing medicated with and to administrate antipsychotic drugs within the psychiatric inpatient care.Method: Interviews with patients and nurses, which were analyzed using qualitative content analysis with an inductive approach.Results: Patients experience frustration over not beeing able to participate in or influence descisions made regarding their neuroleptic treatment. The neuroleptic treatment is described as a coercive measure and is characterized as an experience of losing control and independence. Nurses? experiences of administering antipsychotics were described as having to do what is needed for the long term benefit of patients? well-being.

The aim of the study was to investigate how teachers work with reading aloud. The aim also included examining their ideas about and motives for reading aloud. The study consisted of interviews with three teachers at the lower level of compulsory school along with observation of one of these teachers during a reading aloud session. The interviewed teachers work at three different schools in the same geographical area.The analytical tools chosen for the study were the theories of Rosenblatt. The three basic skills that Damber et al.

The aim of this study was to compare the effect between the drugs rituximab and infliximab in rheumatoid arthritis (RA). RA is an autoimmune disease that affects the peripheral joints and is associated with exacerbations. Various immune reactions in the body cause inflammation of the joints which further results in cartilage and bone damage. The diagnosis is made by the classification system "The 2010 American College of Rheumatology (ACR) / European league against rheumatism (EULAR) classification criteria for rheumatoid arthritis", which is an update of the older system called "The 1987 American College of Rheumatology classification criteria for RA". Approximately 0.5-1% of the population is developing the disease, but it varies slightly between different parts of the world.