Translationsnoggrannhet i läsningen mellan tRNA och mRNA
En analys av variationen i den maximala diskrimineringen d i initialselektion
Translation accuracyInitial selectionProtein synthesisRibosomeTranslationsnoggrannhetInitialselektionProteinsyntesRibosom
The purpose of this thesis is to analyze the variation in the maximal discrimination of the interaction between cognate and a non-cognate codon and anti-codon (also called the d-value). The variation was analyzed with a multiple regression model with the d-value as the dependent variable and with the codon position and the different mRNA and tRNA bases as independent variables. The result of the analysis not only confirmed earlier studies that the maximal accuracy was highest in the second codon position and lowest in the third codon position but we also found significant relationships and interaction effects.