The process of drug discovery is very slow and expensive. There is a need for reliable in silico methods; however the performance of these methods differs.This work presents a targeted study on how the drug discovery methods used in OpenEye?s tools ROCS, EON and FRED perform on targets with small ligands. It was examined if 12 compounds (markers) somewhat similar to AMP could be detected by ROCS in a random data set comprised of 1000 compounds. It was also examined if EON could find any electrostatic similarities between the queries and the markers.

This paper researches how the palimpsest concept is used in relation to landscape, and how it can function as a tool within landscape architecture. Palimpsest originally refers to old parchment handwritings, where new text has been applied on top of effaced, but still discernable, earlier writing. Superimposition of information is the core of the palimpsest concept, used within a range of scientific as well as cultural fields. The purpose of this paper is to find how a landscape palimpsest can be distinguished among the many different layers of landscape, such as historical or cultural, and to examine the potential use of the concept in theory and practice of the landscape architecture field. The study is conducted as a literature survey, examining the use of the palimpsest concept within academic works related to landscape.

According to the curriculum for primary schools, pre-school and after-school Lgr11 says that students should experience different feelings and moods using different forms of expression including drama (Lgr11 2011:10). The purpose of this study was to examine how educational drama is used in three elementary schools and for what purpose in teaching. The aim was also to examine the four teachers' perceptions of what educational drama means to them.I have used a qualitative approach with interviews and contacted four teachers from three different schools to get different information for my study. Three of them were educated teachers and one of them was an actor. The information provided in the interviews was analyzed using educational drama theory and previous research. The interviews with the teachers and the actor showed the use of different methods of educational drama in education.

The purpose of this study has been to compare the present with the future syllabus of mathematics. With a text analytical approach has questions about how the structure is different, how the look at knowledge has changed and which learning theory that characterizes the two syllabus been answered. As a theoretical framework I adopt three different learning theories, behaviourism, cognitivism and the socio-cultural perspective. The pervious research I have looked at is the concept of knowledge an the underlying theories to previous curriculum. During the increase results in the greatest difference seen in the structure.

Package design constitutes an important marketing and differentiation tool in an increasingly competitive food market, particularly in the category of daily consumer goods where the turnover rate is high and the purchases are based on self-service (Hine, 1997; Spethmann, 1994; Underwood, 1999). Media fragmentation undermines the traditional marketing tools and the demands for packaging are bigger than ever. A package must not only sell a product, but also tell, through design, how the product is used and express the values that the trademark owner wishes to convey to the end customer (Underwood, 1998). The understanding of the role of packaging as a marketing tool has increased, but the initiators inside the packaging industry in Sweden still think that the Swedish packaging industry is developing slowly. They often describe Swedish packages as homogeneous and unimaginative.

This study investigates the use of the social network Facebook among 67 Swedish libraries; 27 academic libraries and 40 public libraries. Data is collected through an analysis of the libraries? Facebook pages and through an email survey. To analyze the data, a series of statistical analyses were performed.The results indicate that the public libraries more actively posted Facebook updates than the academic libraries and that the libraries that had a policy for use of Facebook/social media more actively posted updates than those libraries that did not have such policy. The libraries use Facebook mainly to post links and photos and to announce events, provide book recommendations, and to emphasize special occasions.

This study in Environmental Science examines the amendment of the EU-Directive on. Greenhouse gas emission allowance trading. The Directive is to be considered as a tool for fulfilling the obligations that the Union and its member countries have taken on through the 1997 Kyoto agreement together with the protocols proposed at that time. The flexible mechanisms of the protocol are intended as instruments for limiting the climatic changes arising from anthropogenic sources, emission allowance trading being one of these mechanisms. The results presented here consist primarily of an analysis of interviews with various experts in the field of emission control concerning the possibilities and problems attending the process of implementation.

There is a discrepancy between national school guidelines towards inclusive education, and the current political trend towards economic efficacy, that may be problematic for teachers. The aim of this contextual study is to formulate a contextual understanding of the participating teachers? perceptions of their effort to help all their students achieve the goals set forth by school curricula, and use this understanding for the purpose of suggesting points of entry for special needs educators´ guidance of teachers? practices towards more inclusive education.Information was gathered by sending an extensive web questionnaire to all teachers within a given headmaster´s administration, sending web questionnaires to a majority of third grade students taught by those teachers, conducting interviews with a few of the participating teachers as well as with the special needs educators, carrying out a classroom observation, and gathering additional information concerning working conditions and social interactions.The data gathered in this case study has been subjected to an analytical process comprising of an assessment of the degree of inclusive approach, using the Inclusive Approach through Participation as well as the Framework of Participation, technical triangulation of all data post the inclusive assessment, and analysis of context by the Ecology of Human Development/the Bioecological Theory.The analytical process has resulted in a contextual description that has enabled me to suggest possible points of entry to be used in special needs educators? guidance of teachers? practices towards inclusive education. The degree to which there exists a collegial sense of security, varied forms of teacher-student interactions, collegial cooperation, pedagogical discussions, a dialogue in search of mutual understanding, and consequent follow-ups appears, in the light of the limited selection of participants, as relevant to these teachers ability to help their students.Further research is needed to identify valid points of entry for special needs educators? guidance of teachers? practices towards inclusive education.

Physical inactivity is the fourth leading risk factor for global mortality. To prevent and change this the society need to develop good approaches and interventions to promote physical activity. The purpose of this thesis was to investigate which experience existing users have of smartphone training applications. Also to study if this can be a possible resource for health promotion. Six active users applied to participation after they had seen an ad in social media.

Abstract In order to work with historical sites, there must be an understanding of the complexity around the preservation of parks, gardens and landscapes and the approach to be used in the rebuilding and renewal. These issues are an important starting point of this essay. Historical environments give us as individuals an insight in who we are and from where we come, which is an important part of our need of identity as human beings. Without them, our roots in the past will be non-existent. The importance of this support base lies not only in the garden conservation, but also in the picture of developments, which we have through of as time mirrors of our living environment.

Value stream mapping is a tool that is frequently used by many different companies. It is a great tool used to achieve the work that follows the theories of lean production. The tool is used, however, only frequent on the factory floor and the method is also designed based on this type of use.An interest of applying the method on administrative parts of the company has occurred lately. Administrative parts of the company refers to the part that does all the planning such as purchasing, receiving orders, customer contact, contact with factory floor and other work that is made around the actual manufacturing. But the knowledge about applying value stream mapping on the planning part of the company is lacking because the method is relatively new.In this work, a comparison is made between the introduction of value stream analysis on production and planning.

Due to a constantly increasing competitive pressure it is of great importance to constantly strive for improvements in order to gain competitive advantages. Lean Production is a concept that has been introduced with the aim to minimize waste and increase profitability. The purpose of this report is therefore to investigate how to perform effective planning according to the principles of Lean Production, in companys with customer exclusive products, through a case study at Sandvik Mining and Construction (SMC), and to investigate how SMC kan improve their planning of drifting rods at the production unit in Sandviken.The study started by creating a theoretical framework, to describe the subject planning and planning based on Lean Production. This frame work constituted the base for the case study which took place at Sandvik Mining and Construction, and also for the model and planning tool that has been introduced.The result of the study is partly a general model with factors that contribute to a more effective planning. These factors has beed identifed as SMED, which focuses on reducing set up times and in the end to facilitate the planning.

This thesis describes redesign and adaption of a products housing. In order to make it more economical to produce at a lower production volume. The thesis is based upon a prototype that a previous student developed for injection moulding. The goal is to find alternative manufacturing methods, but also to identify parameters that affect the cost of the injection moulding tool.The housing must be tough in order to protect the circuit board inside. But at the same time it must allow sound, light an electrical communication to pass through.

This paper examines and analyzes effects of the introduction of a new management control system tool within a Swedish public health organization, the Södra Älvsborg hospital, and its possible effect on organizational change. The new management control system tool, known as the SÄS-model, has been widely criticized for being too costly and with too small positive effects to be shown. Our approach has with that as a background been to examine whether the implementation of the SÄS-model and its balanced scorecard has been able to result in effects regarding organizational change. We have through a case study aimed to analyze how a management control system, much alike one that is typically used within foremost private organizations, can promote organizational change. Our results suggest that the implementation of the SÄS-model and the balanced scorecard has given the organization clearer visions and goals.

The goal of this project was to together with Cochlear Bone Anchored Solutions AB develop a new cleaning tool for their Baha?systems. Cochlear BAS AB is a daughter company to Cochlear Limited based in Sydney, Australia. Cochlear BAS AB is situated in Gothenburg and with its 150 employees develop and manufacture the Baha?system.