The process of drug discovery is very slow and expensive. There is a need for reliable in silico methods; however the performance of these methods differs.This work presents a targeted study on how the drug discovery methods used in OpenEye?s tools ROCS, EON and FRED perform on targets with small ligands. It was examined if 12 compounds (markers) somewhat similar to AMP could be detected by ROCS in a random data set comprised of 1000 compounds. It was also examined if EON could find any electrostatic similarities between the queries and the markers.

This degree project contains a theoretical and a practical part about magazine design. Literature aboutthe subject?s typography and magazine design has been studied and put into practice on the professionaljournal Ingenjören. Besides of that a study about the history of magazine typography for the lastfifty years has been done.Typography and other design factors are important for the magazine to be readable and gives at thesame time the magazine an identity of its own, which has become more and more important throughoutthe last decades.The result of this degree project is a new design for Ingenjören, a design that agrees more with howthe journal want to be considered. A new template, a dummy and a manual have been produced.

Detta är ett examensarbete inom textdesign, som har undersökt hur användarinformationen för två specifika datorprogram bör utformas. Slutsatserna har dragits utifrån vilka problem användarna stöter på i programmen, riktlinjer för informationsdesign och teknikinformation, samt användartester.En slutsats blev att behovet av teknikinformation för det ena programmet, EDI-systemet Edionet, redan var tillfredsställt. En lämplig lösning för det andra programmet, publiceringssystemet Readyonet, var att skapa en kort lathund vid sidan av den utförliga handledning som finns integrerad i programmet. Ett utkast av lathunden utformades utifrån insamlad empiri, och testades och reviderades..

This study is about young girls' mental health. In Sweden, the mental health deteriorated in recent years among adolescents, particularly among young girls. Results of the Liv & Hälsa Ung in 2011 in the southern part of the county of Örebro is the basis for the study. The results of the survey showed that a remarkable number of young girls rate their mental health as poor. The purpose of this study was to examine what young girls in southern part of the county of Örebro County believes are contributing factors for good mental health and the method used is qualitative.

We acknowledge the lack of empirical studies of the performance of analyst target prices in the Swedish stock market by examining the profitability of target prices for stocks publicly traded on the Stockholm Stock Exchange. We use consensus target prices issued between 2006-2010 and create two different strategies to observe the abnormal returns generated during this period. Going long in the top decile stocks with the best target prices and going short in the bottom decile stocks with the worst target prices generates a statistically significant abnormal buy-and-hold return of 8.9%. An active strategy with daily portfolio rebalancing and a timely response to target price changes generates a less significant monthly alpha of 1.4% against CAPM. The results show to be robust against the size effect discovered by Fama and French.

The author is active as a musician in the field of historically informed performance practice (HIP) which emanated from the 20th century early music movement. Studying of historical sources has a central role, but the problem of how interpretation and selection of source material is affected by art and music ideals of our time, is commonly acknowledged. Georg Joseph Vogler shows in a series of articles in "Betrachtungen der Mannheimer Tonschule" (1778-1781) how Stabat Mater by Pergolesi could, and in his opininon, should be improved. The purpose of this thesis is to investigate how this source can be used from the standpoint of a performing musician: How can I use Vogler?s methods in my playing?The introduction problematizes Vogler?s action in relation to his time, and to ours.

Nowadays Wireless LAN is playing a more and more important role in network systems. After 1999, in which the IEEE organization published its Wireless Local Network standard 802.11[1], many people saw the advantages of the standard but also the lack of support for multimedia streaming. A lot of research work has been done on the proposed IEEE 802.11e standard draft during the past 4 years. It is supposed to be able to fully support Quality of Service. The final version will be published early in 2004.

Half of Sweden?s 140 000-150 000 sows are culled and replaced by 75 000 gilts annually. Culling of old sows is necessary and allows new breeding material to enter the herd. However, many of the culled sows are young, and have not yet become profitable at the time for culling. Therefore, it is an important question for the pig industry, how to raise gilts to sows with a high and sustainable production level.

The focus of the thesis is an information search technique called manual query expansion, which aims to improve the retrieval per-formance in a search system by adding terms to the search query. The study looks at the query expansions done by LIS students, and the eventual beneficial effects by using a search help during the search process. The empirical data have been collected thro-ugh an experiment, with an experiment group as well as a control group. The conclusion is that the students need more education in query expansion in order to be able to use it correctly. There are significant differences between the groups in several aspects, for example in the use of search terms, parentheses, and truncation.

The aim of this study is to investigate how multiple tree handling harvesters perform compared to earlier developed standards. The study shows that multiple tree handling harvesters are more efficient in thinnings stands with mean stock volumes less than 0,12 m3fub per stock. The increased efficiency is different for different mean stem classes. In stands with a mean stem volume of 0,04 m3fub per stock, the increase can be as high as 40 percent while it is about 10 percent in stands with a mean stem volume of 0,12 m3fub. Comparisons have been done between stands that are felled with partly limbed stands and stands without partly limbed assortments. The difference in performance is clear and shows that the partly limbed assortments strengthen the multiple tree handling harvesters positive effects in low dimension thinnings.

Bakgrund: Munvård är en viktig del av omvårdanden för patienters välbefinnande. Daglig rengöring av tänder och munhåla är grunden till att förebygga olika sjukdomstillstånd. Undersökningar visar att kunskapen om munvård är låg hos vårdpersonal. Syfte: Syftet med studien är att belysa vårdpersonals uppfattning om munvård. Metod: En litteraturstudie har gjorts där fem artiklar ingår.

The subject of this thesis is the application of Support Vector Machines on two totally different applications, facial expressions recognition and remote sensing.The basic idea of kernel algorithms is to transpose input data in a higher dimensional space, the feature space, in which linear operations on the data can be processed more easily. These operations in the feature space can be expressed in terms of input data thanks to the kernel functions. Support Vector Machines is a classifier using this kernel method by computing, in the feature space and on basis of examples of the different classes, hyperplanes that separate the classes. The hyperplanes in the feature space correspond to non linear surfaces in the input space.Concerning facial expressions, the aim is to train and test a classifier able to recognise, on basis of some pictures of faces, which emotion (among these six ones: anger, disgust, fear, joy, sad, and surprise) that is expressed by the person in the picture. In this application, each picture has to be seen has a point in an N-dimensional space where N is the number of pixels in the image.The second application is the detection of camouflage nets hidden in vegetation using a hyperspectral image taken by an aircraft.

The purpose of this thesis is to examine how key performance indicators are being used as performance management tools within the production industry. Specifically the purpose is to investigate how the KPI:s within the telecommunications industry drives reusability regarding production test systems. This thesis will also highlight today?s cost models and suggest improvements of the KPI and what new ones could be introduced. A case study at Ericsson AB has been performed.

Management control systems are a popular area of research and a lot of new research has been done over the past years. This development has been looking into new situations and circumstances, and interdisciplinary studies are being made to further understand the connection between different fields of study. A new field of study that has grown significantly over the past few years is the connection between management control systems and entrepreneurship. Leading researchers have proposed a number of questions for further research and one of them is the board of directors? use of management control systems in entrepreneurial firms.The purpose of this study was to examine the differences and similarities in the board of directors? use of management control systems between entrepreneurial and non-entrepreneurial firms.The study was conducted as a deductive qualitative study through interviews with respondents from entrepreneurial and non-entrepreneurial firms.

Unhealthiness is not just a damaged back or asbestos. The fact that mental ill-health seems to increase in our society is well known. Statistics from Arbetsmiljöverket proves a fourfold increase of work-related disorders since 1997. These are primarily caused by organizational and social factors, 60% are considered caused by stress and a heavy workload. Sick leave due work related fatigue and depressions are scarily common today.