Multiple Congenital Ocular Anomalities (MCOA) is a genetic disease that affects primarily Silver coloured horses of breeds such as the Rocky and Kentucky mountain horses. In these breeds the Silver dapple colour is very popular leading to an increase of affected horses. The major feature of the disease is ocular cysts of variable size. Large cysts also lead to a variety of secondary syndromes, for example retinal detachment. In previous studies the locus for MCOA has been mapped to an interval of 420 kb on equine chromosome six.

Background: As a part of a national health control program, Statens VeterinärmedicinskaAnstalt performs diagnostics to screen flocks for certain pathogens causing high mortality,morbidity and/or serious economical losses. There are several viruses in the programincluding IBDV (infectious bursal disease virus), IBV (infectious bronchitis virus) and NDV(Newcastle disease virus). Method: 96 serum samples were collected from different poultryflocks in Sweden and analyzed by ELISA, which are currently used in the health controlprogram as well as by a commercial prototype of a multiplex immunoassay manufactured byLuminex Corp., which is currently under evaluation at the United States Department ofAgriculture USDA. This 4-plex assay detects antibodies for the three above-mentionedviruses as well as antibodies of avian reovirus. In the context of this study the ELISAs run inroutine diagnostics as well as a REO ELISA were used as the standard for comparison.Result: The antibody concentration in serum from vaccinated chickens was high while theantibody concentration level in serum from not vaccinated chickens was low.

Background: As a part of a national health control program, Statens VeterinärmedicinskaAnstalt performs diagnostics to screen flocks for certain pathogens causing high mortality,morbidity and/or serious economical losses. There are several viruses in the programincluding IBDV (infectious bursal disease virus), IBV (infectious bronchitis virus) and NDV(Newcastle disease virus). Method: 96 serum samples were collected from different poultryflocks in Sweden and analyzed by ELISA, which are currently used in the health controlprogram as well as by a commercial prototype of a multiplex immunoassay manufactured byLuminex Corp., which is currently under evaluation at the United States Department ofAgriculture USDA. This 4-plex assay detects antibodies for the three above-mentionedviruses as well as antibodies of avian reovirus. In the context of this study the ELISAs run inroutine diagnostics as well as a REO ELISA were used as the standard for comparison.Result: The antibody concentration in serum from vaccinated chickens was high while theantibody concentration level in serum from not vaccinated chickens was low.

Feline infectious peritonitis (FIP) is a disease that can affect cats and is caused by a feline coronavirus (FCoV). FCoV is spread via the feacal-oral route and many cats are carriers of the virus. Despite that, very few of the carrier cats develop FIP. The explanation of this phenomenon is that the virus has to mutate to be able to cause FIP and in the majority of the carrier cats this mutation never occurs. FIP is very hard to diagnose because the symptoms are diffuse and a completely accurate diagnosis can almost exclusively be established during a postmortem necropsy.

Emerging infectious diseases poses a great future threat, not only to humans but also to domestic animals and wildlife. Even though the majority of these infections only cause minor health problems, the relatively recent emergence of HIV clearly illustrates that the next major human pandemic may surface at any time. Regardless of what the name indicates, most emerging human pathogens are not believed to be recently evolved, but to have existed previously in the natural environment. Most emerging pathogens are zoonotic, i.e. able to infect animals besides humans.

SammanfattningArbetets art: Uppsatsarbete omfattande 15 högskolepoäng C, inom ämnet ArbetsterapiSvensk titel:   Arbetsterapeuters användning av energibesparande metoder förpersoner med kronisk obstruktiv lungsjukdom ? En kvalitativ intervjustudie.Engelsk titel: Occupational therapists use of energy conservation methods for persons with chronic obstructive pulmonary disease.Handledare:   Margot FriskDatum:           2011-05-02Antal ord:      7993 ord Sammanfattning: Syftet med studien var att undersöka på vilket sätt och i vilket syfte arbetsterapeuter använder sig av energibesparande metoder som åtgärd för personer med kronisk obstruktiv lungsjukdom. Kronisk obstruktiv lungsjukdom (KOL) är en långsamt progredierande sjukdom som påverkar andningen negativt. Den påverkar även individens aktivitetsförmåga vilket leder till mindre självständighet i de vardagliga aktiviteterna. Arbetsterapi som profession är en resurs i rehabiliteringen av personer med KOL.

Bull terrier hereditary nephritis is caused by a mutation that leads to an inadequate synthesis of collagen type IV, which is an important component in the basement membranes. The inheritance of the mutation is autosomal dominant in bull terriers and progression to renal failure takes variable time, from several months to ten years. Proteinuria is the first clinical sign of the disease and the diagnosis is confirmed by transmission electron microscopy of renal tissue where typical ultrastructural changes in the glomerular basement membrane (GBM), thickening and multilaminar splitting are found. This study was performed in order to find out the occurrence of hereditary nephritis in bull terriers in Sweden through examination of urine samples and renal tissue and comparisons with how the disease is described in the literature. Urine samples from 76 Swedish bull terriers were collected and examined for proteinuria.

The purpose of this study was to describe the experiences of being a family caregiver for aperson with dementia. A further aim was the inclusion criteria and data collection methods inthe studies presented, and how this may have affected the results of the studies. The methodwas a descriptive literature study with qualitative approach. Data were collected throughdatabases Cinahl and Pubmed using the words: dementia, knowledge, information, support,caregivers, coping, spouses, experiences and family caregiving. Keywords were combined indifferent ways in order to refine the search.

The mountainous Central Asian and former Soviet country Tajikistan is the least advantaged country economically among the former Soviet Union states. Approximately 6.5 % of the land is arable in a country where roughly 80 % of the households typically own small numbers of sheep and goats. Management practices and animal husbandry in the villages such as uncontrolled breeding, mixing of animals on pastures favor transmission of infectious diseases. Brucellosis is a zoonotic bacterial disease caused by Brucella spp. The disease is endemic in Tajikistan. B.

The Bovine respiratory syncytial virus (BRSV) causes bronchiolitis and interstitial pneumonia, predominantly in calves, and is a major cause of bovine respiratory disease worldwide. In humans, BRSV is paralleled by the closely related Human respiratory syncytial virus (HRSV), an important cause of respiratory disease, most severe in infants.The clinical signs and pathology during RSV infection is caused, not only by the direct effects of viral replication, but also by the response of the host immune system. The immunopathology of RSV has long obfuscated our understanding of the disease, and development of effective treatment and vaccines will be very difficult until greater knowledge is gained.One of the components of the immune system that has come into focus in RSV research the last few years, is the Toll-like receptor 4 (TLR4). The TLR4 receptor is well known as the receptor that binds lipopolysaccaride (LPS), and initiates the host response to bacterial infection. Recently, it has been shown that the fusion protein of RSV also interacts with, and up-regulates the expression of, the TLR4 receptor.

This study was performed in order to investigate the difficulty in diagnosing retrobulbar disease with ultrasound. A retrospective study was accomplished to investigate the use of ultrasound in patients with suspected retrobulbar problems, and how often the examination is diagnostic. The computer based patient files, at the University of Agricultural Science in Uppsala, were searched for dogs with suspected retrobulbar disease. During 1999-01-01-2004-04-14, 14 patients fulfilling the search criteria were found. The patient records were studied, and the written reports from the ultrasound examinations were compared with the printed pictures from the examinations.

Sahlgrenska Academyat University of GothenburgDepartment of Internal Medicine and Clinical NutritionAbstractTitle: Cow?s milk and chronic constipation in children ? A systematic reviewAuthor: Sara Palm & Anna SvenssonSupervisor: Frode SlindeExaminer: Anna WinkvistProgramme: Dietician study programme, 180/240 ECTSType of paper: Examination paper, 15 hpDate: May 27, 2014Background: Chronic functional constipation is common among children. Up to a third of all who seek a paediatrician suffer from constipation and it is a widespread problem for children in many countries. Lately it has been discussed if cow?s milk can be a cause of the constipation and if it should be considered a delayed hypersensitivity.Objective: The aim of this systematic review is to examine whether there is scientific evidence to recommend a cow?s milk-free diet as a potential treatment in chronically constipated children.Search strategy: The literature searches were performed in the databases Pubmed, Scopus and the Cochrane library, using the search terms cow?s milk, constipation, milk proteins, dairy products, milk hypersensitivity, cow milk and cows milk between March 17th and April 4th 2014.Selection criteria: Randomized controlled trials measuring stool frequency in chronically constipated children on a cow?s milk-free diet were included.

White-Nose Syndrome, WNS, is an emerging fungal disease in the Northern American bat population causing mass mortality in infected hibernacula. Geomyces destructans is a newly discovered psychrophilic fungus causing WNS but the pathogenesis and epidemiology of the disease is not yet fully clarified. Geomyces destructans has been found in Europe but has not been a cause of mass mortality there. This study is the first investigation done to see if G. destructans is present in Sweden.

Sahlgrenska Academy at University of Gothenburg Department of Internal Medicine and Clinical NutritionAbstractTitle: Alpha-linolenic acid from flaxseed oil and effects on blood pressure ? A systematic reviewAuthor: Christine Hårdfelt och Liduina van SitterenSupervisor: Helen LindqvistExaminer: Anna WinkvistProgramme: Dietician study programme, 180/240 ECTSType of paper: Examination paper, 15 hpDate: April 9th, 2014Background: High blood pressure is strongly associated with an increased risk of developing cardiovascular disease, particularly stroke. ALA-fatty acids have previously been associated with decreased blood pressure. Flaxseed oil is very rich in these fatty acids and has also been highlighted as an affordable and sustainable source.Objective: To investigate whether ALA-fatty acids from flaxseed oil may affect blood pressure in people with high risk for cardiovascular disease.Search strategy: Two searches in PubMed and Scopus were performed. The sample was specified by using specific keywords.Selection criteria: The criteria for inclusion of studies required that flaxseed oil was compared with a control and that blood pressure was measured as an endpoint.

Celiac disease (CD) is an autoimmune disease, induced by an immune mediated reaction in the small intestine after ingestion of gluten and related prolamines. There is a strong genetic linkage and most important are the genes that encodes for HLA-DQ2 and HLA-DQ8. The European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) has developed new guidelines for investigation of CD in children and adolescents, which include genotyping for HLA-DQ2 and HLA-DQ8. Therefore, the clinical microbiological laboratory in Västmanland wants to introduce a method for analysis of these genes. Microarray is a newly developed method for determination of the alleles HLA-DQA1 and HLA-DQB1 that encodes for the ?- and ?-subunits of the HLA-molecules.