Every year many dogs in Sweden are bitten by the adder, a venomous snake (Vipera berus). Despite the fact that adder bites are so common in dogs there have been few investigations made that study the effects of treatment with Glucocorticoids, a drug that is commonly used. We have carried out a literature study concerning adder bites in dogs and a prospective study where case history, clinical signs and treatment have been recorded in dogs that were presented at two veterinary hospitals after a confirmed or suspected adder bite. Fifty three dogs were included in the study out of which 22 were treated with Glucocorticoids. In our study, the group of dogs treated with Glucocorticoids was compared with the group of dogs that did not receive glucocorticoid treatment by the owner or on arrival at the clinic.

The danger and vulnerability associated with a preterm birth seem to be closely correlated with a dysfunction of the fetal hypothalamic-pituitary-adrenal (HPA) axis, whose maturation in the foal is without a doubt as delicate as it is important. Not only is this endocrine cascade vital for the foal in order to cope with neonatal stress, it also appears to be fundamental for the final fetal intrauterine maturation, as well as for the onset of foaling. Equine gestation exhibits some rather unique features, indicating a somewhat different significance of the endocrine changes associated with HPA maturation, compared to many other species. This hormonal cascade is rapid and confined to a narrow time during late gestation in the horse, and the risk of the foal completely missing it therefore becomes prominent. Induced parturition in the mare may be operated through uterotonic agents, which occasionally bring about premature foals. Desirable seems the ability to initiate equine labour while simultaneously enhancing fetal HPA maturation, as in humans and ruminants through perinatal glucocorticoid administration. However, similar treatment in the horse has resulted in various, sometimes fatal, outcomes. In the light of the distinctive features of equine gestation, difficulties are encountered following such administration of Glucocorticoids and ACTH.

Platelets are important for the healing of damaged blood vessels since they have an importantpart to play in the coagulation process. At the same time, the blood must be kept fluid and notcoagulate at the wrong time. Therefore there are factors that effect the aggregation of plateletsin a positive or a negative way.Previous investigations have shown that platelets during stirring conditions produce reactiveoxygen species (ROS) that weaken the inhibiting effect of nitric oxides (NO) on platelets andthat the drug Dexamethasone (Dex) can reduce the ROS-production.The aim of this project was to investigate if Glucocorticoids, in this case Dexamethasone,could restore the inhibiting effect of NO on platelets and if there was any decrease in ROS-production.The result of the ROS-measurements showed a great variance and it was difficult to draw anyconclusions from them, but a clear decrease in ROS, as previous reported, was not shown. In the aggregation experiments the inhibiting effect of NO was observed through the drug S-nitroso-N-acetylpenicillamine (SNAP), a NO-donator.From the aggregation experiments, the result seemed to be that SNAP during longerincubation time lost its inhibiting effect, probably because the cells become desensitized.With superoxid dismutase (SOD), the effect of SNAP increased, both in the experiment withlonger and shorter incubation times. Dex seemed to reinforce the aggregation in relation toboth SOD and SNAP.

Dagens mjölkkor har kapacitet att producera stora mängder mjölk, men deras matsmältningssystem ser fortfarande likadant ut som när de producerade mjölk enbart till sin kalv. Detta innebär att de behöver foder med högt näringsvärde, eftersom de inte obegränsat kan öka foderkonsumtionen eller passagehastigheten om fodret har lågt näringsvärde. Vanligtvis är detta inget problem under stallperioden då korna ofta har fri tillgång på foder med väl anpassat näringsinnehåll. Under betesperioden däremot kan de högavkastande korna drabbas av näringsbrist eftersom de inte kan uppfylla sina behov enbart på betesgräs. Många faktorer inverkar på kornas konsumtion av bete, en del av dessa faktorer kan påverkas av lantbrukaren.