Alternativ splicing av pre-mRNA ger upphov till proteindiversitet. Histonmodifieringar kopplas till den alternativa splicingens reglering genom adaptorsystem som overfor den epigenetiska informationen direkt till splicingfaktorerna. De cis- agerande RNA- elementen pa exoner och introner med tillhorande trans- reglerande splicingfaktorer paverkas darfor direkt av specifika histonmodifieringar. En sammankopplande integrerad modell over en rad DNA- baserade processer foreslas. Denna komplexa modell ger en bild av interaktioner och paverkan mellan dessa delar.

Inom skogsnäringen sker idag en omfattande strukturomvandling. Från att ha varit en fragmenterad bransch med många små aktörer går nu företagen samman i internationella koncerner. Bland kooperativa företag sker även en utveckling mot alternativa former av kooperativa företag. Dessa bildas för att bättre möta omvärldens krav. Bland annat ägar-strukturen är under förändring genom att externa ägare bjuds in i olika utsträckning.

Lymphoma is a group of malignant tumour diseases developing in the secondary lymphatic system. These diseases can develop in all organs as lymphocytes are ubiquitously in the body. In connection to mucus membranes we find mucosa-associated lymphoid tissue, MALT, in which lymphoma can spontaneously but slowly develop, mostly at chronic inflammation or at autoimmune diseases. Today these diseases are incureable with the exception of some cases caused by Helicobacter pylori-infection. Antibiotic treatment of these cases can induce remissions.MALT-lymphomas have characteristic histological and molecular properties.

Rapporten ingår i ett FoU- projekt för Högskolan Dalarna, där målet är att ta fram en konstruktion utan ångspärr som ska klara dagens mått på lufttäthet och fuktkrav.Syftet med denna rapport är att utreda hur fukt påverkar en byggnad medmassivträstomme och olika isoleringsmaterial utan ångspärr. Mineralull och träfiberisolering jämförs mot varandra för att se hur dessa påverkarfuktbelastningen i en väggkonstruktion. Testobjektet är lokaliserat i Dalarna, inget fukttillskott har funnits inomhus i byggnaden.För att genomföra detta arbete har tre stycken olika metoder används. Ensimulering, verkliga uppmätta värden och en provtagning. Fuktsimuleringen genomfördes med hjälp av programmet WUFI, uppmätta värden i form av relativ fuktighet och temperatur har samlats in kontinuerligt under två års tid från väggkonstruktionen via mätsensorer.

An important task for Region Skåne is to allocate resources to the health care districts. From 1999 to 2002 Region Skåne used needs-based resource allocation as a model for allocating resources. In a needs-based resource allocation individuals with the same socioeconomic and demographic characteristics are assumed to have the same level of need and are therefore allocated the same amount of resources. During the period of needs-based resource allocation a matrix model was used as a method. In the matrix model individuals were divided into cells after each combination of the socioeconomic and demographic variables.

The system tungsten-oxygen has potential of being suitable for decorative coatings since ceramic coatings are often hard and wear resistant, and since modulations in oxygen content or incorporation of small ions could give bright colours. The aim of this report was to investigate the relationship between process parameters and  the properties of the films, with the wear resistance being of special interest.Samples with tungsten to oxygen ratios in the range of 100:0 to 25:75 at% were made using reactive sputter deposition, either with constant gas flow, or gas flow controlled by optical emission of the plasma. The hysteresis of the system, which means that a certain gas flow will cause different pressure and/or target voltage depending on in what way the flow is reached, makes it interesting to control the process where the system makes the steep change from metallic tungsten to ceramic tungsten oxide. This is difficult and thus requires precise control equipment.The samples were analysed using X-ray diffraction, X-ray photoelectron spectroscopy and an empirical wear test suitable for small components like cell phone cover for example, in order to characterize the structure, composition and wear resistance of the coatings. The results could be divided into three groups: (I) tungsten-like, with very low oxygen content; (II) mixed phase and (III) tungsten oxide like, with oxygen content close to 75 at%.

Today many buildings and it´s nearby surroundings are designed to achieve some kind of environmental goal.The issue concerning energy consumption is currently at focus and it is relevant that we start increase the share of renewable energy. Solar energy is an infinite resource and should therefore be considered when selecting an energy supplier. Uppsala University hospital is facing major restructuring when parts of the existing buildings will be refurbished and a large new building will be constructed. White Architects have developed a study concerning the new building and for some of the existing buildings on the hospital campus. Uppsala County requires tough energy measures and wants the new building to be classified as an eco-building in Whites following work. The classifications will involve high energy source requirements. This work has been conducted to see if solar power can be envisaged as a supplementary energy source for the University hospital and also to investigate the aesthetic impact of solar cells on the new building.

The present thesis closer examines what has come to be known as al-Qaida, partly from what al-Qaida is considered to be, partly from the consequences a certain picture of al-Qaida might give rise to. Between 1988-2001 most of this thesis sources refers to al-Qaida as a small, organized core group with some degree of cell structure. From 1991 to present days, many of the sources enlarge the picture of al-Qaida. From now on they start to view al-Qaida as either a network in itself or al-Qaida as a part of a larger islamistic network, not only as an organized core group with presumptive bases in Afghanistan. The most recent of theories regarding al-Qaida looks at al-Qaida as an ideology in itself (al-Qaedaism) or al-Qaida as a part of previously existing ideologies (Islamism, Neofundamentalism and Jihadism-Salafism).Al-Qaida is being seen - by scholars, journalists and terrorism experts - as an organization with a core group, a network in itself, part of a larger islamistic network and an ideology of its own or as a part of already existing ideologies.

It is important to know what is normal in the wound healing process in order to determine what happens when a wound does not heal as expected. If the amount of bacteria in the wound gets too large the body will not be able to defend itself and it becomes an infection. Colonization and infection are common elements in wound management and it is often the veterinary nurse role to deal with wounds in a proper manner. Antibiotics are drugs that either kill or inhibit the multiplication of bacteria or fungi, and have been in veterinary medicine for approximately 60 years. Very few new antibiotics are introduced and increased resistance is a major problem that requires everyone to take responsibility to reduce the use of it.

Abstract: The purpose of this study was to examine the process of overtraining syndrome as a part of development in sports and careers. It is based on theories about overtraining syndrome and athlete career transitions. The intention was to find patterns that illustrate critical factors in the athlete career for overtraining syndrome to occur, but also for preventing overtraining syndrome to emerge and for rehabilitation.The Informant was a 19 years old man who had completed his studies at a Swedish sports-?gymnasium?. Two semi structured interviews were made, the second as a following up interview.

Vid TCF-blekning av pappersmassa är väteperoxid en av huvudkemikalierna. I dagsläget är det svårt att styra blekstegen. Operatörerna måste ta hänsyn till produktionstakt, blekbarheten på massan varierar och fördröjning i trender. PO-bleksteget på Södra Cell Värö har en ungefärlig uppehållstid på 4 timmar och det är först efter så lång tid som man kan se hur en förändring verkligen slår igenom. Överblekning kostar väldigt mycket i kemikalieåtgång och det är därför efterfrågat ett sätt att kunna styra och optimera peroxidblekningssteget.

The increased frequency of reported Methicillin-resistant Staphylococcus pseudintermedius (MRSP) is of great concern to small animal healthcare due to limited options of antimicrobial therapy. The aim of this literature study is to investigate 1) characteristics and classification of S. pseudintermedius, 2) resistance mechanisms and emergence of MRSP, 3) risk factors for selection of MRSP, and 4) clonal distribution around the world. S. pseudintermedius is a skin and mucosal commensal in healthy dogs and cats, but can cause infections, including pyoderma. Beta-lactam antibiotics inhibit bacterial growth by binding to the penicillin binding protein (PBP), a vital enzyme in the synthesis of the bacterial cell wall.

The aim of this paper was to explain protein degradation in silage and protein quality and biogenic amines in silage and their effects on the health of the dairy cows. After harvest-ing, the plant proteases degrade the proteins in the plant. The protein degrades to different fractions with different digestibilites in the rumen. Fraction A contains non- protein nitro-gen which is peptides, free amino acids and amines. True protein is in the fraction B and is further divided into three subfractions depending on their solubility.

In some herds it has been observed that extremely short teats have become a problem; with a negative influence on the milking performance. The aim of this study was therefore to investigate to what degree the quality of the teats and the milk in cows with short teats is affected as compared with cows with normal teat length and furthermore if the milking performance could be improved by using a liner adapted to short teats. This study was divided in two parts. In the first part, it was examined if there were any differences between short teats and teats with normal length with reference to the milking performance, udder emptying, teat treatment, milk quality, and udder health. 11 pairs of cows were used and in each pair of cows one cow had teats shorter than 40 mm while the other cow had teats longer than 50 mm.

The escalating usage of pyrethroids has resulted in an increased awareness about resistance towards pyrethroids in insects. Pyrethroids inhibit voltage-sensitive sodium channels (VSSC) in nerve cell membranes and are composed of synthetic molecules based on pyrethrins present in pyrethrum extracts from Chrysanthemum species. VSSC are transmembrane proteins that are important for electric signalling over the membrane in insects. Mutations in the gene encoding the sodium channel have proved to be a common reason for resistance against pyrethroids. Pyrethroid resistance among pollen beetles is spread all over Sweden and also abroad and is increasing.