The prehospital management of patients with acute myocardial infarction (AMI)now includes 12-lead electrocardiogram transmission directly from the ambulance to hospital.If the ECG shows ST-elevated myocardial infarction the patient should be transported directlyto a hospital with capability for percutaneous coronary intervention (PCI).                                               Aim: The aim of this study was to describe how ambulance nurses experienced the prehospital management of patients with AMI who are transported by ambulance directly to hospital for PCI.                                                Method: Semi structured interviews were conducted with eight ambulance nurses. Data were analysed using qualitative content analysis. The categories that emerged were: Use ofcompetence, Responsibility and Insufficiency. Result: The result showed that the ambulance nurses felt secure when they cared for patients transported directly to PCI. The nurses assessed the patient and decided how he or she should be cared for.

Introduction The genetic skin disease epidermolytic ichtyosis is caused by mutations in either keratin gene 1 or 10 and leads to blisters and hyperkeratosis of the epidermis. At cellular level the disease is seen as aggregates in the keratin filaments. Since medicines are hard to investigate and produce mainly due to lack of reproducible model systems, there is no good treatment available for this disease today. In this article we describe how an in vitro model consisting of cells from a stable cell line transfected with expression plasmids to mimic patient cells, may be a possible alternative for screening compounds for therapies. The first step was to generate an expression plasmid required to complete the in vitro model.

På histopatologiska laboratoriet vid Länssjukhuset Ryhov i Jönköping är dehydreringsprocessen i dagsläget förlagd över natt. För upprätthållande av god kvalitet på diagnos med förbättrat provflöde och utnyttjande av instrumentens fulla kapacitet önskas att ett kortare dehydreringsprogram implementeras och förläggs dagtid. Syftet med denna studie var således att utvärdera ett kortare dehydreringsprogram för stansbiopsier från human hud och portio. Detta har gjorts utifrån cellmorfologiska bedömningsgrunder och bedömning av färgkvalité av rutinfärgning med Hematoxylin och Eosin samt specialfärgningarna polykrommetylenblått enligt Unna, Periodic acid-Schiff och Giemsa. Ett material om 87 biopsier från human hud samt portio dehydrerades fördelat över gällande rutinprogram samt utvärderat kortprogram.

The problem of finding targeted medicine is a central problem in chemotherapy. From this point of view the ubiquitin-proteasome system is a highly promising object in the pharmaceutical approach. Proteasome plays a critical role in cellular protein degradation, cell cycle and apoptosis regulation.Proteasome inhibitors are substances blocking the actions of proteasome. Cancer cells are more sensitive to inhibition of the ubiquitin-proteasome system than normal cells. Therefore proteasome inhibitors have the potential to be successfully used in the cancer treatment.The study aimed to test various substances to identify possible proteasome inhibitors with the IncuCyteTM FLR image system and fluorometric microculture cytotoxicity assay.

In this study, we have explored a new area called ?gamification? ? a word and concept that was first introduced on the Internet autumn 2010. Gamification concerns integrating game design, with emphasis on game mechanics and game dynamics, into non-gaming contexts ? such as marketing. At its basic definition, it concerns the process of transforming all kinds of activities into games.

Varför ökar antalet besök på folkbiblioteken medan antalet lån minskar? Syftet med den här undersökningen är att studera vad besökarna gör på Luleå folkbiblioteks huvudbibliotek och hur de betraktar sitt bibliotek. Frågeställningarna är: ? Vad gör besökarna på biblioteket förutom att låna böcker, tidningar och AV-medier? ? Hur betraktar besökarna på Luleå folkbibliotek sitt bibliotek? ? Vilka är det som besöker biblioteket? ? Hur är miljön på biblioteket och vilken inverkan har den på biblioteksbesökarna? ? Är biblioteket också en plats som lockar till sig andra besökare än de som söker det som förknippas med biblioteksverksamhet? För att kunna besvara frågeställningarna har en observationsundersökning och en enkätundersökning gjorts. I analysen har några begrepp från Bourdieu använts.

Promoters are genetic elements that facilitate the transcription of a gene and they have been found in front of non-coding RNA (ncRNA) genes in different organ-isms, e.g. the model plant Arabidopsis thaliana. A similar element, DUSE, has been found in front of ncRNAs in the social amoeba Dictyostelium discoideum and a part of this project has been to analyze the function of this putative promoter element through cloning and expression studies. A construct to analyze the func-tion of DUSE was successfully designed and introduced into D. discoideum but full expression studies were not finished because of shortage of time.

Promoters are genetic elements that facilitate the transcription of a gene and they have been found in front of non-coding RNA (ncRNA) genes in different organ-isms, e.g. the model plant Arabidopsis thaliana. A similar element, DUSE, has been found in front of ncRNAs in the social amoeba Dictyostelium discoideum and a part of this project has been to analyze the function of this putative promoter element through cloning and expression studies. A construct to analyze the func-tion of DUSE was successfully designed and introduced into D. discoideum but full expression studies were not finished because of shortage of time.

Promoters are genetic elements that facilitate the transcription of a gene and they have been found in front of non-coding RNA (ncRNA) genes in different organ-isms, e.g. the model plant Arabidopsis thaliana. A similar element, DUSE, has been found in front of ncRNAs in the social amoeba Dictyostelium discoideum and a part of this project has been to analyze the function of this putative promoter element through cloning and expression studies. A construct to analyze the func-tion of DUSE was successfully designed and introduced into D. discoideum but full expression studies were not finished because of shortage of time.

Today most dosages used in horse medicine are based on studies in adult horses. Since there are differences between adult and neonatal horses with respect to different pharmacological parameters this can cause problems when administring drugs to neonatal foals. Neonatal sepsis is a common cause of morbidity and mortality in foals and aggressive antibiotic treatment is needed immediately when sepsis is suspected. In Sweden the combination of trimethoprim/sulphadiazine and bensylpenicillin is often used as the initial treatment. When administering drugs, interactions can occur between the drugs and endogenous substances.

Kronisk exacerbativ uveit (ERU) är en av de vanligare ögonsjukdomarna hos häst och drabbar hästnäringen svårt. Det är idag accepterat att sjukdomen är immunologiskt medierad och syftet med denna litteraturstudie är att klargöra de immunologiska mekanismer som ligger bakom sjukdomsförloppet. Detta genom att utreda vad som inducerar uveit och hur återfall av uveit uppkommer samt de autoimmuna mekanismer som är aktiva vid sjukdomen. Grundbulten i ett friskt öga är dess upprätthållande av ett immunprivilegium då en inflammation skulle kunna förstöra strukturer som inte kan repareras igen. Om de barriärer som upprätthåller ögats immunstatus bryts tillåts immunförsvarceller nå ögats strukturer, något som observeras vid ERU.