The effects of dexmedetomidine and Butorphanol sedation on skin reactivity during intradermal testing in healthy dogs were evaluated. The effects of dexmedetomidine and Butorphanol were compared to medetomidine, a sedative agent having scientific proof of not interfering with skin test reactivity, in a randomised, double blind, cross over study performed on 8 adult dogs. The dogs were sedated with medetomidine (Domitor vet.®, 0,01 ml kg-1) intravenously, or dexmedetomidine and Butorphanol intramuscularly (Dexdomitor vet.®, 0,01 ml kg-1; Dolorex vet., 0,01 ml kg-1) after which they received intradermal injections of positive control solutions (histamine 0,1 mg ml-1, 0,05 mg ml-1, 0,025 mg ml-1), a negative control solution (0,9 % NaCl) and allergen extract (Dermatophagoides farinae, Cladosporium and Artemisia vulgaris). After a wash out period the trial was repeated with a reversed sedation protocol.Skin reactivity (wheal size, induration and erythema) and quality of sedation (immobilization, response to stimuli and injections as well as over all working conditions) were evaluated. The combination of dexmedetomidine and Butorphanol provided reliable, good sedation and analgesia without adverse effects.

Today there are no analgesic drugs approved to be used in goats. Drugs approved for use in other species are consequently being used without knowing the pharmacokinetics of these drugs in goats. The purpose of this study was to investigate the pharmacokinetics of the opioid Butorphanol when given subcutaneously in goats. Subcutaneous administration might extend the half-life compared to intravenous or intramuscular administration. Eight clinically healthy, non-pregnant 6 months old female goats were used.

Hip dysplasia is a common, inherited malformation of the coxofemoral joint that eventually leads to osteoarthrosis. Several breeds of dogs are affected and the prevalence varies between different breeds. As part of the effort to reduce the prevalence of hip dysplasia and select dogs suitable for breeding, radiological screening is performed by at least 12 months of age. Before the radiological examination the dog has to be chemically restrained, sedated or anesthetized. The sedation protocol used differs between veterinary clinics. The impact of sedation method of the screening result for hip dysplasia has been studied.

The aim of the study was to investigate whether the sedation method had an effect on the screening result for hip dysplasia (HD). Another aspect considered was if the dog?s weight had an impact on the results. This study was a follow up on the results from an earlier study of sedation routines in Swedish dogs. The breeds included in this study were the same as in the earlier one; German shepherd, Bernese mountain dog, Boxer, Newfoundland, Rottweiler, Saint Bernard, Golden and Labrador Retriever.

Sammanfattning Idag genomförs många smärtsamma ingrepp på getter, så som kastrering och avhorning. Trots att det i svensk lagstiftning står att djur inte får utsättas för onödigt lidande finns det idag få smärtlindrande läkemedel som är godkända till get. Tidigare studier har visat att opioiden buprenorfin är olämpligt till getter. Syftet med den här studien var att genom att mäta olika fysiologiska parametrar undersöka om opioiden butorfanol kan vara eller inte vara ett lämpligt medel för getter. Läkemedlet är idag godkänt som smärtlindring till häst, hund och katt.