Purpose The purpose of this study is to evaluate the treatment results and adverse drug effects for 14 dogs receiving a new paclitaxel preparat named Paccal vet. The evaluated dogs are chosen to enter a pharmacogenomical study. Therefore, this paper intends to give an introduction to pharmacogenomics. Finally this study also aims at finding the homologue genesequenses in dogs to seven genes that are important for metabolism of paclitaxel in humans. Materials and metods The dogs went through 2-4 cycles of paclitaxel treatment, they received a new water-soluble formula named Paccal vet, at dosages of 100-150mg/m2. Treatment results and adverse effects are listed for each dog in table 1.

The student project Elba at KTH started in 2011 and is a project where a battery driven prototype car is developed. The vehicle competes in Eco Shell Marathon in Rotterdam, Holland. In this competition the vehicle that travels a certain distance including several starts and stops with the lowest energy consumption wins. To minimize the consumption is therefore very important, which requires knowledge of the vehicles energy losses.A vehicle's energy losses depends on several factors and can be divided into the powertrain efficiency and the driving resistance. The driving resistance can then be divided in to rolling and air resistance, if smaller losses like vibrations are ignored.

PurposeThe aim of the study was to examine the affects perceived by young people aged 18-19 years old after resistance training outdoors versus resistance training indoor. The aim of the study was also to examine if the rate of perceived exertion was affected by whether the resistance training took place outdoors or indoors. What immediate affects are perceived in conjunction with resistance training outdoors and indoors in people aged 18-19 years?What immediate affects are perceived after resistance training outdoors compared to equivalent resistance training indoor in people aged 18-19 years?What perceived exertion level can be seen in conjunction with resistance training outdoors compared to equivalent resistance training indoors in people aged 18-19 years?How does exercise habit correlate with affects and exertion in conjunction with resistance training? Method22 pupils in a secondary school conducted two resistance training sessions, one outdoors and one indoor. A questionnaire about their mood and exercise habits was answered before and immediately after the training session. Rate of perceived exertion rate was also included in the questionnaire the participants received after the workout.

Staphylococcus aureus is the most clinically important Staphylococcus species and is associated with high mortality in patients with positive blood cultures. S. aureus bacteria may cause a variety of disease manifestations ranging from minor skin infections to life-threatening conditions such as pneumonia, meningitis, osteomyelitis, endocarditis, toxic shock syndrome (TSS) and sepsis. This microorganism belonging to the gram positive cocci may also be part of the normal flora. In Sweden, penicillinase-stable penicillins are the primary alternatives to treat S.

Among researchers it has been established since decades that humans and animals have an internal biological clock that controls certain physiological mechanisms. One example regarding humans is the impairment of lung function during the night, causing the phenomenon ?nocturnal asthma? among asthmatics. Only a few studies concerning respiratory circadian rhythm in horses have been done previously and they showed a daily variation in horses with a chronic or an acute respiratory disease. The technique used in those studies was the conventional technique, which is invasive and less sensitive than the technique used in this study.

Energi är en resurs som måste användas effektiv för att undvika onödig negativ miljöpåverkan och utgifter. Återmatning från nedåtgående malmtåg till uppåtgående malmtåg leder till en effektivisering i energiutnyttjande. Beräkningen av den återmatade energin utgår ifrån tågets lägesenergi och förlusterna från räls, lutning, vind och kurvor. Totalt kan återmatning av energi ge en besparing på 20 % för enkelspår och 20 % respektive 21 % för dubbelspår. Dubbelspår kan ha mer trafik än enkelspår men förhållandet mellan konsumerad och återmatad energi är i princip den samma.

Staphylococcus aureus is the most clinically important Staphylococcus species and is associated with high mortality in patients with positive blood cultures. S. aureus bacteria may cause a variety of disease manifestations ranging from minor skin infections to life-threatening conditions such as pneumonia, meningitis, osteomyelitis, endocarditis, toxic shock syndrome (TSS) and sepsis. This microorganism belonging to the gram positive cocci may also be part of the normal flora. In Sweden, penicillinase-stable penicillins are the primary alternatives to treat S.

Staphylococcus aureus is the most clinically important Staphylococcus species and is associated with high mortality in patients with positive blood cultures. S. aureus bacteria may cause a variety of disease manifestations ranging from minor skin infections to life-threatening conditions such as pneumonia, meningitis, osteomyelitis, endocarditis, toxic shock syndrome (TSS) and sepsis. This microorganism belonging to the gram positive cocci may also be part of the normal flora. In Sweden, penicillinase-stable penicillins are the primary alternatives to treat S.

Haemonchus contortus is the most important bloodsucking gastrointestinal nematode in small ruminants worldwide. It is often controlled by anthelmintics. Even though other methods to control are available, the most efficient way to treat an animal with clinically manifested haemonchosis is to use one of the available broad spectrum anthelmintics: benzimidazoles (BZ), macrocyclic lactones (ML) or imidothiazoles-tetrahydropyromidines or the narrow spectrum drugs salisylanilides or nitrophenols. Anthelmintic resistance (AR) against all groups of anthelmintics in nematode parasites has been reported from many countries, and even multiple AR has been observed. In this study I have investigated the resistance levels to all major classes of broad spectrum anthelmintics in a naturally infected flock of sheep of Red Maasai sheep (RM), Dorper sheep (D) and their offsprings on a research farm in Kenya.

Multiple Congenital Ocular Anomalities (MCOA) is a genetic disease that affects primarily Silver coloured horses of breeds such as the Rocky and Kentucky mountain horses. In these breeds the Silver dapple colour is very popular leading to an increase of affected horses. The major feature of the disease is ocular cysts of variable size. Large cysts also lead to a variety of secondary syndromes, for example retinal detachment. In previous studies the locus for MCOA has been mapped to an interval of 420 kb on equine chromosome six.

Electronic article surveillance (EAS) is widely used in shops and libraries together with an RF-tag attached to the goods or books in order to prevent shoplifting. By implementing the addition of a moisture sensor to the RF-tag, other functions become possible, including the ability to use as an alarm with regards to frozen goods, which have been shipped but which have melted and have, subsequently, refrozen. In- relation to care for the elderly, one time-consuming step involves checking whether there is the necessity for a change of diaper and this can, instead, be based on an RF-tag with an EAS-system alarm. A preliminary investigation was made using the moisture sensors, which involved how the resistance changes when liquid and/or heat is applied. A simulation of the LCCR circuit (RF-tag with the sensor) was conducted in order to determine how the resonance frequency changes for different resistances levels.

Background: Chemotherapy and radiation resistance are major causes of failure in cancer treatment. The response to treatment in cancer cells depends on several mechanisms and pathways such as Janus kinases-signal transducers and activators of transcription JAK/STAT pathway. STAT1 was the first described transcription factor in the STAT family. STAT1 is activated by stimulation of signaling proteins such as type II interferon (IFN- ?) and the activated STAT1 translocates from cytoplasm to nucleus.

Staphylococcus aureus is the most clinically important Staphylococcus species and is associated with high mortality in patients with positive blood cultures. S. aureus bacteria may cause a variety of disease manifestations ranging from minor skin infections to life-threatening conditions such as pneumonia, meningitis, osteomyelitis, endocarditis, toxic shock syndrome (TSS) and sepsis. This microorganism belonging to the gram positive cocci may also be part of the normal flora. In Sweden, penicillinase-stable penicillins are the primary alternatives to treat S.

 Inner resistanceThe aim of this study was to investigate the existence of an internal resistance to a work-related change in people who are long-term sick, and if this is related to an identification as ?long-term sick?. A second purpose to the study was to research in which way this internal resistance to a work-related change manifests and point to possible solutions. A qualitative study was conducted with interviews of experts and people on sick leave to illuminate the subject. The main result was divided into interviewed groups.

The purpose of this essay is to investigate why the two Swedish municipalities of Frykerud and Östmark were the only municipalities in Värmland that were forcibly merged by the state during the ?Municipality block reform? of 1971, and whether local identities played a role in the resistance against this reform.     The study is designed as a comparative case study and builds on both history and political science to analyze the topic from a broader perspective. Based on the research situation three theoretical theses have been formulated, the durability of which will be tested in the analysis part of the essay.    The study notes that Frykeruds resistance against the ?Municipality block reform? started when the reform prevented a planned retirement home construction in the municipality. In the analytical part of the essay, the author discusses how the discontent can be interpreted as symptomatic of bourgeois centralization resistance, as well as being due to the fact that traditional, local self-government as a political subject was perceived as threatened.