Feline Odontoclastic Resorptive Lesions (FORL) is a painful disease that affects feline teeth and that is increasing in prevalence. The ethiology is still rather unknown. However, research on the ultra structure of the feline tooth may help us understand why FORL is so prevalent in cats and not in other species. Since the ethiology is still unknown, there is yet no profylaxis. The pathogenesis is rather well known; the hard structure of affected teeth gradually undergo odontoclastic resorption and resorptive lesions are often partly replaced with bone- or cementum-like tissue.

It is common knowledge that our horses do occasionally hurt themselves and cause damage to their bodies. They also manage to do it in the most remarkable ways. The problem is not that they hurt themselves, because everybody does so from time to time. The problem is that they often experience difficulties with the healing of the wounds. The cause to that problem is the fact that they often lose a vast amount of tissue, the wound is more often than not extensively contaminated and the wound is often found a long time after the accident occurred.

Jönköping Small Animal Hospital is today the only clinic in Sweden to offer radiation therapy as a treatment of tumours. The body contains of billions of cells that all have to obey the regulations that are established. If a cell is exposed to a harmful substance, for example a chemical, it can be transformed into a tumourcell. Normally the body has a good defence but the tumourcell can survive and start to divide unrestrained. A tumour is starting to develop.

På Södra Innovations avdelning för forskning om fiber och massa har man uppmärksammat ett avvikande beteende på kraft-töjningskurvorna hos kräppat tissue-papper. Kurvan beter sig styvt där det i teorin borde vara töjbar och vice versa. Man vill därför veta vad det är i materialet som bidrar till att detta beteende uppstår och få en förklaring på vad som händer i materialet efter att det har belastats till brott. Detta vill man göra för att fortsatt kunna konkurrera med sin pappersmassa på marknaden och hjälpa sina kunder med deras utveckling av framtidens produkter.Projektet har gått ut på att utföra mätningar i dragprovare på kräppat tissue-papper, tillverkat i fabrik, och jämföra dessa mätningar med prover på okräppat papper, som tillverkas i laboratorium. Mätningarna har spelats in med ett ljusmikroskop för att lättare se vad som händer i materialet när det utsätts för last; vart den initierande sprickan uppstår och hur den tillväxer.Efter att ha analyserat mätdatat från dessa prover kunde man se att den största påverkande faktorn ligger i tillverkningsprocessen.

Tissue factor (TF), a 47 kDa glycoprotein, is the initiator of the extrinsic pathway of blood coagulation and consequently of the upmost importance when damage to blood vessel occurs. The source of TF in circulation has been investigated. However, the source of TF is still not clear. One theory is that platelets express and increases the expression of TF after stimulation and the aim of our report was to investigate whether platelets really are a source for TF in circulation.Using specific primers for TF mRNA, platelets in plasma from healthy volunteers and from patients suffering from cardiac infarction were analyzed by using real-time polymerase chain reaction (PCR). Gel electrophoresis was performed after amplification of TF mRNA to verify the results.The samples were negative for TF when using real-time PCR and the few positive all had cycle threshold (Ct) values above 35.

Kolorektal cancer (CRC) är en av de vanligaste cancersjukdomarna i världen med cirka 1 miljon nya detekterade fall per år. Special AT-rich sequence-binding protein1 (SATB1) är ett celltyp-specifikt kärnmatrix-associerat DNA-bindande protein, vilket utgörs av AT-rika DNA sekvenser. Det har tidigare demonstrerats att en annan medlem i SATB-familjen, SATB2, uttrycks på ett vävnadsspecifikt sätt i normal mukosa i nedre mag-tarmkanalen och i CRC. ?-catenin är en intracellulär mediator i Wnt/?-catenin signaleringsvägen, som spelar en viktig roll i kolorektal carcinogenes.

Actinomycosis is a rare, deep-seated infection of the jaw of cattle that include the progressive enlargement of bone structures. It is caused by Actinomyces bovis, a gram-positive rod found as a normal commensal of the alimentary canal in otherwise healthy animals. This paper shortly describes Actinomyces bovis and its ability to cause "lumpy jaw" or actinomycosis in cattle. It will describe its pathogenesis, diagnosis, treatment and some clinical presentations. The incidence of symptomatic actinomycosis infection is quite low in Sweden today.

The dog has often served as a model animal for humans in scientific studies. This is due to the fact that dogs are susceptible to a wide range of diseases which also affect humans. One example is cancer, a condition that affects dogs as well as owners. Neoplastic diseases account for 18-23 % of all deaths in dogs (Bonnet et al., 2005 and Jagielski et al., 2002). Mammary tumor, or tumor of the breast, is the most common tumor form in intact dogs and women (Im et al., 2013). Mammary tumors originate in the udder, and are classified according to their histological characteristics.

Several diseases increase the risk of thrombosis in dogs and cats, often with a fatal outcome. Currently there are no definite treatment guidelines for the use of thrombolytic and thromboprofylactic agents in veterinary medicine. None of these drugs are approved for dogs and cats in Sweden. Medicines aimed for humans have been used tentatively. This literature study is an investigation of what is currently known about the effects and safety of these pharmacological agents when used for dogs and cats.

Mammary gland neoplasia is one of the most common diseases in the bitch and the most common neoplastic disease. More than 13 % of the female dog population in Sweden suffers from mammary tumors during their lifetime. The disease can affect bitches in all ages but most often middle aged and older dogs. Some breeds such as Poodle and English Setter are predisposed for the disease. The aim of this study was to evaluate if it is possible to improve the post surgical healing process by using a pressure pad.

Picropodophyllin (PPP) is an analogue of the anti tumour lignan podophyllotoxin with the unique ability to selectively inhibit the receptor of Insulin like growth factor 1(IGF-1). IGF-1 is believed to play an important part in development of the endometrium facing implantation. With PPP treated mice, studies can be made to measure gene expression from tissue of both treated and untreated mice to compare the role of IGF-1 regarding ovulation, implantation and receptivity. The aim of this study was to analyze gene expression of some steroid hormone receptors and cytokines in ovaries from mice treated with PPP. In this study, seven mice were treated with PPP at different times and tissue was collected.

Chiari type I malformation is a condition in humans characterized by a small posterior cranial fossa, downward herniation of the cerebellar tonsils, foramen magnum overcrowding and disturbances of cerebrospinal fluid dynamics. Syringohydromyelia is often seen in patients with Chiari type I malformation. Syringohydromyelia is characterized by fluid-filled cavities in the spinal cord. This causes damage to the nervous tissue in the spinal cord. In recent years, a condition similar to Chiari type I malformation has been recognized in dogs. It has mostly been seen in Cavalier King Charles spaniels (CKCS). The condition seen in dogs is usually called occipital bone hypoplasia. The aim of the study was to examine whether there is a difference in the shape of the caudal fossa between CKCS, small bred dogs with a similar head shape and dogs with a normal head shape and if occipital bone hypoplasia is related to a head shape with a steep back of the head. Other aims of the study were to examine the crowding of nervous tissue in the foramen magnum in each breed group, the extent of syringohydromyelia and to what extent the malformation had caused neurological signs. Sculls from dogs on autopsy were divided in halves and the position of the cerebellum compared to the level of the foramen magnum was studied.

Bull terrier hereditary nephritis is caused by a mutation that leads to an inadequate synthesis of collagen type IV, which is an important component in the basement membranes. The inheritance of the mutation is autosomal dominant in bull terriers and progression to renal failure takes variable time, from several months to ten years. Proteinuria is the first clinical sign of the disease and the diagnosis is confirmed by transmission electron microscopy of renal tissue where typical ultrastructural changes in the glomerular basement membrane (GBM), thickening and multilaminar splitting are found. This study was performed in order to find out the occurrence of hereditary nephritis in bull terriers in Sweden through examination of urine samples and renal tissue and comparisons with how the disease is described in the literature. Urine samples from 76 Swedish bull terriers were collected and examined for proteinuria.

The equine hoof is often manipulated in purpose to achieve a better stride or to reduce the weight on damaged tissue. The living tissue in the hoof can?t store energy as glycogen and is therefore depending on a continuous supply of glucose for its energy production. The purpose of the study was to determine if wedging (i.e. elevating) the heel could influence the hooves glucose and lactate consumption/production. Five standardbred horses were trained to trot on a treadmill without getting physical or mentally tired.

Inclusion body disease (IBD) affecting boas and pythons is a serious and common disease. Boas can be clinically healthy carriers, which makes control of the disease difficult. The causative agent has not yet been confidently identified, and therefore there are no serodiagnostic tests available. Today, histopathologic examination of tissue biopsies is the recommended antemortem diagnostic method, but there are several disadvantages. The objective of this study was to compare the sensitivity of two diagnostic methods ? liver biopsies and blood smears, and to evaluate ultrasoundguided needle biopsy of the liver.