Duchenne Muscular Dystrophy (DMD) is a hereditary X-linked fatal disease that affects 1 in 3500 male births. It is the most common kind of muscular dystrophy in children and leads to death in the late teens or early 20s for many patients. The mdx mouse is a model of DMD that can be used to investigate experimental therapies. Overexpression of a glycosyltransferase, CT GalNAc, in mdx mice has been demonstrated to prevent the development of muscular dystrophy. Overexpression of another glycosyltransferase, LARGE, is currently being investigated as a treatment for another group of muscular dystrophies, the dystroglycanopathies. In this study, we overexpressed LARGE in mdx mice in order to investigate its effect on the development of muscular dystrophy.

This essay is a study that takes interest in technical and technological change essential to philosophy of science. What is shown is the importance of an active attitude towards this change, by the articulation of the question: Does technical development lead to new ontological questions for science? - and by the answer that such questions do appear.It is clear that passive assumptions in this matter might prohibit science in the proceeding search for truth.By examples of ways in which technical development helps and challenges science, it is concluded that scrutiny of the relationship between technical development and ontological suppositions and hypotheses within science is well motivated..

Tovesson. R 2012: Orientering av liv och död under mellanneolitikum. Irland, Orkneyöarna och södra England under perioden ca 4000 f.kr ? 2000 f.kr.The orientation of life and death- Ireland, Orkney, and Southern England during c 4000-2000 BC.Magisteruppsats i arkeologi. Linnéuniversitetet Kalmar Vt.

AbstractBackground: When an acute illness or trauma occurs, life becomes disorganised and shattered for the critically ill person and his/her family members. The family members are confronted with thoughts about life and death which can cause stress and anxiety. How the family members cope with the crisis is individual and depending on personality and earlier experiences. Aim: The purpose of this literary review was to illustrate the family members´ experiences when dealing with a critically ill family member. Method: A literary review was made based on fifteen qualitative and quantitative scientific articles and a literary book.

Background: Patients with borderline personality disorder represent a large group in healthcare who are struggling with painful emotions in life. Caring should be based on strengthening health processes by focusing on the patients, but research made by the patient's perspective has shown that this population rather felt that their health processes was counteracted, than promoted. The patients felt that the nurses displayed a negative attitude towards them. Attitudes are defined as a system of values, emotions and actions towards others. Aim: the purpose of this study was to highlight the attitudes and experiences of nurses towards caring for people with borderline personality disorder  Methods: A study on the literature based on nine scientific papers was performed. The articles have been analyzed, systematically coded and compiled into a new unit. Results: This study shows that nurses have an overall negative attitude towards patients with borderline personality disorder.

Chronic obstructive pulmonary disease (COPD) is a chronic lung disease. The disease is the fourth leading cause of death and more than 5 percent of the adult population worldwide is affected.The aim of this study was to investigate the association between periodontitis and COPD.Search for material for the literature review was done in the medical database PubMed where the keywords were: "Chronic obstructive pulmonary disease" and "Periodontal health or periodontal disease". The result is based on twelve studies that were extracted and analyzed. The studies have investigated pocket depth, attachment loss, plaque index, bleeding on probing and bone loss. Ten studies compared a COPD group with a healthy control group, one study compared two COPD groups and one study examined a COPD group and a group with other lung diseases.Most studies found that people with COPD had a higher incidence of pocket depth, attachment loss, plaque index, bleeding on probing and bone loss.

The purpose behind this work was to investigate whether I could from a practical approach to create desire for mathematics among students in primary schools. I wanted also to find out how students feel about their current mathematics teaching. By introducing an equation game, and interviewing students to find out their perception of their mathematics teaching, I was able to answer my questions. What I came to was that through a practical and laboratory work, I could create an enjoyable educational opportunity in mathematics. Then during the interviews I also learned that students had not a pre-determined negative attitude towards mathematics.

Bakgrund: En av sjuksköterskans uppgifter är att visa de efterlevande hänsyn och omtanke när någon avlider. Vårdutbildningar är till stor del somatiskt inriktade och ute i den kliniska verksamheten ges mycket knapphändig information kring hur dödsbesked ska levereras. Ett bristfälligt bemötande från sjuksköterskans sida kan leda till att närståendes sorgearbete kompliceras. Syfte: Syftet var att undersöka närståendes situation i samband med ett plötsligt dödsfall samt beskriva relevanta omvårdnadsåtgärder i detta skede. Metod: En litteraturstudie som bygger på fem kvalitativa och fem kvantitativa vetenskapliga artiklar.

Sweden became a member of the European Union in 1995. Consequently Sweden became obligated to implement the Working Time Directive 2003/88/EC (formerly termed 93/104/EC). At that time Sweden considered that their legislation already gave their employees as high level of protection as the directive prescribed. Instead they decided upon an adjustment of the collective agreements concerning working time. A particular EC-restriction was incorporated in the Working Hours Act (SFS 1982:673).

Syftet med min uppsats har varit att undersöka mönster som binder samman normen, barnet och döden i Tim Burtons verssamling The melancholy death of Oyster boy and other stories. Detta gör jag med hjälp av en tematisk och komparativ metod för att undersöka motivet konflikten mellan barnet och samhället i boken i jämförelse med traditionell och subversiv barnlitteratur. Jag inleder med en översikt av hur konflikten mellan barnet och samhället sett ut i barnlitteratur, där drar jag även paralleller till Burtons bok. Därefter gör jag en analys av relationen mellan föräldrarna och barnen i boken i jämförelse med subversiv och traditionell barnlitteratur, för att visa på hur detta motiv kommer fram i Burtons bok. Jag går sedan över till att diskutera relationen till andra karaktärer, samt barnet och normen, för att sedan avsluta med en översikt av motivet döden i barnlitteratur och hur detta motiv framkommer i Burtons berättelser..

Introduction: Palliative care is based on an active total care where the patient's independence and participation are included. Few studies have been based on a concept of freedom in relation to this target group.Aim: The aim of this study was to describe the perception the nurse has about "freedom" - its significance and meaning from an existential perspective for patients with palliative care needs.Method: A qualitative content analysis based on a narrated and written down text from focus groups with adequate examples. The starting point in the focus groups was to focus on existential issues in relation to patients near death. Based on the concept of freedom, has the printouts been analyzed, categorized and codedFindings: Nature, identity, integrity and self-esteem are important aspects for our approach to freedom but freedom is also about existential questions where hope, reconciliation, freedom and forgiveness are included.Discussion: Discussion: We all have our own definitions and meanings of freedom. The largest and perhaps most important fullest freedom is our inner freedom - our own existential freedom.

The object of this two years master's thesis has been to study a specific genre of personal archives by examiningthe archives of nine parents who have lost one or several infants. Using internet-based methods, (e-mail, Skypeand digital photographs), I have conducted qualitative research using a general interview guide technique. Usingresearch from archival theory as well as other fields, my material has been arranged and analysed according tothemes and recurring thoughts picked up from my informants during the interviews.My main theoretical aid has been that the role of parent who has lost a child is the starting point for the creationof the personal archives. Another important theory is my definition of the term ?document? as not dependent onmedium and format, but on usage: if an object has been used as a part of an archive, it is a document.

Catecholamines are stress hormones that are produced and released by a rare tumor called pheochromocytoma. This tumor can cause hypertension which if undiagnosed and untreated leads to death. Since good therapy is available, it is important to find the tumor in time. The most common way to diagnose the tumor is measurement of the biochemical markers; catecholamines and their metabolites, methylated catecholamines.After observation that almost all normetanephrine results for women were higher than the upper reference limit and therefore pathological, the accuracy of the present reference intervals was questioned. Therefore new reference intervals for both urinary catecholamines and methylated catecholamines were developed by analysis of 46 samples using HPLC.

AbstractThe author Selma Lagerlöf was born in 1858 at Mårbacka, in Värmland and died in 1940. Fifty years after Selma´s death were her correspondence released and ten thousand of letters were found in the collection. But it was just the correspondence between Selma and Sofie Elkan who interested people because they wanted to know if Selma and Sofie have had a sexual relationship. Later, in time for Christmas 2008 the Swedish Television shows a film about Selma. "Selma Lagerlöf Society" was critical to the movie and thougt that the movie focused too much on Selma`s sexual orientation.

The aim of this undergraduate thesis was to explore how the welfare officers at palliative units in Stockholm respond to the patients? thoughts and experiences during the last phase of life, as well as exploring their picture of the patients experiences. The research questions of the study were:? How do the welfare officers relate to the patients? experience of their death? ? In what way do the welfare officers respond to the dying patient and his or her experiences?? What knowledge/experience do the welfare officers have and what knowledge/experience do they consider is needed in their profession?To answer the research questions a qualitative method was used where five welfare officers in three different palliative units were interviewed. The empirical material was analysed through meaning concentration and are presented using exact quotations.