The dog is unique in the way that the adult weight can vary 100 folds between the different breeds. Despite this, most of the breeds reach adult size before two years of age. For the large-breed dogs this means a very rapid growth when some of them can have a weight gain of up to 150 times their birth weight. The most rapid growth occurs when the puppies are between three to six months old and that kind of rapid growth during such a short period of time makes these large-breed puppies very sensitive to deficits and excesses of energy, nutrients and minerals. Some examples can be excess of energy, excess or deficit of minerals such as calcium and phosphorus or deficits of protein. The rapid growth can also make the large-breed puppies predisposed to some diseases affecting the skeletal and joints.