Alternative splicing is a process that partly rejects the common definition of a gene ? that one gene codes for one specific protein. By variable combination of coding regions (exons) and exclusion of non-coding regions (introns), formation of several different mRNA-transcripts, and consequently several different proteins, can derive from the same gene. Alternative splicing is an important condition for the development of complex life forms, but it is also a highly sensitive process and inaccurate splicing is the cause of approximately 15 % of mutations that cause genetic diseases. This article presents four genes, BRCA1, BRCA2, ER? and ER?, and inaccurate splicing of these genes increases the risk of developing cancer, particularly breast cancer and ovarian cancer.

The complexity of the mast cell is becoming more prominent. From being the cell recognized just to contribute to allergic inflammation it is now also associated with wound healing, protection against tumor growth and in recognition and defense against a wide range of pathogens. The location of the mast cell in the barrier between the external and internal environment of the body enables the cell to quickly respond to invading bacteria, virus and parasites. Diarrhea due to Escherichia coli infection, listeriosis, toxoplasmosis, Newcastle disease and bovine respiratory syncytial virus are examples of mast cell activating diseases that can affect animals in, as well as outside, the agricultural sector. Additionally, ticks and tick-borne diseases are of concern.

AbstractThe signification of the eyesight for children?s development and learning- how do pedagogues support and stimulate children with defective vision in their development and learning in pre-school?These issues are based on my purpose of the field survey investigations, where I have interviewed three pedagogues and also performed an observation.My main conclusion and results describe that the vision is the high-powered engine in children?s development and learning. It also tells us that those around the children are very important for optimum development and learning, especially when it comes to supporting and stimulating children with defective vision in their necessities. Our other senses are a compensation to make it easier for children with defective visions in their lives. But all our senses are equally important for children with defective vision as they are for seeing children in their development and learning with their whole body in pre-school.Keywords:Eyesight, children with defective vision, development and learning in pre-school, pedagogues, pedagogical support and stimulation.

The Swedish group contribution rules entails that group contribution is only allowed when the parent company owns more than 90 percent in a company. To be able to deduct group contribution some conditions has to be fulfilled. One condition is that the receiver of the contribution shall not be a resident of a foreign state. The question that arises is whether group contribution with deductibility is consistent with the non-discrimination clause. In some group contribution situations several tax conventions can be applicable.

BackgroundMigraine is a comprehensive endemic disease who is affecting both women and men, but with higher prevalence among women because of hormonal factors. Risk factors for the disease are female gender, hereditariness, depression and socio-economic factors. Migraine can be triggered by factors like stress, menstruation, irregular routines for sleep and unbalanced meals and diet. Migraine is a condition that causes a big suffering for the affected individuals.AimThe aim of this study was to describe individuals' experiences of how migraine is affecting the daily life, out of the aspects like working life, family life and social life.MethodA literature overview was maintained, and eight qualitative studies and two quantitative studies between the years 2003- 2014 were analyzed.ResultsThe analysis of the articles lead to one main theme; "Guilt, compensating and restrictions" and seven subthemes "Not being able to perform their best", "Met with incomprehension", "Not being able to take care of home and children", "Not enough", "Avoiding activities", "Always be prepared" and "Living with restrictions".ConclusionMigraine is affecting the daily life among these individuals in a great extent. The disease makes it hard to perform well at work.

A clean and affordable energy source for cooking is deficient in developing countries. People rely on fuels that contribute to environmental, social and health problems.Biogas is an alternative energy source and an increased investment in small-scale biogas production can in several developing countries be found. Several projects have started to use the technology in developing countries because of the benefits with biogas. Some cases in the establishment of biogas plants have succeeded and some have not. The study is a literature review supplemented by two field studies.

SyfteSyftet med denna studie var att klarlägga om det finns något samband mellan anterior knälaxitet, mätt med KT-1000, och "funktion i sport och fritid" respektive "knärelaterad livskvalitet", enligt Knee injury and Osteoarthrits Outcome Score (KOOS), 6-8 månader efter en främre korsbandsrekonstruktion. Ett annat syfte var att studera om det föreligger någon könsskillnad avseende dessa parametrar.MetodDenna undersökning är baserad på ett prospektivt insamlat registermaterial från Svenska korsbandsregistret samt från Capio Artro Clinic´s IT-register avseende patienter som genomgått främre korsbandsrekonstruktion med hamstringsgraft.Urvalet av patienterna (18-35 år) gjordes konsekutivt under åren 2010-2011 bland de ortopedkirurger som gjort flest antal operationer under denna period, vilket kom att omfatta 427 patienter. Baserat på inklusions- och exklusionskriterier kvarstod 100 patienter. En powerberäkning visade på behov av 58 patienter, 29 män och 29 kvinnor. En jämn fördelning, mellan män och kvinnor gjordes genom lottning.

A clean and affordable energy source for cooking is deficient in developing countries. People rely on fuels that contribute to environmental, social and health problems.Biogas is an alternative energy source and an increased investment in small-scale biogas production can in several developing countries be found. Several projects have started to use the technology in developing countries because of the benefits with biogas. Some cases in the establishment of biogas plants have succeeded and some have not. The study is a literature review supplemented by two field studies.

The cost of forwarding corresponds to about one tenth of the forestry industries raw material cost. This gives a motive to do good follow-ups to get a good overview of the forwarding distance and, thus, enable improvements. Follow-ups are also justified by the possibility to make more accurate calculations of the harvesting costs, if better estimations of forwarding distance are achieved. Today (2009) Stora Enso has GPS and vehicle-computers in most of their forwarders. These are used mainly for the forwarder to follow the tracks of the harvester and for the planning leader to see how the forwarder has been driving within the stand.

Denna rapport beskriver en produktutvecklingsprocess som behandlar utvecklandet av ett textilt material som isolerar och skyddar. Det textila materialet ska fungera till ett kylande fodral utan att förstöra dess funktion och behöver därför uppfylla en speciell kravspecifikation. Materialet ska isolera mot kroppsvärme, vara stabilt, skyddande och slitstarkt. Dubbelväv valdes tidigt i arbetet då det är ett enkelt sätt att kunna påverka det textila materialets egenskaper i form av material- och konstruktionsval, i en betydligt större utsträckning än i en enkelsidig väv. För att utveckla ett material med de efterfrågade egenskaperna har tester utförs och den metod som har använts är hypotesprövning.

Today, many veterinary hospitals offer rehabilitation as a service. We think that this is an interesting subject and therefore we want to find out what rehabilitation methods that are available in Sweden for dogs and horses. We want to give animal nurses and other persons who have animals as an occupation an survey that shortly describes how the methods are performed, what physical effect they have in the body and to give examples in what conditions they are used. To find out what rehabilitation methods that are available we sent out two different questionnaires, one to hospitals/clinics for small animals and one to hospitals/clinics for horses and other companies that works with rehabilitation of horses. The information about the methods described in our project we have found in literature and on the Internet.

This two years master?s thesis in Library and Information Science examines book reviews and articles aboutbooks and authorship in media directed to children between the ages of 8 and 14. The aim is to increase knowledgeof children?s reading choices and view of reading. This is motivated by the decrease in literacy and sparetime reading among Swedish children and adolescents.

A clean and affordable energy source for cooking is deficient in developing countries. People rely on fuels that contribute to environmental, social and health problems.Biogas is an alternative energy source and an increased investment in small-scale biogas production can in several developing countries be found. Several projects have started to use the technology in developing countries because of the benefits with biogas. Some cases in the establishment of biogas plants have succeeded and some have not. The study is a literature review supplemented by two field studies.

It is essential to reuse- and recycles residues to decrease the amount of deposit materials and reach sustainable energy use. Two ways to work towards this is to recycle wood ashes to the forest as nutrient compensation and extract biogas from combustion of biomass.The aim with this study was to decide whether wood ashes that been used for biogas upgrading with accelerated carbonation also can be used as a nutrient compensation in the woods according to recommendations from the Swedish Forest Agency (Skogsstyrelsen).The ashes that were used in this study came from Johan Andersson who works at JTI in Uppsala, who also treated the ashes with biogas. The ashes have, in both untreated and treated condition, been analyzed in this study according to contents of elements, leaching properties, hardening properties and contents of crystalline phases, to evaluate what impact carbonation with biogas has on the ashes.The accelerated carbonation led to hardening of the ash, and decreased amount of CaO- and increased amount of CaCO3. The CO2-uptake also entails a dilution of the elements, and the content of nutrients and trace elements decreases. However the results show an indication of an uptake of S from the biogas to the ash, since the dilution had a smaller impact on S than the rest of the elements.

Background: In Sweden and Norway planned home birth is not included in the health care system. In Denmark women with expected low risk birth have the right to choose home birth. Registrations of home births in the Nordic countries are not completed and women?s experiences of planned home birth in Scandinavian context are not earlier described.Objective: The aim of this study was to describe women?s experiences of planned home birth in the Scandinavian countries.Design: Inductive content analysis. Fifty-three Scandinavian women who have experienced planned home birth have replied an open question in a questionnaire.