Background: Type 2 diabetes is a disease which causes vascular damage, stroke and premature death.Oxidative stress may play a role in the development of insulin resistance and diabetes. Selenium is amineral involved in the protection against oxidative stress, and has been thought to be favorable in theprevention of the disease. However, this has changed since trials observed positive correlationsbetween high selenium levels and incidence of type 2 diabetes.Objective: To examine the studies that investigates seleniums effect on the incidence of typ 2 diabetesSearch strategy: Searches have been done in PubMed and Scopus.Selection criteria: Included studies were human studies in English/Swedish with RCT or cohortdesign with the aim to investigate the correlation between selenium and incidence of type 2 diabetes.Excluded studies were studies whose aim was to investigate the role of selenium in patients withexisting diabetes. Studies regarding pregnant women, animals or children and with in vitro design werealso excluded. Of the studies found in Scopus where MeSH terms were available, the ones who did notinclude relevant terms were excluded.Data collection and analysis: Studies were collected according to the aforementioned criteria.

Horses are made to eat mainly roughage and it is essential for optimal health to offer them an appropriate amount of roughage with good hygienic and nutritional qualities. To produce good hay at the right time and be able to keep the hygienic quality until next summer is a problem. This has the effect that horse owners today choose haylage and silage to a larger extent. Science in this area is scarce, i.e. if the change from hay to silage has any effect on the horse.

En undersökning över hur ordet "ansvar" använts i svensk politik 1991-2013 och den förändring ordet genomgått i avsende på argumentativ funktionalitet under Fredrik Reinfeldts tid som statsminister..

Exocrine pancreatic insufficiency is a hereditary disease that in Sweden is especially common in German shepherds. The Swedish German shepherd club has currently no plan of action for decreasing disease prevalence in the breed. The purpose of this study was to review existing literature about the disease and also to perform an inventory of the disease in the Swedish dog population. Special focus was laid on the German shepherd breed. The inventory was later compared to an unpublished inventory of the disease with data from the Swedish University of Agricultural Sciences from 1997. During the period 2002-06-01 to 2007-09-26 (ca 64 months) 2961 blood samples were analyzed for cTLI. 274 samples were positive (cTLI .

Twitching is frequently used in horse management because of its sedating and pain-relieving effects. In this study, the effects on the horse?s nervous system by twitching were investigated by thermography of the skin temperature. The temperature is regulated by the sympathetic nervous system through postganglionic sfincters at the capillaries of the skin. The effects on the endocrine activity have also been studied by the measuring of ACTH and cortisol in blood plasma.

Syfte: Syftet med denna ?versiktsartikel ?r att unders?ka det vetenskapliga underlaget kring om ett intag av saffran kan f?rb?ttra HbA1c eller fasteglukos hos vuxna personer ? 18 ?r diagnostiserade med Diabetes Mellitus typ 2, j?mf?rt med placebo. Metod: Litteraturs?kningen genomf?rdes i databaserna PubMed och Scopus. S?kningen gjordes den 240323 och innfattade ord som "saffron?,? crocus?, "diabetes mellitus, type 2" och ?random*?. Artikelselektionen utf?rdes systematiskt med hj?lp av en avgr?nsad fr?gest?llning samt inklusions- och exklusionkriterier, d?r inklusionskriterier var RCT-studier, gjorda p? vuxna personer diagnosticerade med Diabetes Mellitus typ 2 d?r interventionen skulle f? supplementering av saffran, och kontrollen skulle f? placebo.

The aim of this study was to determine which type of fluid to use in trauma care to improve patient survival. The method used was a systematic review, where a total of 18 studies were reviewed and 13 included in the results. The inclusion criteria used in this study were Randomized controlled trial, or studies relevant for the purpose, written in English and published during the last ten years. The studies were identified in the PubMed data base. The results showed that in trauma with hypovolaemia, colloid infusion has a better effect than infusion of crystalloid fluid on blood pressure and colloid infusion reduced the body's cascade systems in a beneficial way. Colloid infusion administered to head injury patients lowered their intracranial pressure more than crystalloid infusion.

Pyometra (chronic purulent uterine inflammation) is a common disease in middle-aged and older intact bitches. The disease most frequently occurs in metoestrus and previous research studies have shown that both hormones and bacteria are involved in the development of the disease. Analysis of the blood levels of prostaglandin metabolite 15-keto-13,14-dihydro-PGF2? (PG-metabolite) has previously been shown to be clinically useful in the differentiation of canine uterine diseases such as pyometra and mucometra. The PG-metabolite concentration has also been correlated to severity in pyometra as determined by hospitalisation length. The purpose of the present study was to investigate if blood levels of PG-metabolite can differentiate uterine diseases such as pyometra from other diseases in female dogs.

Tissue factor (TF), a 47 kDa glycoprotein, is the initiator of the extrinsic pathway of blood coagulation and consequently of the upmost importance when damage to blood vessel occurs. The source of TF in circulation has been investigated. However, the source of TF is still not clear. One theory is that platelets express and increases the expression of TF after stimulation and the aim of our report was to investigate whether platelets really are a source for TF in circulation.Using specific primers for TF mRNA, platelets in plasma from healthy volunteers and from patients suffering from cardiac infarction were analyzed by using real-time polymerase chain reaction (PCR). Gel electrophoresis was performed after amplification of TF mRNA to verify the results.The samples were negative for TF when using real-time PCR and the few positive all had cycle threshold (Ct) values above 35.

Celiac disease (CD) is an autoimmune disease, induced by an immune mediated reaction in the small intestine after ingestion of gluten and related prolamines. There is a strong genetic linkage and most important are the genes that encodes for HLA-DQ2 and HLA-DQ8. The European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) has developed new guidelines for investigation of CD in children and adolescents, which include genotyping for HLA-DQ2 and HLA-DQ8. Therefore, the clinical microbiological laboratory in Västmanland wants to introduce a method for analysis of these genes. Microarray is a newly developed method for determination of the alleles HLA-DQA1 and HLA-DQB1 that encodes for the ?- and ?-subunits of the HLA-molecules.

The aim of this study was to investigate the intraoperative surgical stress response in dogs undergoing ovariohysterectomy and to compare acepromazine and medetomidine as premedications. 15 dogs diagnosed with pyometra were used in this study. Blood pressure and heart rate were used as parameters to measure surgical stress response. The surgery was divided into four phases. Phase 0 was the period 10 minutes before the skin incision, phase 1 was skin incision and opening of abdomen, phase 2 was manipulation of uterine horns, ligation and transection of mesovarium and phase 3 was ligation of cervix, removal of organs and closing the abdomen. The results showed that phase 2 was the most intense phase of surgical stress, regardless of which premedication the dogs received. When acepromazine and medetomidine were compared the results showed that within phase 3, all dogs that were given medetomidine had higher blood pressure compared to dogs that were given acepromazine. The dogs that were given acepromazine had higher heart rate than the dogs that were given medetomidine in phase 0, phase 2 and phase 3. .

People live longer. There is a growing need to increase the knowledge of aging and of the need among the elderly for medical care in the near future. As a step towards meeting this need, a survey among the elderly in Skåne is made by the division of Geriatric Medicine in Malmö University Hospital. This survey is called Gott åldrande i Skåne, GÅS. A frequent decease among the elderly is Mild Cognitive Impairment (MCI).

Clinical signs of hypocalcaemia in dairy cows are easily recognized, and a rapid response to treatment generally confirms the diagnosis in the field. However, clinical signs of other disorders in cows, such as toxemia, calving paralysis, or muscoskeletal injury, may mimic those associated with hypocalcaemia. Therefore, making a diagnosis of hypocalcaemia on the basis of clinical signs alone may be difficult. In ambulatory veterinary practices, cow-side tests are useful to make the diagnosis and prognosis easier. Kruuse?s Kalcium Test is a cow-side test based on the principle that calcium ions are necessary for coagulation of blood, and that chelation with EDTA prevent coagulation.

Celiac disease (CD) is an autoimmune disease, induced by an immune mediated reaction in the small intestine after ingestion of gluten and related prolamines. There is a strong genetic linkage and most important are the genes that encodes for HLA-DQ2 and HLA-DQ8. The European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) has developed new guidelines for investigation of CD in children and adolescents, which include genotyping for HLA-DQ2 and HLA-DQ8. Therefore, the clinical microbiological laboratory in Västmanland wants to introduce a method for analysis of these genes. Microarray is a newly developed method for determination of the alleles HLA-DQA1 and HLA-DQB1 that encodes for the ?- and ?-subunits of the HLA-molecules.

Platelets are important for the healing of damaged blood vessels since they have an importantpart to play in the coagulation process. At the same time, the blood must be kept fluid and notcoagulate at the wrong time. Therefore there are factors that effect the aggregation of plateletsin a positive or a negative way.Previous investigations have shown that platelets during stirring conditions produce reactiveoxygen species (ROS) that weaken the inhibiting effect of nitric oxides (NO) on platelets andthat the drug Dexamethasone (Dex) can reduce the ROS-production.The aim of this project was to investigate if glucocorticoids, in this case Dexamethasone,could restore the inhibiting effect of NO on platelets and if there was any decrease in ROS-production.The result of the ROS-measurements showed a great variance and it was difficult to draw anyconclusions from them, but a clear decrease in ROS, as previous reported, was not shown. In the aggregation experiments the inhibiting effect of NO was observed through the drug S-nitroso-N-acetylpenicillamine (SNAP), a NO-donator.From the aggregation experiments, the result seemed to be that SNAP during longerincubation time lost its inhibiting effect, probably because the cells become desensitized.With superoxid dismutase (SOD), the effect of SNAP increased, both in the experiment withlonger and shorter incubation times. Dex seemed to reinforce the aggregation in relation toboth SOD and SNAP.