Den insulinlika tillväxtfaktorn II (IGF II) är ett proteinhormon som reglerar cellers proliferation, tillväxt, migration, differentiering och överlevnad. Den utövar sin biologiska funktion via IGF I-receptorn. Dess tillgänglighet för bindning till IGF-1R regleras av en familj bestående av sex IGF-bindarproteiner (IGFBPs). IGF II kan också inducera mitos via en alternativt splitsad variant av insulinreceptorn (insulin receptor isoform A (IR-A)). De cirkulerande nivåerna av IGF II kontrolleras genom IGF II-receptorn, som saknar signalfunktion och är homolog med mannos-6- fosfatreceptorn. Tystad prägling av IGF II-genen är en återkommande observation vid en utvecklingsrubbning kallad Beckwith-Wiedemanns syndrom, vilket innefattar okontrollerad tillväxt och i många fall en njurtumör hos barn, Wilms? tumör. Tillväxthämning ses vid mutationer i genlocuset hos IGF II och den närliggande genen H19 vid en annan utvecklingsrubbning, Silver-Russells syndrom.

AbstractThe aim of this study is to highlight the professional?s perspectives and work with young girls who have eating disorder anorexia nervousa. We assume a social constructivist perspective where the professional?s interpretations and perspectives on the issue anorexia considered. The study is based on a qualitative analysis of interviews with seven professionals in the areas of work, social services, school counselor, school nurse, anorexia unit and child and adolescent psychiatry (BUP).From a thematic analysis of the interviews, three themes emerged.

SAMMANFATTNINGDilaterad kardiomyopati (DCM) är en ärftlig, primär hjärtmuskelsjukdom som är mycket vanligt förekommande hos dobermann. Sjukdomens förlopp har tre stadier. Det första stadiet innebär att sjukdomen föreligger men kan enbart påvisas vid histologisk undersökning av hjärtmuskelvävnad. Det prekliniska stadiet innebär att inga sjukdomstecken ses hos hunden, men förändringar, såsom hög förekomst av kammarextraslag och dilatation av vänster kammare, kan hittas med hjälp av elektrokardiografi (EKG) och ekokardiografi. I det overta (kliniska stadiet) uppvisar hunden sjukdomstecken som nedsatt arbetsförmåga, trötthet, hosta samt kachexi.

There are several possibilities for those with an eating disorder, who wishes to get treatment and recover to get help and support. But for those who are not ready to recover, there are not any help to receive. Pro-ana is a youth culture where individuals who want to achieve the anorectic ideal help and support each other. The purpose of this study was to describe and analyse the content and the need for the Pro-ana community on Internet, among young people with eating disorders. More specifically the aim was to find out how young Swedish people uses the Pro-ana communities on Internet.

Apart from recognizing and neutralizing threats, antibodies also have the ability to regulate immune responses against their specific antigen. IgG administered together with erythrocytes is well known to induce >99% suppression. This has been used to prevent haemolytic disease in new-borns since the 1960's, but the mechanism behind it is still not completely understood. The effect on the primary response is well established, but its influence on induction of immunological memory is still heavily debated. In this study adoptive cell transfer of splenocytes to irradiated mice was used to survey the effect IgG has on induction of immunological memory without disturbance from the primary IgG response.

Limb-sparing surgery aims to provide a functional pain free leg for the patient after removal of a local tumour in the leg. Reasons to perform limb-sparing instead of amputation can be arthrosis or hipdysplasia or other problems with the locomotor apparatus that makes the patient unsuitable for amputataion. Owner reluctance to amputate is another reason for limb-sparing. This master?s thesis is a case study of a dog with an osteosarcoma in its distal radius. The dog was treated by a limb-sparing method that uses the ipsilateral ulna as a vascularized roll-over autograft.

Aortic insufficiency is a very common valve problem in horses and most often affects older individuals, but nevertheless existent within younger ones. The root cause for aortic insufficiency can be varied, for example; endocarditis, ventricular septum defect or congenital valve disease but the most common are progressive valve degeneration or elite competition. Depending on the root cause, different changes can be observed on the aorta valves, but they do all have the same effect, the valves do not seal properly and blood leaks backwards. Many horses can, even with this deficiency, perform highly without any visible impacts and there is therefore no need to treat those subjects. Most often the symptoms arise at a later stage in life and they are, more often than none, put down for other reasons. In the occurrence of the clinical symptoms showing, treatment guideline is to inhibit these symptoms since the valve degeneration is presently irreversible.

ABSTRACTAim: The aim of this study is to chart the experiences of Swedish general psychiatric care on a Swedish University hospital from a relative?s point of view. The study focus on how they are meet, satisfaction with and participation in the care. The study is done as an improvement project.Methods: The study was conducted by performing semi-structured interviews with eight close relatives to patients on a general psychiatric ward. The interviews lasted for 20-40 minutes.Results: The result shows that relatives are satisfied with the way they are meet by the staff on the ward, that they appreciate staff that are open, down to earth and are inviting to form a good relationship.

Sexual dysfunctions concerning women with multiple sclerosis (MS) are common. Since the disease preferably affects young individuals when establishment of family occurs, the result of these problems have a great impact on the individual and her family. The purpose of this literature review is to throw light upon these problems and respond the questions if the nurse may be the right person to give sexual counselling and in which way this may be done. The theoretical framework was Antonovsky´s concept "sense of coherence". The result is presented in four themes: bodily aspects, social aspects, information/counselling, and practical implications for nurses.

 Bakgrund: I Sverige finns det cirka 160 000 personer som är drabbade av någon form av demenssjukdom och av dessa lider ca 60 % av Alzheimers sjukdom. Cirka en halv miljon svenskar beräknas vara anhöriga till någon som drabbats av Alzheimers sjukdom. Alzheimers kallas ibland för de anhörigas sjukdom, eftersom livssituationen förändras både för den drabbade och för de anhöriga. Syfte: Att beskriva anhörigas upplevelser av att vårda personer med Alzheimers sjukdom. Metod: Studien utfördes som en allmän litteraturstudie.

Mykotoxinet fumonisin B1 som förekommer i hela världen på framförallt majs, har visats ge upphov till flera olika toxiska effekter hos en mängd olika djurslag. De mest specifika är leukoencefalomalaci hos häst (ELEM) och lungödem hos gris (PPE), men även skador i lever, njurar och hjärt-kärlsystemet samt carcinogenicitet har observerats. Effekterna skiljer sig en hel del mellan olika djurslag, vilket den här uppsatsen syftade att hitta möjliga anledningar till. Dessutom var syftet att sammanställa information om fumonisins verkningsmekanismer ? både bekräftade och mer osäkra sådana, samt beskriva de toxiska effekterna hos olika djur och i olika organ och även ta upp diagnosticering, vilken dos som krävs för att orsaka sjukdom samt jämföra de rekommenderade gränsvärden som har satts upp för fumonisiner i foder med forskningsresultat.

Rapid economic development and urbanization has led to an improved standard of living for the Chinese people. Meanwhile, a series of environmental problems have also appeared and smog, in particular, has caused the Chinese people to realize how serious the situation is. Smog has seriously affected normal economic activities and people's everyday lives, resulting in financial losses, increased mortality and disease. How to handle the smog becomes particularly important. The purpose of this study is to describe and discuss the underlying causes of two sources of pollution, particulate matter and sulfur dioxide, as well as what drives individuals' and firms' environmentally destructive behavior.

The purpose of this project was to investigate if retention of polar compounds that are given to treat tuberculosis, diabetes, inflammatory bowel disease and childhood leukemia could be obtained with HILIC separation. By varying different parameters for different types of columns the compounds were analyzed with the aim of finding guidelines for future method optimizations. To perform these analyzes three different columns were tested ? ZIC-HILIC (silica-based with zwitterions), ZIC-pHILIC (polymer-based with zwitterions) and XBridge Amide (amide functions). The results were evaluated with selected quality measures.

This study was conducted at the University of Bath, UK, from September to December 2014 as part of an ongoing research project aimed at elucidating how the Grb10 gene might act as a mediator of long-term health effects (such as predisposition to obesity, diabetes, coronary heart disease and hypertension) caused by environmental factors during development. This phenomenon is known as developmental programming. The purpose of this thesis was not primarily to answer any of the broader questions posed by this research project at large since this would require much more data than is reasonable to acquire over the course of a few months, but rather to evaluate the methods used in this project and reveal whether they are working the way they are presumed to. In the research project, which employs mice with the Grb10 gene knocked out as well as wild-type control mice, a dietary restriction model is utilized during gestation, which is supposed to generate offspring with lower birth weight and subsequent detrimental health effects in adulthood. This is supposed to be achieved by restricting the protein content of the pregnant mothers? diet to 9 % (as opposed to the control diet of 20 %) throughout gestation.

Bakgrund: Förekomsten av diabetes typ 2 ökar ständigt och undervisning med patienter är betydelsefullt i sjuksköterskors omvårdnadsarbete. Undervisning kan dock upplevas mer blockerande än stödjande. Syfte: Att beskriva sjuksköterskors stöd i undervisningen angående förändring av kost- och motionsvanor hos patienter med diabetes typ 2. Metod: En litteraturstudie har gjorts baserad på åtta vetenskapliga artiklar. Resultat: Bemötande och identifiera behov; empati, respekt och engagemang samt att vara insatt i var patienter befinner sig i förändringsprocessen förbättrar möjligheterna att påverka.