In Uganda, small scale pig production plays a major role for households to earn a living and to secure their access to meat. Piglet mortality due to diar-rhoea-related dieseases is high. In an attempt to understand the underlying causes for this high mortality this study aims to investigate the role of trans-missible gastroenteritis virus (TGEV) and is a part of a larger project con-ducted at Makerere university in Uganda. A complicating factor in this investigation is the Porcine respiratory corona-virus (PRCV), a stabile mutant form of the TGE virus. The occurrence of this virus had shown to alter the impact of TGEV in e.g. Europe and North Amer-ica.

Uganda has the largest pig population in east Africa, and most of the animals are owned by smallholders. Infectious diseases among pigs have a devastating impact on the livelihood of these farmers, which are dependent on the proceeds from pig rearing. In a metagenomics study of the wild pig species bushpig (Potamochoerus larvatus), the Porcine viruses Torque teno sus virus (TTSuV) 1and 2 and Porcine parvovirus 4 (PPV4) were detected. TTSuV1 and 2 are ubiquitous in the world?s swine population, and PPV4 has been found in USA and China, but neither of them has been studied in Africa previously.

Immune stimulating complex (iscom) matrix is a formulation that is used as anadjuvant within research. The capability of the iscom matrix to elicit an immuneresponse when not present together with an antigen has not been extensivelyinvestigated. One way to evaluate the status of the immune system is to measure theamount of cytokines that usually are produced by various cell types during an immuneresponse. The aim of the present study was to evaluate the early immune responses inPorcine peripheral blood mononuclear cells (PBMC) after stimulation in vitro with theiscom matrix, AbISCO®-100. The immune response was evaluated by measuring themRNA expression for various cytokines, a chemokine receptor (CXCR4) andregulator of G-protein signaling (RGS16) in Porcine PBMC after stimulation withAbISCO®-100 or other inducers like a lipopolysaccharide (LPS) and a CpGoligodeoxynucleotide (ODN 2216) used as controls.

This study had two different aims. The main aim was to investigate the dynamics and impact of African swine fever (ASF) on a farm in Uganda during a recent outbreak through a case study. The second aim was to estimate the presence of two important differential diagnoses of ASF: Classical swine fever (CSF) and Porcine Reproduction and Respiratory syndrome (PRRS).The field and laboratory based case study of the farm level dynamics of ASF virus during a recent outbreak (October-December 2010) on a farm in the district of Mityana, Uganda, was conducted, using interviews, ELISA and RT-PCR. The financial impact on the farm was also estimated. The impact of the outbreak was profound.

Diabetes mellitus is an endocrine disorder affecting a range of different mammals, including dogs, cats, horses and humans. Worldwide, 347 million people have diabetes, and the disease is an increasing burden on the world?s poorest countries. The disease is characterised by chronic hyperglycaemia and afflicted individuals experience increased thirst, polyuria and weight loss, sometimes despite increased appetite. Diabetes mellitus is either insulin dependent or non-insulin dependent.

The occurrence and degree of osteochondrosis was studied in 64 pigs raised in conventional systems (45) or organically according to KRAVs principles (19). In this blind study the growth plates of distal radius and ulna were examined macroscopically and radiologically searching for pathological lesions. One significant difference was shown in this study. Conventionally raised pigs diagnosed with osteochondrosis had more severe lesions in the distal growth plate of radius and ulna than the corresponding group of pigs raised organically. No significant difference was shown between the groups when all pigs were included. .

Diabetes mellitus is a rising epidemic throughout the world and there is currently great interest in quantifying the beta-cell mass (BCM) in vivo non-invasively. In the present experiment, the feasibility of in vivo imaging of the glucagon-like peptide-1 receptor (GLP-1R) in beta-cells was examined, using the positron emission tomography (PET) tracer [68Ga]Ga-DO3A-VS-Cys40-exendin-4 as a marker, in native pancreatic beta-cells of a Porcine diabetic animal model and healthy controls. Eight Swedish high-health domestic pigs were randomly assigned to be either controls or made diabetic using streptozotocin (STZ). The experiment proceeded during eight weeks, starting with an acclimatisation period. Once the pigs had been socialised they underwent surgery for the insertion of a jugular vein catheter, allowing induction of diabetes with STZ, intravenous (i.v.) injections and stress-free blood sampling. Development of diabetes was confirmed by clinical examinations, blood glucose values and insulin-staining of pancreatic sections post mortem. The diabetic pigs were insulin treated and responded well.

Det finns många olika typer av bromerade flamskyddsmedel. De är alla stabila i miljön men graden av toxicitet och bioackumulering varierar. Att bromerade flamskyddsmedel är endokrinstörande är känt men min hypotes är att de även är neurotoxiska och att de kan orsaka neurologiska störningar hos människa. Människor exponeras för bromerade flamskyddsmedel via damm och föda. Barn och foster som är känsligare än vuxna kan även exponeras via modersmjölk respektive placenta. Barn har högre serumkoncentrationer av bromerade flamskyddsmedel än vuxna.

Rotavirus causes diarrhea in young mammals all over the world, including infant humans. The diarrhea leads to severe dehydration that can be fatal if left untreated. The dehydration can be treated with fluid therapy and the infection heals itself. Despite the relatively easy treatment half a million children under the age of five dies every year due to diarrhea caused by rotavirus. Rotavirus sorts into the family Reoviridae and is a double-stranded RNA virus with a segmented genome.

Rotavirus causes diarrhea in young mammals all over the world, including infant humans. The diarrhea leads to severe dehydration that can be fatal if left untreated. The dehydration can be treated with fluid therapy and the infection heals itself. Despite the relatively easy treatment half a million children under the age of five dies every year due to diarrhea caused by rotavirus. Rotavirus sorts into the family Reoviridae and is a double-stranded RNA virus with a segmented genome.

Proliferative enteropathy is a group of disease conditions in pigs where the disease may vary from subclinical to critical with bloody loose feces. The etiological agent is the obligate intracellular bacteria Lawsonia intracellularis. L. intracellularis infects enterocytes from jejunum to colon. The bacteria is taken into cells and start to replicate and cause a massive proliferation of immature enterocytes.

This study had two different aims. The main aim was to investigate the dynamics and impact of African swine fever (ASF) on a farm in Uganda during a recent outbreak through a case study. The second aim was to estimate the presence of two important differential diagnoses of ASF: Classical swine fever (CSF) and Porcine Reproduction and Respiratory syndrome (PRRS).The field and laboratory based case study of the farm level dynamics of ASF virus during a recent outbreak (October-December 2010) on a farm in the district of Mityana, Uganda, was conducted, using interviews, ELISA and RT-PCR. The financial impact on the farm was also estimated. The impact of the outbreak was profound.

Denna litteraturstudie syftar till att utreda om Treponema-arter är tänkbara etiologiska agens till öronnekros hos gris. Sjukdomen drabbar främst unga djur och då framförallt efter avvänjning. Symptomen yttrar sig som ytliga lesioner eller nekroser på ytterörat och det är vanligt att många djur drabbas vid samma tidpunkt. Sjukdomen anses vara ett djurvälfärdsproblem men är inte associerad med några produktionsnedgångar. Vid bakteriologiska undersökningar finner man framförallt spiroketer, kockoida och kockobacillära bakterier.

Uganda anses vara ett högriskland för utveckling av nya plötsligt uppdykande sjukdomar (emerging infectious diseases, EID). Grisproduktionen i Uganda har ökat drastiskt de senaste åren och en stor del av Ugandas grisar är frigående. De kan därför lätt komma i kontakt med vilda djur i deras närområde. Porcint circovirus 2 (PCV2) är ett ubikvitärt virus och etiologiskt agens för bland annat Porcine multisystemic wasting syndrome (PMWS). Förutom att infektera tamgrisar över hela världen så har PCV2 också visats kunna infektera vildsvin.

Uganda anses vara ett högriskland för utveckling av nya plötsligt uppdykande sjukdomar (emerging infectious diseases, EID). Grisproduktionen i Uganda har ökat drastiskt de senaste åren och en stor del av Ugandas grisar är frigående. De kan därför lätt komma i kontakt med vilda djur i deras närområde. Porcint circovirus 2 (PCV2) är ett ubikvitärt virus och etiologiskt agens för bland annat Porcine multisystemic wasting syndrome (PMWS). Förutom att infektera tamgrisar över hela världen så har PCV2 också visats kunna infektera vildsvin.