Alternative splicing is a process that partly rejects the common definition of a gene ? that one gene codes for one specific protein. By variable combination of coding regions (exons) and exclusion of non-coding regions (introns), formation of several different mRNA-transcripts, and consequently several different proteins, can derive from the same gene. Alternative splicing is an important condition for the development of complex life forms, but it is also a highly sensitive process and inaccurate splicing is the cause of approximately 15 % of mutations that cause genetic diseases. This article presents four genes, BRCA1, BRCA2, ER? and ER?, and inaccurate splicing of these genes increases the risk of developing cancer, particularly breast cancer and ovarian cancer.

Bakgrund: Övervikt och fetma är en global epidemi. Fetma kan orsakas av arv, miljö och beteendemässiga faktorer. Övervikt kanleda till flera följdsjukdomar. Viktminskning kan ge ökad livskvalité pch psykiskt välbefinnande. Ur ett hälsoekonomiskt perspektiv är det av vikt att det hälsofrämjande arbetet startar tidigt i barndomen.

Background; Gynecological cancer is a common term for cancer in the female genitals and 2013 there were about 2800 women in Sweden that was diagnosed. This form of cancer and the treatment that is used, affects the sexuality and also the fertility of the women.Aim; The purpose with the essay was to illustrate the experience of the sexuality after the treatment of gynecological cancer.Method; The method used in the essay was a systematic translation of different literature. Of all the articles used there were eight that was qualitative, two quantitative and one was a combination of both methods. The analytic process was accomplish with the support of the Friberg (2006) analytic method.Results; The analysis resulted in two categories; Physical changes after the treatment and the treatments impact on the sexuality of the women. The physical changes that occurred because of the treatment was recurring and it showed that it was primarily surgery that hurt the woman body.

Background: In Sweden around 6500 women suffer each year from breast cancer and during lifetime every tenth women is affected. Mastectomy (removal of part of or the whole breast) is carried out mostly in purpose to remove malign tumours or in prophylactic purpose. The breast can be rebuilt through breast reconstruction. Method: The result analysis was based on nine articles. A Manifest content analysis was used and data from the articles where divided into themes and patterns, on the basis of these categories were created.

For a woman who has been diagnosed with breast cancer, there can be many negative things that effects her life. It is a great shock that changes her life and can include a sense of lost femininity and a decreased sexual desire which can be both physical and psychological. The basis of this literature review is from 17 scientific articles which evaluate the changes in cancer patient's body image and sexuality during their illness and treatment. This study illustrates patient's experience of the nursing and difficulties which obstructs the nurse from talking about sexuality whit the patient. The study also showed that the patient had a desire to discuss these sexuality issues with a nurse..

Cancer is one of the most common diseases and it affects not only adults but also many adolecents and children every year. Those who are affected of disease face many challenges that will affect their lives. The aim of this literature review was to illuminate adolecents experience of cancer and how it affects them in their daily living. The result showed that the adolecents experience many physical and mental side-effects from disease and treatment. They expressed the need of information, support and understanding from their families, friends, school and care givers.

Sulforafan är en isothiocyanat-förening som finns i stora mängder i olika kålväxter. Sulforafan har setts ha en kemopreventiv inverkan bland annat genom att inducera fas II-enzymer styrda av transkriptionsfaktorn nuclear factor E2-related factor-2 (Nrf2). Nrf2 är mycket viktig i cellers skydd mor oxidativ- och elektrofil stress och inducerar uttrycket av många olika gener, bland annat olika tranportproteiner. Breast cancer resistance protein (BCRP) är en av transportörerna som tros induceras av Nrf2. BCRP finns i stora mängder i lakterande juvervävnad men också i många andra vävnader där den transporterar läkemedel ut ur cellerna.

Featured adjuvant chemotherapy treatment in women with breast cancer can lead to pain. The aim of this study was to explore, the variety of perceptions and impact of adjuvantchemotherapy-induced pain in daily life, of some women newly diagnosed with breast cancer.Inclusion criteria were participating in an ongoing stress management projectand chemotherapy of (anthracycline/taxan) in doses of 75mg² or more. Exclusioncriteria were inability to understand and communicate in Swedish and mentalillness. After ethical approval of the sub study in September 2010, women wereconsecutively included through oral and written request. Phenomenologicalapproach was used in the eight interviews and data analysis.

Aim: To describe perceptions about written and verbal information regarding diet and physical activity in women with breast cancer and to study possible differences between ages and perception. Method: A cross-sectional study was conducted and consisted of 57 women with breast cancer stages I-III who started adjuvant chemotherapy within a year (2007-2008). A questionnaire, regarding their perceptions about the written and verbal information they had received about diet and physical activity, was responded to three months following treatment completion. Between 67-93 % of the participants responded to the questions. The answers was analyzed with descriptive statistics and Mann Whitney U-test.

Cancer is one of the most feared diseases in veterinary medicine today, and the incidence is higher than ever due to the fact that our companion animals live longer then they did ten to twenty years ago. Cancer is also one of the most common causes of mortality in older companion animals. This literature review will be about two of the currently most common form of cancer treatment of companion animals in Swedish animal hospitals, chemotherapy and radiation therapy. There will also be a section of general nursing care for cancer patients. The section of chemotherapy will describe the indications for choosing chemotherapy, the way to administrate chemotherapeutic drugs, describe specific chemotherapeutic drugs, potential side effects of chemotherapy, and how to handle and store chemotherapeutic drugs safely. The section of radiation therapy will describe the current devices for delivering radiation therapy, describe the indications for choosing radiation therapy and describe potential side effects that radiation therapy may cause.

This study describes how the women lived with breast cancer. The purpose with this study was to describe the womens' view on the disease and the understanding they hade on the social support they were depended on. The method was a study of literature with article reviews according to Polit et al., 2001. As theoretical frame of reference we choose Carnevalis model, Everyday life -Functional state of health. The result showed that the following four groups were formed: Support, positive and negative support off nursing staff and significant others.

Endast en procent av alla bröstcancerdrabbade per år är män. Det är ett område som är eftersatt i forskningen och dåligt uppmärksammat av både vården och samhället. Syftet med studien var att undersöka mäns upplevelser av att drabbas av bröstcancer. Den metod som användes var i form av en litteraturstudie med kvalitativ ansats. Urvalet bestod av sju vetenskapliga artiklar som fokuserade på mäns upplevelser av att leva med bröstcancer som sedan granskades utifrån Polit och Becks (2010) kriterier.

Narratives about life-changing events like cancer have become more common in today?s society. The purpose of the present study was to investigate whether gender patterns in society can also be found in pathographies about cancer, and further to investigate how gender is expressed in these cancer related narratives. Questions were posed on characteristics of the autobiographical cancer narratives, how gender is constructed by the authors of these narratives, and what these narratives say about gender structures? liability to change in the individuals affected by this disease.

Background: Globally, one percent of all people diagnosed with cancer are children. Childhood cancer often requires long and tough treatments. When a child is diagnosed with cancer it also affects the family and the relatives. Aim: The aim of this study was to describe the nurse?s role in the care and treatment of children with cancer.

Aim: To describe perceptions about written and verbal information regarding diet and physical activity in women with breast cancer and to study possible differences between ages and perception. Method: A cross-sectional study was conducted and consisted of 57 women with breast cancer stages I-III who started adjuvant chemotherapy within a year (2007-2008). A questionnaire, regarding their perceptions about the written and verbal information they had received about diet and physical activity, was responded to three months following treatment completion. Between 67-93 % of the participants responded to the questions. The answers was analyzed with descriptive statistics and Mann Whitney U-test.