The problem of finding targeted medicine is a central problem in chemotherapy. From this point of view the ubiquitin-proteasome system is a highly promising object in the pharmaceutical approach. Proteasome plays a critical role in cellular protein degradation, cell cycle and apoptosis regulation.Proteasome inhibitors are substances blocking the Actions of proteasome. Cancer cells are more sensitive to inhibition of the ubiquitin-proteasome system than normal cells. Therefore proteasome inhibitors have the potential to be successfully used in the cancer treatment.The study aimed to test various substances to identify possible proteasome inhibitors with the IncuCyteTM FLR image system and fluorometric microculture cytotoxicity assay.

The present study examines power relations, textual genre and attitudes to the matching process in the labor market in the employment office?s opinion articles in the period 2009?2014.     The power relations that emerge in the debate articles between employers, job seekers and private employment constitute the study's main question.The theoretical starting points are taken from Fairclough?s critical discourse analysis (1992, 2001, and 2010), where the discursive practice consists of the employment office?s production of opinion articles during a recession. The social practice consists of the laws and regulations that make its Actions to reduce unemployment in the society. The method is derived from Halliday?s (1994, 2002) systemic functional linguistics.

In this masters paper the change that Lidköping public library went through between 1952 and 1959 is described and analysed. The aim is to describe and analyse the reActions that arose at the time that the first professional librarian, Jörgen Elgström, acted to create a modern public library in the town. The issues that are handled are: How did the local politicians and the general public react to the process of change that was started by Jörgen Elgström? What were the consequences for the staff, the premises, lending, child and youth activities? The paper is concentrated around the period 1952-1959 because this is the time when Jörgen Elgström was working in Lidköping. Jörgen Elgström has a central role in the paper.

The background for this degree thesis is a need to replace the existing seal used to protect equipment containing secret or sensitive equipment used by Swedish Defence. The target design should satisfy both the need for tamper evidence and reduce Life Cycle Cost. In developing a new design for a seal, additional benefits such as improved logistics support and indication of attack methods such as heat and solvents have been considered.The lack of guiding principles for end users of seals became evident during the interviews. Major concerns for the future are education of users, information about Actions if a seal is broken and user liability.The design work was divided into several phases. A feasibility study was performed including investigation of theory of labels, materials and possible technologies.

Purpose: The study aims to analyze how companies can learn from past communications in critical situations and during corporate crisis, and see how they use this knowledge in the management of subsequent critical situations and corporate crisis. Furthermore, the media is analyzed to see how the newspaper industry chooses to reflect an organization and its Actions, and also to see if the pressure through articles in the newspapers has an impact on the extent of the situation.Method: A qualitative case study of Sweden?s largest food company, ICA Sverige AB, where knowledgeable people in media management within the company are interviewed using semi-structured interviews, with support of quantitative methods by a collection of articles from the news press.Theories: Concepts, theories and models in crisis management and communication has been applied to relevant data. These comprise Knowledge Management, a communication template in crisis management, The Situational Crisis Communication Theory (SCCT) and the model Content of crisis communication.Empiric: Based on the quantitative data consisting of articles from four Swedish news sources: Svenska Dagbladet, Dagens Nyheter, Aftonbladet and Expressen, a semi-structured interview guide was created and carried out with the person within ICA who possesses knowledge of the subject area.Conclusion: ICA has during the priod studied exhibited to have used the concept of Knowledge Management in the development of their routines regarding product recalls at product defects. The relationships between ICA and the media have shown improvements, which has resulted in ICA percieve the media coverage as balanced, true and fair..

Background: It is necessary for a company to hold some unique and irreplicable competitive advantage in order to be able to succeed in a market. In a market where public procurement is an important part the competitive advantages will be characterized by the fact that some of the participants on the market are public organizations and that their Actions as for procurement fall under the legislation LOU. The characteristics of competitive advantage also depend on and change with continuous changes on a market. Purpose: The purpose of this thesis is to study the competitive advantages that are presenton a current market characterized by public procurement and how these are created. The purposes is also to based on the trends on the market today study and predict the nature of the competitive advantage on the market in the future as well as the changes that we think will occur on the relevant market.

The main purpose of this thesis is to explore journalists? views of the role of journalism in the asylum processes. The potentially problematic phenomenon is growing, and its spread will affect the way publishing decisions are made in the future. The subject is new and foreign to many journalists, and little to no research has previously been done on the subject. Our study will therefore provide new insight in the field of journalism ethics.We have conducted a qualitative study based on interviews with eight Swedish journalists who in oneway or another have reported on threatened asylum seekers.

A common perception is that fungicide treatments increases yield, but that the nitrogen of the particular grain is diluted so that the overall removal of grain nitrogen from the field remains unchanged. The aim of this paper is to demonstrate that a healthy crop reduces the risk of nutrient loss from agricultural land. The results from genotype and plant protection trials often show constant nitrogen content in the grain, although the yield has been increased. Results from such experiments are therefore processed in order to confirm this and show that it is no statistically significant difference between the protein content (and also nitrogen content) in crops which have undergone fungicide treatment compared to crops which remained untreated. The trials processed have been carried out in the southernmost part of Sweden and are distinguished to concern winter wheat production.The explanation to the results is that a healthy crop is able to maintain the biological functions of the plant in a more efficient way than a crop damaged by a fungal infection.

Master thesis in business administration, School of business administration, Linnaeus University, accounting, 4FE03E, Spring 2011.Authors: Linda Åslund and Shirin Yousef.Supervisor: Professor Sven-Olof Yrjö CollinExaminer: Christopher von KochTitle: The Swedish code of good governance ? Who finds it useful? Background: Corporate governance has emerged to maintain the stockholders interests in corporations where the owners are separated from control in order to create confidence in the corporations. In 2005 the Swedish code of good governance emerged to prevent in part additional corporate scandals from happening and to make sure that the board is acting in the interest of the owners. The code is a complement to the Swedish Companies Act since it has a more strict demand in certain areas but it gives the companies a possibility to deviate by either complying or explaining their Actions.Purpose: The purpose with this thesis is to examine who finds the Swedish code of good governance useful.Method: The research method of this survey is quantitative where the purpose is to investigate deviations in the companies? corporate governance reports.

According to the immigration service forecasts Sweden faces large refugee influxes in the coming years. This means that educators in the kindergarten, preschool and school, will meat children from the war torn countries. In this study, the purpose is to find out the educators different conceptions of war-affected refugee children, because my theory is that their beliefs influence their Actions. I wanted to get answers to their beliefs about the difficulties or challengers that children and educators may be faced with. Furthermore, I wanted to know what educators envisioned about their own role?s importance to the war affected refugee children and their perceptions of the Swedish culture, environment, language and school.

Background: Motivation is a subject that is on everyone's lips in today's knowledge-intensive firms. What is motivation and what are we motivated by? We will, through three case studies, be grappling with the notion to clarify how managers and employees' perception of the concept is different, or possibly similar. Furthermore, the thesis examines whether the theory and practice of motivation are consistent with each other. Purpose: The purpose of our study is to seek understanding of what management within an organization believes are motivating their staff as well as how the staff perceive themselves be motivated by. We ask ourselves if organizations is up to date with the development of what motivates people.

This master thesis is written at the Royal Institute of Technology during the spring and summer of 2008.The assignment was to investigate what factors on a broadband market determine how well it performsin terms of how many people have access to broadband. These are the factors that determine whetheror not a country or market will be able to achieve a high broadband penetration. The purpose of thisthesis was to establish a better understanding for what a market should look like or how a strugglingone can be complemented in order to succeed.As a foundation for this investigation, a group of benchmark countries were chosen and evaluated. Inaddition to this, a group of, developing MENA2-countries were chosen and evaluated. Finally, interviewswere performed with some of Sweden?s leading internet service providers, the regulatory agency andinfrastructure company, Skanova.Among the benchmark countries were Sweden, France, Canada, South Korea and Japan.

The following paper is about degrading treatment in preschools and the essay discuss degrading treatment according to the Swedish school law, in preschools and the chosen focus for this study is three to four year old children. The aim is to see whether or not preschool children proceed with degrading treatment towards other children and if preschool teachers believe that children this young have the ability to do so. The questions for this study are: Can children proceed with degrading treatment towards each other? Which conflicts evolve through children?s interActions? Can children in pre-schools have a degrading behavior? To answer these questions participant observation at two preschools and interviews with four preschool teachers were chosen as method. The perspective of this paper is based on the view on children as actors, which is used to acknowledge and enhance the possibilities of letting the children?s own voices be heard.

The purpose of this essay was to analyze the management and steering of the social welfare service. The objective was specifically to examine how the leaders approach their position as managers of the social welfare service, and also how they approach their way of steering. The social welfare service acts under political decisions, but the management interpret and transform these decisions into Actions. The managers of the social welfare service are therefore important from a democratic perspective. The study was based on five qualitative interviews with two managers of the unity, two departmental managers and the head manager of the social welfare service.

The overall purpose of the essay is to analyse what Dietrich Bonhoeffer meant by Religionless Christianity. For this I have chosen to use the substantial idea analysis.I first came across the concept of freedom of religion to Christianity and Religionless Christians, in the book Dietrich Bonhoeffer: Tankar om en 1900-talsmartyr by Martin Lind in which he discusses what Bonhoeffer might discuss with Religionless Christians. This book is therefore the origin of the selection of literature I have chosen to use in the essay. Bonhoeffer writes several letters from prison about the movement he sees towards a new phase in human history, in which man can no longer be religious. However, Bonhoeffer uses the word religion in such a way that its content cannot be clearly determined.