Clopidogrel is an antiplatelet substance that prevents blood coagulation in the arteries. It is an inactive pro drug that becomes activated after first-pass metabolism by the liver. The active metabolite of clopidogrel is 2-oxoclopidogrel, which is unstable therefore pharmacokinetic data is obtained by measuring the inactive metabolite clopidogrel acid in plasma. Clopidogrel is taken orally in tablet form. The aim of this project was to develop a LC-MS/MS method for quantification of clopidogrel and its metabolite in plasma. The method has been developed by optimizing the sample preparation.

Eight healthy 3-day-old foals were given repeated injections of trimethoprim-sulfadiazine intravenously for 3 days, at a dosage of 15 mg/kg bodyweight (2,5 mg trimethoprim and 12,5 mg sulfadiazine). Blood samples were collected prior to each administration and for the following 24 hours after last administration. Serum concentrations of trimethoprim and sulfadiazine were measured and the pharmacokinetics for the substances were studied. The elimination half time (t½) and clearance (ClB) for trimethoprim and sulfadiazine for the foals did not diverge from adult horses. According to these data it is possible to assume that the same dose interval and dose can be used for foals as for adult horses.

Eight healthy 3-day-old foals were given repeated injections of trimethoprim-sulfadiazine intravenously for 3 days, at a dosage of 15 mg/kg bodyweight (2,5 mg trimethoprim and 12,5 mg sulfadiazine). Blood samples were collected prior to each administration and for the following 24 hours after last administration. Serum concentrations of trimethoprim and sulfadiazine were measured and the pharmacokinetics for the substances were studied. The elimination half time (t½) and clearance (ClB) for trimethoprim and sulfadiazine for the foals did not diverge from adult horses. According to these data it is possible to assume that the same dose interval and dose can be used for foals as for adult horses.

This report is about the development of a prototype of a mobile application and a web application that will help diabetes patients in their own treatment and ease diabetes nurses work with their diabetes patients. The mobile application is a digital version of a diabetes diary used by the Örebro County Council primary care to ease in diabetes treatments. The report also covers tests with users which were conducted on potential users to get some sort of feedback from groups other than customer and colleagues. Tests with users showed that there was an interest in a mobile application and it was a highly appreciated project. The web application ease diabetes nurses in their work with their diabetes patients in the way that the web application can display graphs of the patient's blood glucose level. .

Inledning: Distriktssköterskor har ett stort ansvar gällande blodtrycksmätning samt uppföljning av patienter med risk för hypertoni eller som behandlas för hypertoni inom primärvården. Blodtrycksmätning är en undersökningsmetod som förutsätter att den utförs korrekt med hänsyn till felkällor och rätt förfarande för att mätvärdet ska kunna tolkas rätt. Det finns ett flertal olika riktlinjer för hur standardiserad blodtrycksmätning bör utföras. Att arbeta hälsofrämjande är grundläggande i distriktssköterskors förhållningssätt och samtal kring livsstilsåtgärder är en viktig del i samband med behandling och förbyggande av förhöjt blodtryck. Syfte: Syftet med studien är att kartlägga hur blodtrycksmätning går till vid besöket hos distriktssköterskan samt vilka aspekter som tas upp i samtalet i samband med besöket.

Eight healthy 3-day-old foals were given repeated injections of trimethoprim-sulfadiazine intravenously for 3 days, at a dosage of 15 mg/kg bodyweight (2,5 mg trimethoprim and 12,5 mg sulfadiazine). Blood samples were collected prior to each administration and for the following 24 hours after last administration. Serum concentrations of trimethoprim and sulfadiazine were measured and the pharmacokinetics for the substances were studied. The elimination half time (t½) and clearance (ClB) for trimethoprim and sulfadiazine for the foals did not diverge from adult horses. According to these data it is possible to assume that the same dose interval and dose can be used for foals as for adult horses.

After I heard that two deadly accidents in farming 2003 were created by work with cattle, I got the idea of writing this degree project. So far there are not too many reports written about safety for the worker nor the animal. Therefore it will fit in with a report about safe handling of free stalled cattle. The Swedish Board of Agriculture would also like to do an information material about outside stalled cattle with this degree project as a background. The collecting of material was made by visiting farmers. The goal was to visit 15 ? 20 herds and when this is being written 19 herds have been visited.

The purpose of this study was to find possible explanations to why the studied herd had an increased incidence of abomasal displacements. The incidence of abomasal displacement in the herd was three times higher than the incidence of an average Swedish herd. The cows in this study were fed a total mixed ration. The different parameters studied were: energy content in food, nutritional content in food, body condition scoring, concomitant other diseases, and blood parameters of glucose, fructosamine, cholesterol, insulin, betahydroxybutyrat and free fatty acids. The author?s suggestions to decrease the problems are to decrease the energy content in the TMR to lower the cows? body condition scores in the dry period and changing the content in the TMR to increase the amount of NDF and adding structure in the form of chopped straw.

AbstractThe aim is to find out the teachers´ different point of views regarding what and why it´s important to teach children about the human body and in what way educationists can teach this knowledge. Seven teachers are asked, through qualitative interviews, about their point of views on teaching the human body in pre-school.The teachers don`t seem to reflect upon the subject, which shows that a development of knowledge needs within the area.Fist of all the children´s spontaneous questions direct what the educationists talk about with the children. The most frequently mentioned questions are about the circulation of the blood and the digestion organs. The teachers think it´s important that the children get knowledge about the human body in order to get a better opinion of their own bodies and themselves. It´s also important because this is the basis of other kind of knowledge, for instance the knowledge about animals..

AbstractMy purpose of this essay was to discover three- and four-year-olds comprehension of their internal body and then compare the result between their ages. I have used the same methods in both essays, semi-qualitative interviews. It is structured interviews with space for following questions. My formulations of the questions were: Do the children have a comprehension of their internal structure of the body? Do the children have a comprehension of organs and organ systems? Is there any difference between the ages?Their comprehensions I have categorized in four categories and I have seen age related differences in their comprehensions.

Many scientists agree that phytoestrogens could have an effect on the reproduction of an animal. The question is now why and what mechanisms that play an important role. This paper has been focusing on the estrus behavior of gilts by use of a behavioral study. Some of the gilts were given additional feed with the phytoestrogen genistein which commonly occurs in the feed as a part of soybean products. Blood samples were collected and analyzed for progesterone and estradiol concentrations.

SUMMARYThis work consists of a review of the medical records of 142 horses that visited the Equine dermatology clinic, at the University Animal Hospital, UDS, at Ultuna, Uppsala, Sweden, between January 2007 and June 2010. The study answers certain main questions like clinical signs responsible for the visit, the most common diagnoses, their diagnostic procedures, treatment modalities and finally, the outcome of treatment.Among 50 diagnoses, four were predominant followed by additional 46 diagnoses, each presenting by few or, in many cases, only one horse. The most common dermatological problem diagnosed was Equine Sarcoid representing 18,3 % of the cases (26/142), which probably reflects the initiation of a Sarcoid treatment-trial in 2007, that resulted in an accumulation of sarcoid horses in the clinic .The second most common diagnosis was Atopy 12 % (17/142) followed by Allergy with skin affection 9,2 % (13/142) and Acute superficial pyodermia 4,9 % (7/142). If the horses were divided into diagnostic groups, the majority (34,5 %) belonged to HA5 group, (Immunological skin diseases), followed by group HA4, (Infectious and inflammatory conditions of the skin) (22,5 %) and HA6, (Neoplasia) (21,8 %). Traumatic skin injuries represented only 2,1 % of the cases, compared to 80 % of horses in the Agria insurance statistics for veterinary care.The most common clinical sign and reasons for veterinary consultation was pruritus (35,9 %), suspected sarcoids (17,6 %), alopecia (12,7 %), nodules (12 %), seborrea, scaling and crusts (9,2 %) and excoriations (5,6 %), respectively, followed by a scattered number of more uncommon symtoms.The diagnostic methods most frequently applied were cytology and biopsy, used in 41,5 % and 36,6 % of the cases, respectively.

The purpose of this study was to describe how adolescents aged 12-18 years with inflammatory bowel disease experience their illness and what coping strategies they use to manage their illness and improve their wellbeing. The method used was a descriptive literature study, and the result of the study included 15 scientific articles. Our results showed that IBD affected the adolescent?s everyday life and social life with friends, family and activities. The adolescents also reported that they experienced a feeling of vulnerability, altered body image and that they saw themselves as different from healthy subjects.

The virus-mediated disease Rift Valley fever (RVF) was discovered during an outbreak in Kenya in the 1930s. Since then it has spread to most parts of Sub-Saharan Africa, and in the last decades several outbreaks have caused economic and health issues in Africa, Yemen and Saudi-Arabia. The disease mainly affects domestic livestock, causing abortions, but is also a zoonosis. To be able to control the spread of the disease it is important with surveillance for better knowledge about the distribution and virus circulation even in inter-epidemic/epizootic periods. The human population is growing, and people and their livestock constantly move closer to areas with wild animals which act as reservoirs for different viruses. Also, humans and their animals often get within reach for arthropod vectors, hosting or carrying viruses.

Bakgrund: I dag har 220 miljoner människor diabetes världen över och 90 % av dessa har typ 2 diabetes. Sjukdomen föregås alltid av en insulinresistens och eftersom den har en koppling till oxidativ stress är en teori att spårämnet selen kan spela en viktig roll. Det är känt att selen har antioxidativa effekter i kroppen och tidigare djurstudier har visat att selen skulle kunna härma insulinets effekter samt öka insulinkänsligheten.Syfte: Att ta reda på om selen kan skydda mot utvecklingen av typ 2 diabetes. De frågeställningar som användes var om selensupplementering, selenintag via kosten eller selenstatus i blod kan påverka risken att utveckla typ 2 diabetes hos friska individer.Sökväg: Datainsamlingen genomfördes i den medicinska databasen PubMed med sökorden ?selenium AND diabetes mellitus type 2?.