Blodtrycksförändringar vid byte av vanligt kaffe mot koffeinfritt kaffe Hos friska, normotensiva individer
Sahlgrenska Academy at University of GothenburgDepartment of Internal Medicine and Clinical NutritionAbstractTitle: Changes in blood pressure by replacing regular coffee with decaffeinated coffee,in healthy, normotensive subjectsAuthor: Linnéa Adolfsson and Hillevi Pilgren SautterSupervisor: Lena HulthénExaminer: Anna WinkvistProgramme: Dietician study programme, 180/240 ECTSType of paper: Examination paper, 15 ECTSDate: April 12, 2012Background Hypertension is a risk factor for developing cardiovascular disease, which is themost common cause of premature death. Contributing factors to hypertension are genetics,lifestyle and nutrition. Earlier studies have shown that coffee may increase blood pressure.Objective To investigate the scientific basis whether replacing regular coffee with decaffeinatedcoffee would affect blood pressure in healthy, normotensive subjects.Search strategy Searches have been done in databases; PubMed and Scopus in February 2012.Keywords used were: ?coffee blood pressure?, ?coffee cardiovascular disease?, ? kaffeblodtryck?, ?kaffe hjärtkärlsjukdom?, ?coffee and decaffeinated coffee?, ?decaffeinated coffeeand blood pressure?, ?decaffeinated coffee and cardiovascular disease? and ?exchangedecaffeinated coffee?.Selection criteria Studies with healthy, normotesive subjects, >15 years old, BMI < 30, morethan one week of intervention, randomized controlled trails and human trials were included.Only trials using caffeine from coffee versus decaffeinated coffee and studies in English andSwedish were accepted. Exclusion criteria were other interventions such as weight loss, changesin diet, medications or stress tests.Data collection and analysis Studies were selected after inclusion and exclusion criteria. Theywere inspected according to SBU:s ?Granskningmall för randomiserad kontrollerad prövning?and quality of evidence was evaluated according to GRADE.Main results Three studies were included. Two of them showed a significant decrease in bloodpressure after changing type of coffee, systolic blodpressure 1,5-5,3 mm Hg and diastolicblodpressure 1,0 mm Hg. The third study showed no significant difference. The evidence isestimated to be moderate.Conclusion Replacing regular coffee with decaffeinated coffee gives a significant, but small, fallin blood pressure in healthy, normotensive subjects. The evidence is estimated to be moderate(+++). There is no greater gain in changing type of coffee for these individuals.