Background: Diabetes mellitus is a chronic disease that manifests as an increased level of glucose in the blood. According to the World Health Organization (WHO), 347 million people have diabetes worldwide. In year 2004, 3.4 million people died from the consequences of high blood glucose. In the Swedish population the prevalence of diabetes is estimated to 3-4 %, out of which 85-90% are Type 2. Among senior citizens a prevalence of diabetes is seen in Sweden up to 14 - 15%.

Background:  Heart failure is a multidimensional phenomenon with high mortality. Heart failure is treated with angiotensin converting enzyme (ACE) - Inhibitors or angiotensin receptor blockers (ARBs) that counteract neurohormonal stimuli that occur in heart failure, as well as providing vessel dilatation, which reduces symptoms and the need for hospitalization and increases survival. Despite this, only about 50% of heart failure patients survive 6 years after diagnosis with drug therapy, and as heart failure is increasing globally, due to improved care and treatment and increasing life expectancy of the population, there is a great need for new drugs such as LCZ696 that acts by dual inhibition of the renin - angiotensin - aldosterone system and neprilysin inhibition.Objective: The aim of this literature study was to evaluate the efficacy of current treatment and possible future treatments on mortality and morbidity in heart failure patients.Results: The examined articles show that treatment with ACE Inhibitors in patients with symptomatic heart failure reduces the risk of total mortality by 16% over 3.5 years, reduces all-cause mortality or hospitalization due to heart failure with NNT (number needed to treat) = 10.4 over 3.5 years and increases median survival by 9.2 months over 12.1 years in patients with asymptomatic heart failure. Treatments with high-dose ACE Inhibitors reduce mortality and hospitalization because of cardiovascular causes and hospitalizations from any cause by NNT = 30 over 3 years. Beta-blockers reduce sudden death and total mortality and cardiac death or non - fatal myocardial infarction with NNT = 38 and NNT = 23, respectively, over 12 months.

Heart failure is a condition where the heart is incapable of providing adequate blood supply to different organs in the body. The underlying causes of heart failure is some kind of disorder in the heart function, and require careful diagnostics. The basic symptoms that arise from heart failure is difficulty in breathing, that aggravate when lying down, and fatigue. The patients? symptoms and impaired quality of life can be in different stages depending on the severity of the heart failure.

The problem of finding targeted medicine is a central problem in chemotherapy. From this point of view the ubiquitin-proteasome system is a highly promising object in the pharmaceutical approach. Proteasome plays a critical role in cellular protein degradation, cell cycle and apoptosis regulation.Proteasome Inhibitors are substances blocking the actions of proteasome. Cancer cells are more sensitive to inhibition of the ubiquitin-proteasome system than normal cells. Therefore proteasome Inhibitors have the potential to be successfully used in the cancer treatment.The study aimed to test various substances to identify possible proteasome Inhibitors with the IncuCyteTM FLR image system and fluorometric microculture cytotoxicity assay.

Background: Chemotherapy and radiation resistance are major causes of failure in cancer treatment. The response to treatment in cancer cells depends on several mechanisms and pathways such as Janus kinases-signal transducers and activators of transcription JAK/STAT pathway. STAT1 was the first described transcription factor in the STAT family. STAT1 is activated by stimulation of signaling proteins such as type II interferon (IFN- ?) and the activated STAT1 translocates from cytoplasm to nucleus.

There is a shortage of locally produced high quality protein concentrates in Europe andSweden. Local production would decrease the dependency on imported soybean and meet thedemand for organically grown feedstuff from ecological dairy farmers. Field bean (Viciafaba), peas (Pisum sativum) and sweet lupin (Lupinus angustifolius) are good alternatives tosoybean, but contain anti-nutritional substances (ANS) that could reduce their use as proteinconcentrates in dairy cow diets. The aim of this literature study was to review which ANSfield bean, peas and sweet lupin contain and whether they affect dairy cows negatively.Trypsin Inhibitors and Chymotrypsin Inhibitors (TI) were present in all three crops. TI couldbecome inactivated and degraded in the rumen, but due to the high passage speed of thedigesta, most TI left the rumen in an active state.

AbstractSyftet med studien var att utvärdera fluoxetins effekt på hetsätning och kräkning vid bulimia nervosadå ingen samtidigt psykoterapi ges. Även tid för behandlingseffekt, förändringar på andrasjukdomskarakteristika, förekomst av viktförändring och biverkningar undersöktes. Studiengenomfördes som en litteraturstudie. Sökningar efter litteratur skedde i Pubmed, Google, ELIN,Artikelsök, Cochrane, EMEA, SweMed+. Sökorden var; bulimia, bulimia nervosa, fluoxetine, prozac,psychotropic drugs, antidepressive agents, serotonin uptake Inhibitors, ätstörning, eating, disorder.Sammanfattningsvis hade fluoxetin 60 mg/dag en god effekt på att minska antalet hetsätningar ochkräkningar per vecka jämfört med placebo.

5-hydroxytryptamin (5-HT) is biochemically derived from Tryptophan. Kynurenic acid and quinolinic acid are also known metabolites of tryptophan. 5-HT is considered to play a role in depression and today selective serotonin reuptake Inhibitors (SSRIs) are used for treatment of depression. 5-HT may also play a role in pain perception. The aim of this study was to investigate whether a supplement of tryptophan may affect conditions such as depression and/or pain.

The purpose of this bachelor?s thesis is to examine how public librarians and people engaged in sports associations think of the possibility of collaboration between their organizations regarding children and youth and furthermore how they think this collaboration and collaboration in general would or should be practiced. This is done in the light of the increasing necessity of collaboration in today?s information society as well as the view that reading and sports could make a good match. Focus is placed on the libraries? perspective and also on the respondents? perceptions and thoughts.

An attempt was made to GFP-tag the effector proteins of AvrLm6 and AvrLm4-7 using the GFP-tagging gene knockout method (GGKO) developed by Saitoh et al. (2008) in order to determine whether or not they are secreted. Successful pETHG-(target)KO vectors were not generated. The protocol was examined for potential errors. Fatal errors were pinpointed to the ligation reaction and the transformation required to generate and propagate the desired vector pETGH-(target)KO.

Många människor i alla åldrar insjuknar varje år i cancer. I Sverige insjuknar mer än 7000 personer i åldrarna 20-54 år. I denna åldersgrupp är det många som har barn. Dessa barn kan ha blandade upplevelser och reaktioner på sin förälders sjukdom, vilket kan vara av vikt för sjuksköterskan att känna till, för att kunna ge dessa barn ett bra stöd. Syfte: Syftet var att beskriva barns upplevelser och coping-mekanismer av att leva med en förälder som har cancer.

The capability to know what knowledge there is and where it resides within an organization is becoming increasingly important in the new knowledge-based economy. This paper takes on a practise-based view of knowledge in order to decide on a course of action for how to successfully implement knowledge management within a knowledge-based company. By considering all knowledge as more or less contextual and socially constructed, knowledge is divided into three dimensions depending on the degree to which it is tacit, namely: information, knowledge and skills. The paper then discusses Inhibitors and enablers for transferring knowledge via these three dimensions respectively. The empirical findings are based upon a case study of Faveo. It is shown that Faveo, like most organizations, has til now focused on the collection of codified knowledge, i.e.

Vest, H. (2012).Möjligheter och hinder för samverkan inom offentlig sektor. Uppsats i pedagogik på kandidatnivå. Högskolan i Gävle, Akademin för utbildning och ekonomi.Denna undersökning syftar till att belysa upplevda möjligheter och hinder för samverkan, i arbetet med ungdomar rörande alkohol, narkotika, doping och tobak (ANDT). Studiesubjekten utgörs av 14 anställda på en kommun i södra Norrland.

On September 4, 2013, two men were shot in the suburb Biskopsgården in Gothenburg. This was the catalysts to a very problematic autumn in both Biskopsgården as in another suburb, Hisingsbacka. The local media reports of the events were very through, where the newspaper Göteborgs-Posten took a leading role. It?s these reports which form the basis, the so called material of our essay.

Matrix metalloproteinaser (MMPs) är en grupp proteolytiska enzymer som degraderar komponenter i vävnaders extracellulära matrix (ECM). Dessa proteiner spelar en viktig roll i många fysiologiska och patologiska processer. Enzymerna anses vara delaktiga vid olika typer av hjärtsjukdomar där de genom att utöva sin effekt påverkar sammansättningen hos ECM. Aktiviteten hos MMPs hämmas av TIMPs (tissue Inhibitors of metalloproteinases) som är enzymernas specifika inhibitorer. Balans mellan nedbrytning och uppbyggnad av ECM är nödvändigt för att bibehålla hjärtvävnadens normala struktur och funktion.