The thesis presents an optimally designed kinematic structure for a new 6-DOF haptic devicebased on TAU configuration. The configuration of the TAU-2 proposed by Suleman Khan andKjell Andersson [1] was modified and its mobility was verified by using Grübler criterion tohave a 6 DOF. Analytical kinematic models for the inverse and forward kinematics weredeveloped for the haptic TAU configuration to determine a set of optimal design parameters.Kinematic performance indices such as volume of the workspace, kinematic isotropy and payload index, were defined based on the singular values of the Jacobian matrix. The Jacobianmatrix was scaled to homogenize the physical units. The Jacobian matrix dependent on theposition and orientation of the end-effector gives local isotropy and pay load index, so globaldesign indices were defined, which represent the performance of the mechanism in the wholeworkspace.

Matrix metalloproteinaser (MMPs) är en grupp proteolytiska enzymer som degraderar komponenter i vävnaders extracellulära matrix (ECM). Dessa proteiner spelar en viktig roll i många fysiologiska och patologiska processer. Enzymerna anses vara delaktiga vid olika typer av hjärtsjukdomar där de genom att utöva sin effekt påverkar sammansättningen hos ECM. Aktiviteten hos MMPs hämmas av TIMPs (tissue inhibitors of metalloproteinases) som är enzymernas specifika inhibitorer. Balans mellan nedbrytning och uppbyggnad av ECM är nödvändigt för att bibehålla hjärtvävnadens normala struktur och funktion.

The ability to detect protein-based biomarkers, which are linked to different diseases like colorectal cancer, is very important as a diagnostic tool. Usually complex biological samples like blood are studied which will contribute to different technical issues when performing an assay. The aim with the project is to optimize and develop the high throughput protein detection technique Proximity Extension Assay, PEA, into a 96-plex panel, in hopes of discovering an expression profile for colorectal cancer. PEA was developed by Olink Bioscience and allows specific proteins in a sample to be quantitatively transformed into nucleic acid sequences that are subsequently detected and quantified with real-time PCR. Two proximity probes containing oligonucleotide sequences bind pairwise to target protein and when brought in proximity, a DNA polymerase will extend a hybridization arm from one probe over to the second forming a double-stranded DNA sequence that can serve as a template in real-time PCR.

The cattle production in the world has been questioned in Sweden due to its negative impacts on the environment. The use of imported soya bean meal as a protein feed for Swedish cattle results in the cutting of rainforest and an extensive use of pesticides in the countries were the soya beans are produced. As a consequence, the environmental impacts caused by cattle production increases. A production of protein feeds in Sweden would decrease the transportations and the cutting of rainforest. For organic beef producers the possibility to produce home-grown protein feeds is important since organic protein feeds can be difficult to obtain in another way.

I den här uppsatsen beskrivs en ansats till att med hjälp av statistiska metoder förutse utfallet i förmögenhetsra?ttsliga dispositiva tvistemål. Logistiska- och multilogistiska regressionsmodeller skattades på data för 13299 tvistemål från 5 tingsrätter och användes  till att förutse utfallet för 1522 tvistemål från 3 andra tingsrätter.  Modellerna presterade bättre än slumpen vilket ger stöd för slutsatsen att man kan använda statistiska metoder för att förutse utfallet i denna typ av tvistemål..

The development of quantitative, real-time PCR (qPCR) combined with the mapping of the canine genome opens new possibilities in veterinary medicine. This method provides a quick and accurate quantification of the expression of a specific gene at a given point in time and thereby also information of how the gene expression for a certain protein is influenced by various conditions and diseases. One possible area of application is identifying bio markers for cancer. Recently the protein serglycin (the core protein of an intracellular proteoglycan) was found to act as a selective marker for the disease acute myeloid leukemia in humans (Niemann et al, 2007). Serglycin is produced by most hematopoietic cells, although mast cells account for the largest amount of serglycin.

The purpose of this thesis is to study how preschool teachers can reach the goal of the swedish educational plan to prevent traditional gender roles for children ages 3-6 through drama in education.This is answered by four hypothesis based on Judith Butler's queer theory, George Herbert Mead's social psychological theory and Gavin Bolton and Dotothy Heathcotes drama pedagogical theories. The hypotheses are tested against four teachers' examples of their work.The hypotheses areHypothesis 1: By using the expert's mantle and active observation in teacher-in-role indrama educational exercises, we can see how the children internalize the heterosexualmatrix and the outline of the internalized other.Hypothesis 2: By using the "mistakes" that occur when children repeat performativeacts that do not fit with the heterosexual matrix, these other possible behaviors can bestrengthenedHypothesis 3: Through drama exercises that are not normative teachers can widen theheterosexual matrixHypothesis 4: Through drama pedagogical methods like teacher-in-role teachers canprovide possibilities of other performative acts and the creation of a more tolerantinternalized other.The analysis show that the respondents work within all these hypotheses in different ways and thathypotheses 2 is the one with the weakest support in the interwievs. The examples are also weakregarding the use of Boltons drama pedagogical methods, but that there are a number of othermethods in use.Some of the conclusions are that more theoretical knowledge in the preschool drama pedagogics tocounteract traditional gender roles and patterns, as well as the drama of educational theory need tobe linked to queer and social psychology research. There is also no monitoring of the long term effects of the work..

This project investigated how elevation and vegetation type influences variation in plant litter phenolic content and protein precipitation capacity among and within common plant species for two different vegetation types, heath and meadow, in a subarctic ecosystem in the Abisko region of northern Sweden. As nutrient availability generally decreases with increasing elevation as a result of decreasing temperature, I hypothesised that phenolic content would increase with elevation and be higher on the heath than the meadow. To test this, the total phenolic content and protein precipitation capacity was estimated in leaf litter from 13 species in both heath and meadow vegetation across an elevational gradient ranging from 500 to 1000 meters above sea level (m.a.s.l.) in the study region. The results showed that elevation and vegetation type both had a strong impact on both variables. Total phenolic concentrations decreased with elevation for the meadow, and were greater for the heath than the meadow.

The objective of the present study was to evaluate distillers? dried grains with solubles (DDGS) as a protein source to rainbow trout (Oncorhynchus mykiss), by studying digestibility and growth measurements. One control diet, totally lacking DDGS, and three test diets were made containing 10 % (low), 31% (medium) and 51 % (high) DDGS respectively on dry matter (DM) basis. The control diet and the test diets were made to be as nutritionally equal as possible. Wheat bran was used to balance the fiber content of the diets.

Användningen av biomarkörer inom medicin är ett viktigt verktyg för att ställa diagnos och fatta terapetiska beslut. Surfaktant protein D (SP-D) har visat sig vara en lovande biomarkör för perifera lungsjukdomar på humansidan och har därför även börjat studeras inom veterinärmedicinen. Surfaktant protein D är ett relativt lungspecifikt protein och produceras främst i perifera delar av lungorna, f.f.a av claraceller i bronkioler och typ II pneumocyter i alveoler. Det fungerar som ett akutfasprotein med liknande egenskaper som kollektiner och är därför viktigt för medfödda immunförsvaret. Förutom detta har det också visat sig vara grundläggande för normala lunghomeostasen genom att utgöra en beståndsdel i surfaktant. Mekanismerna bakom dess funktion i lungan är dock inte helt klarlagda. Eftersom SP-D är så basalt för lungan påverkas det ofta kraftigt vid perifera lungskador.

Det kommer ständigt nya studier med olika hälsoråd angående kosten och fysiskaktivitet om hur vi ska undvika fetma, högt blodtryck samt hjärt- och kärlsjukdomar.Intresset av proteinets effekt på uppbyggnad av muskelmassa vid fysisk aktivitet harökat. Detta har medfört ett stort urval av olika drycker med proteintillskott påmarknaden, främst ur animaliskt ursprung.Syftet med detta examensarbete var att ta fram en vegetabilisk proteinberikadhavredryck som förväntas hjälpa kroppen vid återhämtning. Arbetet innebar att utvecklaett recept baserat på de Nordiska Näringsrekommendationer 2004 (NNR) med fokus påprotein, kolhydrater och fett. Delmålet var även att utesluta allergener. Dryckenbaserades på ett medelvärde från de fysiskt aktiva och äldre människors näringsbehov,detta för att bredda den tilltänkta dryckens målgrupp.Fyra smaksatta drycker framställdes med olika energiinnehåll utifrån två olikahavredrycker, en naturell och en kalciumberikad.

The purpose of this thesis is to study how preschool teachers can reach the goal of the swedish educational plan to prevent traditional gender roles for children ages 3-6 through drama in education.This is answered by four hypothesis based on Judith Butler's queer theory, George Herbert Mead's social psychological theory and Gavin Bolton and Dotothy Heathcotes drama pedagogical theories. The hypotheses are tested against four teachers' examples of their work.The hypotheses areHypothesis 1: By using the expert's mantle and active observation in teacher-in-role indrama educational exercises, we can see how the children internalize the heterosexualmatrix and the outline of the internalized other.Hypothesis 2: By using the "mistakes" that occur when children repeat performativeacts that do not fit with the heterosexual matrix, these other possible behaviors can bestrengthenedHypothesis 3: Through drama exercises that are not normative teachers can widen theheterosexual matrixHypothesis 4: Through drama pedagogical methods like teacher-in-role teachers canprovide possibilities of other performative acts and the creation of a more tolerantinternalized other.The analysis show that the respondents work within all these hypotheses in different ways and thathypotheses 2 is the one with the weakest support in the interwievs. The examples are also weakregarding the use of Boltons drama pedagogical methods, but that there are a number of othermethods in use.Some of the conclusions are that more theoretical knowledge in the preschool drama pedagogics tocounteract traditional gender roles and patterns, as well as the drama of educational theory need tobe linked to queer and social psychology research. There is also no monitoring of the long term effects of the work..

Horses are grazers with a digestive system that is adapted for a high fiber diet. Forage is a fiber rich feed that includes grass and legumes. A deficiency of forage and an excess of grains may cause gut disturbances and stereotypic behavior. The aim of this literature study was to summarize information on the horse?s capacity to consume forage-only diets with focus on the horse?s need of energy and protein.

Sahlgrenska Academy at University of GothenburgDepartment of Internal Medicine and Clinical Nutrition3AbstractTitle: How does isoflavones in combination with soy protein impact cholesterol levels in hypercholesterolemic postmenopausal women relative to milk protein?Author: Emma Edberg och Emma NilssonSupervisor: Lena HulthénExaminer: Anna WinkvistProgramme: Dietician stydy programme,180/240 hpType of paper: Examination paper, 15 hpDate: 2014-05-26Background: Hypercholesterolemia is a major risk factor for cardiovascular disease and the number one cause of death among women in Western countries. Declining levels of estrogen at menopause could be a contribution factor. Isoflavones is a vegetable substance, with structural and functional similarities to the human estrogen. This is a potential reason for possible cholesterol-lowering effects.

The coproduct, dried distillers grains + solubles (DDGS) from ethanol production based on wheat contains much rumen degradable protein and fiber with low digestibility. To compliment this quality in an effective way a grass silage low in protein and much digestible fiber is needed. The aim of the study was to investigate the effects of adjusting the crude-protein concentration and fiber quality of the silage when feeding DDGS and of varying the inclusion level of DDGS, when feeding the adjusted grass silage, on intake, milk yield and composition, faecal traits and feed efficiency. Four different total mixed rations were compared. The normal grass-clover silage had a crude protein content of 17,8 % and an NDF content of 46,2 % of dry matter. The adapted grass silage had a crude protein content of 14,6 % and an NDF content of 52,9 % of dry matter. The diets were formulated to have similar nutritional content except for A + 4 which had a higher content of rumen degradable crude protein and a lower concentration of NDF.