This literature study aims to examine the existence of cancer stem cells in breast cancer. The cancer stem cell theory states that there is a hierarchical organization within a tumour, in which a small subpopulation of the cells can initiate new tumours and maintain tumour growth whilst the bulk of the tumour cannot. These tumour initiating cells have shown to possess many characteristics similar to those of adult stem cells, which is why they are often referred to as cancer stem cells. Both cell types have the capacity of asymmetric division and have shown to possess mechanisms of resistance to both apoptosis and cancer drugs. The cancer stem cell theory elucidates many biological aspects such as the heterogeneity of tumours and the relapse of many cancers after what appeared to be successful treatments.

Sleep has a substantial effect on health status where good sleeping habits proves positive on learning. The aim of the present study was to map the views and perceptions of sleep and its effects on health and school performance on 12-year olds. The goal is to visualize these views to give teachers the possibility to better plan the education in concordance with the students? abilities. The study is based on qualitative semi-structured interviews where 12 students aged 12 have partaken.

SammanfattningBakgrund: Deep brain stimulation (DBS) i nucleus ventralis intermedius i thalamus (VIM) eller caudala zona incerta (cZi) ger goda effekter på tremorsymptomen för patienter med essentiell tremor. Patienterna som behandlats med DBS kan få bieffekter som i vissa fall leder till talpåverkan, så kallad stimuleringsinducerad dysartri. Huruvida det finns risk för bieffekter som drabbar röstens funktion hos patienter med essentiell tremor saknas studier kring men man vet att grundsjukdomen kan påverka rösten akustiskt samt att vissa patienter utvecklar rösttremor. Att drabbas av en bieffekt efter DBS kan ha en inverkan på hur patienten subjektivt upplever resultatet av behandlingen.   Mål: Att undersöka om patienter med essentiell tremor som genomgått DBS subjektivt upplever någon form av röst- eller talbesvär jämfört med en frisk, ålders- och könsmatchad kontrollgrupp. Metod: I studien deltog sammanlagt 42 deltagare varav 21 tillhörde en patientgrupp med essentiell tremor som genomgått DBS i cZi och de övriga 21 tillhörde en frisk, ålders- och könsmatchad kontrollgrupp. Deltagarna i de båda grupperna fick fylla i två formulär, RHI som berör röstens funktion och SOFT som berör talets funktion.

Oxytocin is today widely spoken of as a "feel good" hormone. Recent research has increased interest in the hormone and its role in social and sexual interactions, as well as its importance for complex behavioral patterns. There is evidence that oxytocin is released during physical contact and is said to suppress anxiety and stress. In animals and humans, oxytocin, which is a neuropeptide and likewise a hormone, is necessary for parturition and lactation. Synthesis of oxytocin occurs in brain neurons and in specific organs involved in reproduction.

Syftet med denna kvalitativa studie var att beskriva personer med traumatisk hjärnskadas erfarenheter av fritidsaktiviteter. Den undersökta gruppen bestod av sju personer i åldern 26 ? 54 år. Tid efter traumat var minst två år. Datainsamlingen genomfördes genom individuella semistrukturerade intervjuer och analyserades utifrån kvalitativ innehållsanalys enligt Graneheim och Lundman (2004) och resulterade i tre kategorier: ? Personliga begränsningar vid utförandet av fritidsaktiviteter?, ? Förändring av utförandet eller annat val av fritidsaktiviteter?, ?Miljöns påverkan av utförandet av fritidsaktiviteter?.

The main objective of this study is to divide a number of colorectal cancer cases into subgroups based on their molecular features using cluster analysis. The data used is supplied by a research group at Pathology, the Department of Medical Biosciences, Umeå University, and consists, after some preparation, of 455 observations which is a larger data set than many similar studies. The molecular variables that the clustering is based on are CIMP (CpG Island Methylator Phenotype), MSI (Micro Satellite Instability), BRAF- and KRAS-mutations. These are categorical variables and consequently the clustering method used is PAM (Partitioning Around Medoids) which is particularly useful with data on diverse variable level. The final analysis results in four subgroups that are represented by different combinations of attributes on the aforementioned variables.

The aim of the literature review was to illuminate the importance of nutritional management to patients who have sustained a traumatic brain injury (TBI) and describe nurses responsibility and meaningful function in the nutritional support. TBI patients tend to be associated with hypermetabolism and hypercatabolism, resulting in negative nitrogen balances. The results reveal increased energy expenditure and assessments of needs energy requirements at the TBI patients. This study determining the route of feeding: enteral versus parenteral nutrition. Furthermore describes complications associated with enteral feeding.

The purpose of my study is that I have examined children age 4 years and 5 years of their perceptions about the body's internal organs, and if they know where they are sitting in the body, and what their perception of organ systems. I have compared their perceptions and thoughts about the internal organs, to see their similarities and differences it is about childrens perceptions and thoughts dependent if they is 4-respektive 5- years old.The results that I got from my examination was that they showed me a big variety by their earlier perception about the organs. Some had knowledge of the name, some had of the function and some of the place of the organ brain, heart, lungs, stomach, liver and intestines. All these knowledge about the organs was a variety on and you could see similarities and differences in the different ages. One example about a different is that it was a four year old child that could the name of the stomach and the stomach function while there was three five years old children that could the brains name, function and place..

Today, some kind of laboratory results is required for around 70% of the diagnostics and follow-ups for diseases. In many of the cases the time from sampling to a result is very critical. Therefore the discussion of how to improve this situation has begun. For many analyses serum has been the routine choice for a long time but now it is disputed. After blood collection in a serum tube it is essential to wait 30-60 minutes before centrifugation and analysis of the sample, a long time for someone in an acute state.

BCI (Brain Computer Interface) för användning i spel har börjat dyka upp på konsument-marknaden. Dessa använder ofta EEG för att mäta spelarnas avslappningsnivåer och den spelare som lyckas nå högsta meditativa tillstånd samlar poäng. I detta arbete undersöks huruvida det går att använda BCI för mer direkt kontroll av en specifik spelmekanik i kombination med konventionella spelkontroller. För undersökningen har två versioner av ett spel skapats med avsikten att mäta skillnaden i hjärnaktiviteten hos spelare som bara spelar, jämfört med spelare som aktivt försöker åstadkomma ett specifikt sinnestillstånd för att direkt kontrollera en funktion i spelet. På grund av studiens begränsade omfattning kunde inga definitiva slutsatser dras men det finns indikationer på att MindWave, som var utrustningen som användes i denna studie, inte är lämplig som direkt kontrollmetod tillsammans med andra kontroller.

Stroke is a widespread disease in Sweden. Nurses play a central part for those who suffer from a stroke irrespective of where in the care chain they meet. To be able to meet the patients? need of care the nurse must understand his/her lifeworld. Each and every patient is unique and the experience of being struck by a stroke depends on personality and life situation.

Serum thymidine kinase 1 (TK1) activity is used as a tumor marker in disease monitoring in veterinary and human medicine. TK1, an intracellular enzyme, is involved in a salvage pathway of DNA precursor synthesis. TK1 is used in DNA precursor production by catalyzing the transfer of the gamma-phosphate-group from a phosphate-donor to the 5?- hydroxyl-group of thymidine forming thymidine-monophosphate. Nucleoside monophosphosphates are finally converted into thymidine-triphosphates. TK1 activity significantly rises in the G1 and the S phase of the cell cycle.

Breast cancer is the most common tumor disease among women in Sweden. About 7000persons, having a median age of 65, are diagnosed each year with this disease. Withmammography screening, breast cancer can be detected in an early stage which improves theoverall survival (OS). 20-30 % of the breast cancer tumors are overexpressing humanepidermal growth factor receptor 2 (HER2), which is a protein that stimulates cell proliferation.Trastuzumab (Herceptin®) is a humanised monoclonal antibody that targets the HER2-proteinand prevent the signals for cell proliferation.Trastuzumab has earlier been used for treatment of metastatic breast cancer. In the year of 2007trastuzumab was approved for adjuvant treatment of patients who has been medicated withsurgery and/or radiation.The aim of this study was to investigate the effects of adjuvant treatment with trastuzumab inHER2-positive breast cancer patients.

A historical study of intervention for aphasia may provide information on how speech and language pathologists work with people with aphasia. Aphasia is seen as an umbrella term for symptoms of language disorders caused by aquired brain injury. The overall aim of the present study was to describe and analyze the development of intervention for aphasia during the periods 1990-1999 and 2000-2010.The study was conducted by analysis of 83 medical records from two hospitals in Sweden during a period of 20 years. These decades were compared to each other and yo current litteraturein search for differences and trends in aphasia intervention.The Results of the present study revealed that intervention mainly focused on recovering the linguistic ability in both the 1990s and 2000s. Intervention and literature focusing on communication seem to increase during the 2000s.

This is a thesis about The Eight Circuit Model, a modern mind map developed for the purpose of illumination and enlighenment by Dr. Timothy Leary in the 1970s. Later, authors such as Robert Anton Wilson and Antero Alli elaborated upon the idea to make it more wholesome and compatible with other ideas expressing the same basic principle. In short, it is an intellectual abstraction of the evolution of consciousness through a series of eight stages, which Leary called Circuits. By looking at the brain as an evolving bio-computer, with thoughts working as software, upgrading itself through neurological imprints, Learys created a Hero's Journey for the modern age.The thesis tries to analyze this idea, as it is presented in Robert Anton Wilsons Prometheus Rising, through the lens of the discourse category ?Western Esoterism.? A hard-to-define subject but described as ?the dialectic of the hidden and the revealed in the field of religion.?.