Möbius sequence is a rare condition where affected cranial nervesoften lead to speech deviations due to reduced oral motor functioning. Thisstudy aimed to survey speech deviations, compensatory strategies and selfperceptionof speech in seven people with Möbius sequence, and to linkthese to oral motor function and intelligibility. Additionally, the immediateeffects of smile surgery were investigated in one person. The abovementioneddomains were studied instrumentally, perceptually and throughstructured interviewing. All participants displayed reduced oral motorfunction.