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1 Uppsatser om Thymidinkinase - Sida 1 av 1
Thymidinkinas 1 som tumörmarkör vid juvertumörer hos tik :
Determination of serum thymidine kinase 1 (TK-1) activity is used as a tumour
marker in both human and veterinary medicine. TK-1 is an intracellular enzyme
involved in a salvage pathway of DNA synthesis. The expression of TK-1 is cell
cycle dependent and the activity increases markedly after the G1 to S transition in
the cell cycle and then declines rapidly in G2. The pronounced proliferative
activity in tumour cells result in a higher TK-1 enzyme activity within the cell.
The fact that the increased TK-1 activity can be measured in serum makes TK-1 a
useful marker in diagnostics of neoplastic diseases and it provides information
regarding prognosis and treatment effectiveness. In human medicine a radioactive
based test is used to determine the TK-1 serum activity.