The problem of finding targeted medicine is a central problem in chemotherapy. From this point of view the ubiquitin-proteasome system is a highly promising object in the pharmaceutical approach. Proteasome plays a critical role in cellular protein degradation, cell cycle and apoptosis regulation.Proteasome inhibitors are substances blocking the actions of proteasome. Cancer cells are more sensitive to inhibition of the ubiquitin-proteasome system than normal cells. Therefore proteasome inhibitors have the potential to be successfully used in the cancer treatment.The study aimed to test various substances to identify possible proteasome inhibitors with the IncuCyteTM FLR image system and fluorometric microculture cytotoxicity assay.

The aim of this Master?s Thesis is to find out whether bibliotherapy, in an unspokenform, is practiced in already existing group formations to be able to determine how practicalbibliotherapy can be seen in a Swedish context and thereby open the possibility for development.To fulfil this purpose I decided to do a case study on a nearby book reading circle for adultchildren of drug addicts. I made three qualitative interviews; two of the mentioned book readingcircle?s leaders and one participant/help leader. I used the following set of questions: What isincluded in the concept Bibliotherapy and how does that relate to practice? How has the bookreading circle examined in this case study proceeded, which methods were used and what kind ofliterature has been used and also what kind of effects did this reading circle have on itsparticipants.

Syftet är att beskriva symtom och biverkningar som kvinnor med avancerad bröstcancer och cytostatikabehandling rapporterat i ett datoriserat rapporteringssystem före läkarbesök. Undersöka tillfredsställelsen med detta system; se om det finns en skillnad mellan äldre och yngre; undersöka kvinnornas uppfattning om vad som kan förbättras i uppföljningen av symtom/biverkningar samt stödet från läkare. Detta är en kvantitativ, deskriptiv tvärsnittsstudie baserat på rapporteringssystemets databas samt enkätundersökning. Biverkningarna trötthet, smärta och nervpåverkan rapporterades mest frekvent. Tidsåtgången för rapportering ansågs utav de flesta vara kort eller mycket kort och formuläret upplevdes av majoriteten vara ganska lätt till mycket lätt att använda oberoende av datorvana. Läkaren ansågs från hög grad till mycket hög grad vara ett stöd i att hantera symtom och biverkningar av två tredjedelar av respondenterna.

Native spider silk is an attractive lightweight natural polymeric material with a unique combination of strength, extendibility and flexibility. Synthetic, recombinant spider silk is an attractive biomaterial with several possible fields of application. When a foreign material is introduced to blood, this can for example cause unwanted coagulation and complement activation. The aim of this study was to investigate if coatings of heparin or albumin could improve the blood compatibility of films of recombinant spider silk and to develop an initial method to do so. Hypothetically, objects like pacemakers, stents and dental implants could be covered with spider silk films of high blood compatibility to reduce potentially harmful foreign body reactions caused by the immune defense. Increased blood compatibility would likely lead to improvements for both the individual patients and the society thanks to reduced load on healthcare institutions. Our objective was to assess the blood compatibility of both functionalized and non-functionalized recombinant spider silk by evaluating coagulation and activation of the complement system of the immune defense. Coagulation was evaluated visually on glass slides and complement activation was analyzed by measuring the concentration of the complement system mediator C3a in blood samples that had been exposed to the different materials. This study introduces a non-toxic and easy performed method of improving the blood compatibility of recombinant spider silk films by adding a heparin coating. Heparin coated surfaces had statistically significantly higher blood compatibility than uncoated surfaces. The effects of albumin coating of films were less clear compared to the results of heparin coated films. Complement activation could not be evaluated because of high activation in all samples prior contact with the materials that were included in the study..

The aim of this study was to examine self-harming women?s own experiences. To try and raise understanding and awareness about how they themselves create their identity and meaning round the self-harming behaviour. Our three questions were; how do the young women conceive society?s reactions on their self-harming behaviour? Do the young women express an imposed or self-elected alienation? If so, in what way? In what way do the young self-harming women construe their own identity in relation to the self-harming behaviour?We have used a narrative approach when we have examined the blogs as life stories in the sense that all our lives and everything in them is a story by definition.

The Swedish Prime Minister, Tage Erlander, made a speech on the 22 of August 1961 in which he dismissed speculation that Sweden was seeking to abandon its neutral stance and non-alignment in foreign policy with a view to requesting membership of the European Economic Community. The reason was that the EEC was supposed to have a political part where a connection with NATO should have existed. This speech led to a domestic discussion which has been called the most intense debate of foreign affairs in recent history. The purpose of this paper is to analyse the reactions of the other parliamentary parties to Erlander?s speech.

Bakgrund: Läkemedelshantering utgör en stor del av det dagliga arbetet för sjuksköterskor. Varje år orsakas ett stort antal patienter skador på grund av brister i läkemedelshanteringen. Ett ständigt säkerhetsarbete där avvikande händelser rapporteras och utreds kan förhindra att fel upprepas. Lex Maria är en form av avvikelserapportering som syftar till att identifiera bakomliggande orsaker till den avvikande händelsen. Syfte: Syftet med denna studie är att identifiera vilka fel som begås i samband med läkemedelshanteringen inom primär-, kommunal- och hemsjukvården och som medför, eller riskerar att medföra, skada för patienten och där sjuksköterskan hade kunnat påverka händelseförloppet.

Huvudsyftet med studien är att undersöka om det finns skillnader i risktagande mellan individer som bor i olika områden inom Gävle kommun, med konsumtion av försäkringsskydd som riskmått. Gävle kommuns 18 områden är indelade i fyra regioner vilka är centrum, norr, söder-väst och öst.Delsyftet är att studera vilka individuella variabler såsom ålder, förvärvsinkomst, boende, boendeförhållande, utbildning samt sysselsättning som påverkar konsumtionen av försäkringsskydd. Vidare syftar studien till att studera hur två fenomen, adverse selection och moral hazard, vilka härrör från informationsasymmetri, påverkar konsumtionen av försäkringsskydd.Metod: Arbetet utgår ifrån fyra stycken valda metoder vilka är klassificering, kvantifiering, hypotesprövning samt komparation. Vidare har sambandsmåttet, chi-två (?2), använts för att antingen falsifiera eller inte falsifiera en uppställd hypotes.

To be educated in global climate issues can be challenging for pupils. This may contribute to anxiety and feelings of helplessness. Global climate change may also be a challenge for educators to convey to young learners, f-3. Educators can experience various problems when it comes to teaching about climate issues. The subject of climate change is a broad and complex area, according to the studied material in our thesis.

In the past year, Ozempic has been observed internationally, as well as in the Swedish press, due to its rapid rise in popularity, its off-label use for weight loss, and the ethical and societal debates surrounding availability and impact. The purpose of this study is to examine how Ozempic is portrayed in the four largest Swedish daily newspapers: Svenska Dagbladet, Dagens Nyheter, Expressen and Aftonbladet. The aim of the thesis is to identify the frames within which the drug is described to acquire knowledge of how it influences public perception of it. Every article published between the first of March until the first of November has been included in the study, if it bottoms in the defined phonomenon. The method used is a qualitative text analysis in consideration of Entman?s framing theory, which is focusing on identifying dominant themes, problem definitions, proposed solutions, and the actors attributed responsibility in the coverage of Ozempic in Swedish press.

Fast pyrolysis is a method for converting biomass into three energy rich products: char, gas and bio-oil, where the latter is most interesting.  Pyrolysis is an endothermic process where biomass is heated in an anaerobic environment and, with the right operating conditions, up to 80 %wt bio-oil can be extracted. Key parameters for fast pyrolysis are: stable reactor temperature (~500°C), short residue time for gas in the reactor (<2 s) and a very high heating rate for the biomass. Today there are several different process solutions for fast pyrolysis, where fluidized beds and rotating cones are most developed. Bio-oil has compared to fossil oil: lower heating value, low pH and also polymerizes with time. Because of this upgrading is desirable for increasing competitiveness.

Syftet med denna kvalitativa studie var att undersöka missbrukande kvinnors tankar kring och upplevelser av samhällets och nätverkets bemötande samt attityder till kvinnligt missbruk. För att besvara uppsatsens frågeställningar genomfördes fem intervjuer med kvinnor som missbrukat främst alkohol. I analysen granskades resultatet utifrån genusperspektiv, stämplingsteori samt teorier om bemötande. Då det inte fanns någon tidigare forskning som direkt berörde studiens syfte användes närliggande forskning. Den tidigare forskningen visade att män och kvinnor i vårt samhälle bemöts på olika sätt.

ABSTRACT. Introduction: Human Immunodeficiency Virus (HIV) is a retrovirus which occurs worldwide and spreads between humans mainly through sex, from mother to child, blood and blood products and between injecting drug users. After been infected with HIV for a couple of years the final stage of the infection progress into Acquired Immune Deficiency Syndrome (AIDS), and there is no cure or vaccine, only medication that delays the development of the disease. Objective: The aim of this thesis is to examine the preventive work against HIV in Sweden, the groups at risk for getting infected and to highlight sexual attitudes and behaviours among adolescents and young adults. Method: A literature based study method was used and the material is based on scientific articles and reports from active actors within the field of HIV prevention.

Hypothermia during anaesthesia is a well-known phenomenon that may cause several side-effects such as greater risk of postoperative wound infection and increased risk of heart complications. The most efficient way to avoid this is to prevent hypothermia from occurring. The aim of this paper was to compile the research on the most efficient way to prevent hypothermia during anaesthesia for cats and dogs, and to compare these results to how Swedish animal hospitals prevent hypothermia today. To investigate this, a survey was sent out to several animal hospitals around Sweden to see what methods they used to prevent hypothermia in their clinics. It is difficult if not impossible to prevent the body temperature from falling slightly when anaesthesia is induced because of the drug interactions in the body that follow from the drugs given. A 1-1,5°C decrease in body temperature is to be expected and is difficult to avoid.

The purpose of this study was to examine the controversy surrounding the Swedish methadone assisted rehabilitation program over time. Which course has the Swedish methadone assisted rehabilitation program, and the controversy surrounding it, taken since the start? Which arguments have been for and which have been against a methadone assisted rehabilitation program in Sweden, and what are these arguments based on? We chose to write this thesis as a literature study to get a broad and in depth picture of the development of the program in Sweden. In our analysis we used social constructionism and a medical aspect on substance abuse as theories.It is clear that it has been, and still are, differences in opinions when it comes to the effects of the program. As early as in the 1980's the methadone assisted rehabilitation program was scientifically proved effective and approved by the Swedish Board of Health and Social Affairs.