Sulforafan är en isothiocyanat-förening som finns i stora mängder i olika kålväxter. Sulforafan har setts ha en kemopreventiv inverkan bland annat genom att inducera fas II-enzymer styrda av transkriptionsfaktorn nuclear factor E2-related factor-2 (Nrf2). Nrf2 är mycket viktig i cellers skydd mor oxidativ- och elektrofil stress och inducerar uttrycket av många olika gener, bland annat olika tranportproteiner. Breast cancer resistance protein (BCRP) är en av transportörerna som tros induceras av Nrf2. BCRP finns i stora mängder i lakterande juvervävnad men också i många andra vävnader där den transporterar läkemedel ut ur cellerna.

Breast cancer is the most common tumor disease among women in Sweden. About 7000persons, having a median age of 65, are diagnosed each year with this disease. Withmammography screening, breast cancer can be detected in an early stage which improves theoverall survival (OS). 20-30 % of the breast cancer tumors are overexpressing humanepidermal growth factor receptor 2 (HER2), which is a protein that stimulates cell proliferation.Trastuzumab (Herceptin®) is a humanised monoclonal antibody that targets the HER2-proteinand prevent the signals for cell proliferation.Trastuzumab has earlier been used for treatment of metastatic breast cancer. In the year of 2007trastuzumab was approved for adjuvant treatment of patients who has been medicated withsurgery and/or radiation.The aim of this study was to investigate the effects of adjuvant treatment with trastuzumab inHER2-positive breast cancer patients.

Introduction: Breast pain, mastalgia, is a common problem for many women. The pain can cause so much concern that the woman seeks help in health care. The cause of concern is often that that the pain may be due to breast cancer. Women with mastalgia are referred for mammography to investigate the cause of the pain. Experience says that the mammography is mostly normal.Aim: The aim of the study was to get an overall picture of the results of the mammograms performed on Mammography SU / Sahlgrenska in 2011.

When facing the fact that high yielding dairy cows has an increasing energy requirements, the practice of adding lipid supplements such as concentrates rich in palm oil and/or palm oil industry by-products become more common. Palm oil containing high levels of C16:0 causes high levels of free fatty acids (FFA) which are linked to larger milk fat globules (MFG) which affect the reaction of lipolysis resulting in rancid flavour and processing problems. Instead of using palm oil, rapeseed oil rich in C18:1 C18:2 can be used. In order to evaluate the effect of added C18:0 and C16:0 on milk lipolysis, 30 Swedish Red lactating dairy cows including 15 multiparous (MP) and 15 primiparous (PP) cows were randomly divided in three groups resulting in 3 10 cow-groups (5 PP and 5 MP cows per group) and fed one out of three concentrate mixtures: control (C), a standard concentrate mixture with no fat added; palmitate (P) as C plus the addition of palmitate methyl ester (10 % in DM basis); and stearate (St) as C plus the addition of stearate methyl ester (10 % in DM basis). Milk yield was registered, and milk samples were collected and analysed for milk composition, FFA content and size of MFG.

Swedish goats are mainly held for cheese production and therefore, both milk quality and composition are of great importance for dairymen. Today, only few data exists on milk composition from Swedish dairy goats and the casein content is still unknown. One way to reduce the work load for goat farmers and increase animal welfare can be to keep goats and kids together for longer periods. The aims of this study were to investigate how milk yield and composition were affected when kids suckled their dams during 8 weeks, and to measure the casein content on farm level by a mid-infrared spectroscopy method, previously calibrated for goat milk. Lactating goats were kept in two different MIX- systems where the dams are both suckled and milked.

Breast cancer is the most common tumor disease among women in Sweden. About 7000persons, having a median age of 65, are diagnosed each year with this disease. Withmammography screening, breast cancer can be detected in an early stage which improves theoverall survival (OS). 20-30 % of the breast cancer tumors are overexpressing humanepidermal growth factor receptor 2 (HER2), which is a protein that stimulates cell proliferation.Trastuzumab (Herceptin®) is a humanised monoclonal antibody that targets the HER2-proteinand prevent the signals for cell proliferation.Trastuzumab has earlier been used for treatment of metastatic breast cancer. In the year of 2007trastuzumab was approved for adjuvant treatment of patients who has been medicated withsurgery and/or radiation.The aim of this study was to investigate the effects of adjuvant treatment with trastuzumab inHER2-positive breast cancer patients.

Milk yield levels in dairy cows are influenced by many factors such as nutrition, breed, health status, management and environment. This study was conducted among small scale farmers in Zambia, where the climate can be dry for up to six months per year and cause a lack of green pasture for livestock and on-farm produced feed. The purpose of this study was to identify management factors that can influence milk yield at small scale dairy farms in Zambia, and present advice that could improve productivity, without the need of expensive investments. The study included semi-structured questionnaires presented to the farmers (n=29) including questions about cattle management and milk production. Testing of somatic cell count (SCC) with DCC (DeLaval Cell Counter) from herd milk samples (n=56) and observation of housing and animal body condition on-farm was also made.

The taste of the dairy product is probably the main factor determining consumer?s dairy products choice. Consequently it is of great importance that the product tastes good and as expected every time. Off-flavors in milk can be caused by for example oxidation of the milk fat. Since copper is a prooxidant, a high copper content in the milk can cause oxidation.

Breast cancer is the most common form of cancer affecting women. The treatment of breast cancer may lead to forcing the woman to remove her breast. The breast is a symbol of femininity and sexuality for many women. The purpose of this literature-based study is to describe women's experiences of altered body image and sexuality after mastectomy. This may provide a better understanding of the nurse in responding to these breast cancer patients.

In a time when milk producing farm businesses face decline in profitability it is of great importance to examine how the situation can be improved. This thesis is a study off efficiency in milk producing farm businesses represented by Swedish, Dutch and German farms. The aim of this study is to investigate whether any differences exist between companies in these countries. Moreover, the study includes a mapping of a number of factors that determine how efficient milk production can be managed. This mapping is based on a literature review on prior efficiency studies followed by qualitative interviews with milk production advisors as well as a questionnaire sent out to dairy farmers in Sweden.

Background: Breast cancer is one of the most common cancer diseases among women worldwide. Breast cancer brings fear into many womens? life. It is a threat against life, but also to the psychological health, self-esteem and the female identity. Aim: The aim of this literature review was to describe newly breast cancer patient?s perception of information provided by healthcare personnel.

Body image in women with breastcancerBreast cancer is the second most common form of cancer in Sweden today. To get a breast cancer diagnose can be a traumatic experience for many women. It´s difficult to forsee how these women are going to control their situation. When a breast has to be removed because of cancer, the women has to adjust to changes in both physical and phychological aspects. The aim of this study was to elucidate body image in women with breast cancer after a mastectomy.

Background                      There are different types of treatments for breast cancer, and these may be of surgical and non-surgical art. These treatments produce different side effects that can cause both physical and mental harm to the woman. The breast cancer can change the women's body image and relationships to their families. The women manage their lives in different ways depending on which culture they belong to. Aim                                    The aim of the study was to elucidate women?s experience of her body and the altered body in relation to breast cancer treatment.Method                              The method used was a literature review based on scientifically articles to overview the field of breast cancer.

Background: Breast cancer is one of the most common types of cancer in the world and it usually affects elderly women. However, there are between 600-700 cases per year in Sweden where women under the age of 45 are diagnosed. Removal of the breast or part of the breast, hair loss, fatigue and nausea as a result of the breast cancer treatment has an emotional and physical impact on the women?s lifeworld. The nurse should build a relationship with the women to identify and meet their needs. Aim: To describe younger women?s experiences of getting a breast cancer diagnosis and life afterwards.Method: Four biographical books were analyzed to match the aim of the study.Result: The findings were that the women experience similar thoughts and feelings when it comes to living with a cancer diagnosis.

The pig is unique in the way that it gives birth to a large number of newborns in each litter. Because of this the sow has developed a special behaviour during suckling to ensure that not only a part of the litter gets all the milk. Milk is only available during milk letdown. The piglets have to massage the udder for a long time before letdown and the more piglets at the udder the sooner the milk comes. The sow has developed a special grunting pattern to let the piglets know when she is ready for suckling and to signal milk letdown. Our aim with this study was to investigate if sows have individual grunting patterns repeated over time. We also wanted to know if sows with a more distinct grunting pattern have better growth in their litters.