Maligna tumörer är något som drabbar såväl djur som människor över hela världen. Därför har stora ansträngningar lagts på att kartlägga mekanismerna bakom en av nyckelparametrarna för tumörtillväxt, tumörangiogenes. Studier har visat att tumörcellerna själva kan inducera neovaskulatur genom ökat uttryck av pro-angiogena faktorer, så som endotelial tillväxtfaktor och angiopoeitin-2. Anti-angiogenesterapi, i form av olika antikroppsderivat, riktar sig fram för allt mot de signalvägar som involverar pro-angiogena faktorer i ett försök att stävja tumörens tillväxtresurser. Idag används främst monoklonala antikroppar, var för sig, tillsammans eller i kombination med kemo- och/eller strålningsterapi. Tyvärr är anti-angiogenesresistens är ett växande problem, troligen relaterat till både adaptiva och inbyggda resistensmekanismer hos de tumörceller som behandlas.

Drug related messages in antidrug campaigns and music related media -A qualitative study about young people?s perceptions Youth are exposed to both promotional and critical drug and alcohol messages in their daily media consumption. The purpose of this study is to examine how youth perceive anti-drug campaigns and drug-promoting messages in music-related media. The empirical material consists of qualitative data, including a focus group and two individual interviews, consisting of youth between the ages of 18 and19. One main finding is that young people perceive anti-drug messages differently, yet they are virtually unanimous about what makes such messages effective.

LGBT people, in Uganda, have since the colonial time been in a vulnerable situation. When the President signed the ?Anti-Homosexuality Act? into law 2014 all forms of same-sex relationships became criminalized. The time after the law passed have been characterized by an increased homophobia and further violence against LGBT people. These are seen as deviants since they do not live according to the social norms, that the right thing to be is heterosexual.

Hematology-instruments that analyze blood cells can at specific cases be followed by manual counting with a hemocytometer. The plastic hemocytometer which has a fixed coverslip and is assigned for disposable use, appears to reduce the problems arising from the use of the traditional glass hemocytometer, for instance coverslip-application difficulty and dust particles. Capillary whole blood sampling may be useful for patients at the emergency department and in addition, a smaller volume of blood is taken compared to venous blood sampling. This study will focus on the platelet- and leukocyte count (PLT and WBC) in venous and capillary blood, in order to compare the plastic- and glass hemocytometers with Sysmex XN-2000 (Sysmex Corporation, Kobe, Japan), and verify if capillary whole blood sampling can be used for the measurement of these hematological parameters. 30 subjects donated both capillary- and venous blood samples and these blood samples were analyzed with glass- and plastic hemocytometers with Sysmex XN-2000 as the reference method.

Syftet med denna uppsats är att undersöka om de grundläggande förmågorna är relevanta även i en anti-terrorist operation, då förmågorna hittills varit ett begrepp inom mellanstatliga konflikter. För att besvara detta används två frågeställningar:? Är de grundläggande förmågorna relevanta för denna typ av operationer?? Vilken eller vilka av de grundläggande förmågorna låg till grund för framgång/misslyckande i operationen?Studien genomförs som en jämförande fallstudie där fyra operationer av militär och polisiär karaktär analyseras utifrån de grundläggande förmågorna. Data erhålls genom textanalys av historiska skildringar som avhandlar respektive operation.Resultatet av studien visar att de grundläggande förmågorna är relevanta för anti-terrorist operationer och tillämpningen av dem kan bestämma utfallet av operationen. De förmågor som låg till grund för en lyckad eller misslyckad operation är verkan, skydd, und/info och ledning..

The subject of the essay is about a society called Klippan and the existing conflicts there between an active racist group and some youths with foreign heritage. The essay also concerns issues like racism, its effects and how it is expressed at different levels in a society. Futhermore we discuss how a community can prevent 'subtle' racism and open declared racism and how to work in a racist manner. We also talk about which role the immigrant youths play in the conflicts and how their behaviour can be understood. Another perspective that is discussed is which aspects can affect individuals to join an active racist group and which factors can make them leave such a group.

Det har skett en utveckling av flera nya biologiska läkemedel sedan slutet av 1990-talet för patienter med en reumatisk sjukdom. Några av dessa läkemedel administreras som intravenösa infusioner, vilket innebär att patienterna är tvungna att komma till en poliklinik för att erhålla sitt läkemedel. Detta kan påverka det dagliga livet samt patienternas oberoende och att undersöka hur patienterna uppfattar denna situation är av betydelse. Inom reumatologin är det ingen studie gjord som undersökt detta. Syftet med studien var att beskriva hur patienter med reumatiska sjukdomar uppfattar beroendet vid intravenös anti TNF-alfa behandling administrerad av en sjuksköterska.Studien genomfördes med en deskriptiv kvalitativ design och fenomenografisk ansats.

Apart from recognizing and neutralizing threats, antibodies also have the ability to regulate immune responses against their specific antigen. IgG administered together with erythrocytes is well known to induce >99% suppression. This has been used to prevent haemolytic disease in new-borns since the 1960's, but the mechanism behind it is still not completely understood. The effect on the primary response is well established, but its influence on induction of immunological memory is still heavily debated. In this study adoptive cell transfer of splenocytes to irradiated mice was used to survey the effect IgG has on induction of immunological memory without disturbance from the primary IgG response.

Schmallenberg virus (SBV) is a novel arthropod-borne orthobunyavirus emerging in Europe in 2011 to 2012. Acute SBV infection causes diarrhoea, fever and reduced milk production in dairy cattle, but it is mainly the reproductive disorders (abortions, malformed foetuses and stillborn animals) in ruminants that have caused substantial economical losses. The prevalence of the virus outside of Europe is poorly investigated. SBV or SBV-like antibodies were detected in Mozambique in 2013, which raised interest for a similar study in Tanzania. In this study in Tanzania, blood samples were collected from 478 sheep and goats from 39 herds in 15 different villages in three districts, covering areas in the north, south and east of Tanzania. The epidemiology of the virus was investigated by tracing antibodies by ELISA and mapping of the virus by PCR was started.

Incompatibility between donors and recipients can cause fatal hemolytic transfusion reactions (HTR), kidney damage and death and immunization of the recipient. Antigens on the surface of erythrocytes in the ABO blood group system and regular natural antibodies against these in the patient?s plasma must be considered. An individual always has a corresponding antibody of IgM in their plasma. Irregular antibodies acquired by transfusion or pregnancy and active in body temperature also cause the HTR incompatibility.

To date, the genus Helicobacter consist of 26 different species and even more species are yet to be characterized. Helicobacter has been detected in connection with diseases in the liver and pancreas in humans and animals. Helicobacter spp. are gram negative, curved, S-shaped or spiral shaped bacteria. They are microaerophilic and have flagella that make them motile. Helicobacter, present in the gastric mucosa neutralize the gastric acid through production of urease that hydrolyses urea to ammonia and bicarbonate.

Uppsatsen behandlar olika definitioner av korruption utifrån internationella regelverk. The United Nations Convention against Corruption (UNCAC) ger en mer specifik definition till korruption än the African Convention on Combating and Preventing Corruption and Related Offences (AUCPCC). Då det finns flera olika definitioner av korruption kan diskuteras huruvida en enhetlig definition är nödvändig. Korruption påverkar även rätten till att bli prövad av en självständig och oberoende domstol. De internationella regelverk som behandlar denna rättighet är the Universal Declaration on Human Rights (UDHR), the African Charter on Human and Peoples? Rights (ACHPR) och the International Covenant on Civil and Political Rights (ICCPR).

Prey species make behavioral decisions to reduce the perceived risk of predation and the time spent vulnerable to predation. Behavioral responses to predators are for example selection of specific habitat types and the presence of predators influence individual vigilance. Furthermore, there is a variation in feeding niches with different herbivores focusing their foraging effort on different vegetation types which is also expected to affect the choice of habitat. Behavioral data on anti-predation and foraging behavior at on waterhole is collected from Thomson?s and Grant?s gazelles at Ol Pejeta Conservancy (0°00?N, 36°56?E) located in semiarid bushed grassland in Laikipia district of central Kenya.

Background: As a part of a national health control program, Statens VeterinärmedicinskaAnstalt performs diagnostics to screen flocks for certain pathogens causing high mortality,morbidity and/or serious economical losses. There are several viruses in the programincluding IBDV (infectious bursal disease virus), IBV (infectious bronchitis virus) and NDV(Newcastle disease virus). Method: 96 serum samples were collected from different poultryflocks in Sweden and analyzed by ELISA, which are currently used in the health controlprogram as well as by a commercial prototype of a multiplex immunoassay manufactured byLuminex Corp., which is currently under evaluation at the United States Department ofAgriculture USDA. This 4-plex assay detects antibodies for the three above-mentionedviruses as well as antibodies of avian reovirus. In the context of this study the ELISAs run inroutine diagnostics as well as a REO ELISA were used as the standard for comparison.Result: The antibody concentration in serum from vaccinated chickens was high while theantibody concentration level in serum from not vaccinated chickens was low.

Background: As a part of a national health control program, Statens VeterinärmedicinskaAnstalt performs diagnostics to screen flocks for certain pathogens causing high mortality,morbidity and/or serious economical losses. There are several viruses in the programincluding IBDV (infectious bursal disease virus), IBV (infectious bronchitis virus) and NDV(Newcastle disease virus). Method: 96 serum samples were collected from different poultryflocks in Sweden and analyzed by ELISA, which are currently used in the health controlprogram as well as by a commercial prototype of a multiplex immunoassay manufactured byLuminex Corp., which is currently under evaluation at the United States Department ofAgriculture USDA. This 4-plex assay detects antibodies for the three above-mentionedviruses as well as antibodies of avian reovirus. In the context of this study the ELISAs run inroutine diagnostics as well as a REO ELISA were used as the standard for comparison.Result: The antibody concentration in serum from vaccinated chickens was high while theantibody concentration level in serum from not vaccinated chickens was low.