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The role of mast cells and mast cell mediators in the development of atopic dermatitis in a mouse model
Atopic dermatitis (AD) is a complex, often lifelong allergic disease affecting around 10 % of both
dogs and humans. The hallmark symptom is severe pruritus, causing a lowered quality of life. Mast
cells (MCs) are known to play an important part of the immunopathogenesis, promoting a faulty T
helper cell type 2 (Th-2) response which follows by a production of specific immunoglobulin E
(IgE) antibodies towards environmental allergens (Ag). To further investigate the role of MCs and
its mediators in the progression of AD, a low-calcemic vitamin D3 analog (MC903) was used to
induce AD-like symptoms locally on the ears of two different knock-out (KO) mouse strains. The
first strain was Wsh-/- mice deficient in MCs.