The problem of finding targeted medicine is a central problem in chemotherapy. From this point of view the ubiquitin-proteasome system is a highly promising object in the pharmaceutical approach. Proteasome plays a critical role in cellular protein degradation, cell cycle and apoptosis regulation.Proteasome inhibitors are substances blocking the actions of proteasome. Cancer cells are more sensitive to inhibition of the ubiquitin-proteasome system than normal cells. Therefore proteasome inhibitors have the potential to be successfully used in the cancer treatment.The study aimed to test various substances to identify possible proteasome inhibitors with the IncuCyteTM FLR image system and fluorometric microculture cytotoxicity assay.

The essay deals with adult education from a local perspective more specifically that ofthe IOGT lodge Leon Garnbetta in Varberg. The material that has been used covers a limited period of time, which stretches from 1883 to 1926.This temperance lodge was founded in 1883 and is still active. The essay provides a historical survey of the temperance movement in Sweden and depicts the ideas behind adult educa­tion, but it also gives a more general historical account of the town of Varberg and its popu­lar movements.By studying handwritten records from the lodge it is possible to establish a picture of its work, activities, discussions, its striving for democracy, educational activities and the principles behind these and finally the lodge's own library which was started at an early stage. All these aspects are then treated in a historical and a political context..

En av de svåraste utmaningarna som ett företag står inför är jämvikten mellan användbarhet och säkerhet, så att ingen av dessa väger över och på så vis påverkar organisationen negativt. Utifrån intervjuer med anställda har användbarheten undersökts, även samtal med ansvariga inom IT-säkerhet har givit förståelse för företagets arbete inom området. I det undersökta företaget kan man se att stor tyngd läggs på säkerheten, vilket kan påverkar användbarheten för användarna. Eftersom det i nuläget saknas en utredning och ett riktigt beslutsunderlag av vilka användare som skall ha vilka behörigheter på sina datorer, ges i slutet av arbetet rekommendationer till företaget gällande användartypernas fördelning utifrån säkerhetsperspektiv och ur användarnas egen användbarhetsuppfattning..

The EU Water Framework Directive has led that management follows the boundaries of natural catchments.The Swedish waters suffer from a nutrient overload that originates mainly from diffuse sources such as agriculture and the subcatchment of Hackstabäcken in Vallentuna Kommun, just north of Stockholm, has been chosen for this study because of its high nutrient load and because it has undergone obvious changes in land use through the years.In this study, the land use in 1902 is compared with the land use in 2011 in order to investigate if it has influenced the ability of the landscape to produce ecosystem services related to nutrient removal. These services will continue to be produced as long as the system is stable and resilient, but when landuse changes and manure from horses increases it will lead to disturbances that can convert a system from one regime in to a completely different one. That will result in loss, or degradation, of ecosystem services such as denitrification, phosphor sedimentation and adsorption, vegetation uptake and infiltration.The results of this study are based upon area calculations of landuse from old maps from 1902 and 2011. Through these maps it becomes clear that the forests in Hackstabäcken, has increased with 170 ha together with an urbanization of 311 ha, at the same time as wetlands and arable land has diminished and lakes has suffered from reductions. Wetlands have been reduced with 76 ha and the ones remaining are of insufficient quality from a nutrient removal perspective.Data from 1902 and 2011 regarding number of horses and bovines indicated a decrease in bovines and an increase in horses.

Examensarbetet handlade om att integrera Microsoft Outlook 2003 med EBI Systems plattform Platina. För de som inte vet vad Microsoft Outlook är så kommer här Microsofts definition: Microsoft® Office Outlook® 2003 är ett personligt informationshanterings- och kommunikationsprogram där du hanterar e-post, kalendrar, kontakter och annan personlig och grupprelaterad information. Vill du veta mer om Platina så finns det information i Bilaga E. Målet med examensarbetet var att få tillgång till filer och funktioner från Platina i MS Outlook. Användaren av Outlook skulle även kunna spara e-post direkt till Platina databasen på olika sätt, till ärenden, till handlingar och till vanliga mappar.

Biogas is a renewable energy produced through anaerobic digestion, which means that organic matter is degraded by microorganisms under anaerobic conditions. The produced biogas can then be used for cogeneration, electricity, heat or upgraded to vehicle gas. Eskilstuna Energy & Environment AB has four digesters at Ekeby water sewage treatment plant, Eskilstuna. One of the biogas reactor (RK4) is equipped with a jet-mixing system while the remaining digester uses top-mixing. The mixing system is an important parameter to achieve optimum operating conditions for the process regarding gas production and degree of digestion.

The purpose of this bachelor thesis is to examine the views of the elderly and the caregivers that appear in brochures for the elderly and the discourses that can be found within. The data that the study is based on was collected and analysed using content analysis and Faircloughs (1992) critical discourse analysis. The theoretical frameworks that have been used are social constructionism, critical discourse analysis, assortment and protest, and New Public Management. The results showed two images of older people (I) the elderly as active and autonomous and (II) the elderly as passive and in need of help. The results also showed two pictures of the caregiver (III) the caregiver and NPM, and (IV), the non-profit care provider as a complement.

The purpose of this study was to investigate whether resistant maltodextrin is suitable as a fiber source in the probiotic fruit drink ProViva Mango without affecting the probiotic bacterium Lactobacillus plantarum 299v, viscosity or the sensory experience of the drink. Resistant maltodextrin is produced from hydrolyzed corn starch and is classified as a soluble dietary fiber. It is relatively resistant to digestion in the small intestine, where approximately 10% can be broken down, 50% can be fermented in the colon by the intestinal flora and 40 % is excreted in the faeces. Resistant maltodextrin has several important qualities when it comes to food processing. When added in a product, it does not affect the viscosity or taste and it is heat and acid stable.

A new shipyard on the island of Beckholmen consisting of a new ship hall and complementary workshops. The program is extended with rentable industrial space for other smaller companies to take advantage of synergies with the yard and to create an active maritime cluster around Beckholmen. By building a marina and a port at the northern shoreline of the island the shipyard can expand their potential customers to non-commercial and larger recreational boats that are becoming increasingly common in Skärgården. The port is also supplemented with a combined naval fuel station, harbor office and a small café. The boat traffic in the region gets a additional stop at the end of the port and act as an additional gateway to Djurgården. Several small retail spaces with direct access to the water is created along the promenade between the port and Djurgården. The shipyard gets a modern and efficient industry building, while the island is made available to the public again, and Beckholmen will hopefully take an equal place in the city's consciousness as it does visually in the inlet to Stockholm..

This thesis is based on qualitative text analyses of four works of fiction, used as teaching materials in the school subject of Swedish, from a queer theoretic perspective. The purpose of the study is to examine how sexual identities and expressions are being presented, as well as what positions are offered a reader, in relation to the heterosexual norm. Basis for this thesis are the schools fundamental values, which highlights the importance that intolerance be confronted through both knowledge and active measures, and the syllabus, which states that fiction should be viewed as a tool for identity development as well as an understanding of the outside world.The analyses reveals a distinct connection between the generally accepted heterosexual norm and a professed (or taken for granted) heterosexuality which is being carried out by the characters or the books as a whole. Out of the four titles only one disputes this norm, by offering a wide range of sexual identities and expressions. These expressions, however, are being invalidated ? through insufficient ability to relate to the norm ? or made invisible ? through an imagined heterosexuality which, by superiority over other expressions, excludes them..

Citizenship information is defined as the information the citizen needs to be able to take part in and influence the society. Since it is a democratic issue that information concerning the citizens role in society really reaches the citizens, it is of importance to study how the citizens proceed when they have a need for this information. The aim of this Masters thesis is to investigate how our eight informers proceed when they experience this need in a non-work situation. We performed qualitative interviews. The most important part of our interviews was the introduction of some fictitious problems to the informants.

Åfors glasswork was a company which started in 1876 and closed in 2012 due to the bad economical situation in the company. After its closure, the glasswork left behind contaminated soil with different concentrations of heavy metals such as, arsenic from arsenic trioxide, a chemical used to remove bubbles during the melting of glass, and lead oxide, a chemical used in the production of crystal glass. Crystal glass?s production occurred under 1921-1971, but emissions of lead into the air from Åfors glasswork continued until 2011, because of the artist Bertil Valliens? artglas was made in Åfors glasswork from 1970?s and onwards.The aim of this study was to estimate how much lead (Pb) and arsenic (As) that were released by Åfors Glasswork into the atmosphere during the operational period of the glasswork in comparison with how much of lead and arsenic were purchased for the company. Added to the assistance of the data from National Archives the variations in the activities of Åfors glasswork could be shown.

Entrepreneurship is a subject of growing attention, especially within public policy, media and research. Many studies have been done, but the subject of entrepreneurial exit has to a large extent been ignored. The aim of this study has been to investigate how entrepreneurs at an early stage in their career think about exit within a near future, and what factors influence their attitude towards exit. The study was conducted through a survey answered by 253 entrepreneurs active within business incubators in Sweden. Based on previous research on entrepreneurial intentions, a model of exit intentions was developed, and tested against several other factors.

This paper aims to examine how and to what extent, a transition of Sweden according to the principles of Omställning Sverige (Transition towns Sweden), have the potential to contribute to a society with increased happiness.The paper is based on a qualitative textual analysis of the key texts in the Swedish Transition towns movement, Omställning Sverige. In the first part of the study the most important transition principles of Omställning Sverige were identified. Four key principles emerged: An altered view of economics, a spiritual change, a stronger local community and increased awareness. These transition principles were then analyzed through the lens of the scientific fields position on happiness, followed by a summarizing conclusion.The altered view of economics which Omställning Sverige advocates, where sustainability and quality of life are priorities over economic growth, is even necessary to secure our basic physiological needs. Such an economy has also improved conditions for economic stability, high employment and higher efficiency in the sense of happiness promoted in relationship to how many natural resources are used.

Traditionally, it has been argued that companies are only responsible towards their shareholders, to maximize the profits. But lately it has changed into another way of responsibilty. It has become of great importance to demonstrate sustainable long-term values for stakeholders to identify with. This thesis aims to clarify the banks? definition of responsible investment and what criteria they assume when talking about such kind of investments.